Incidental Mutation 'R0687:Tmem144'
ID261986
Institutional Source Beutler Lab
Gene Symbol Tmem144
Ensembl Gene ENSMUSG00000027956
Gene Nametransmembrane protein 144
Synonyms5730537D05Rik, 1110057I03Rik
MMRRC Submission 038872-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.082) question?
Stock #R0687 (G1)
Quality Score82
Status Not validated
Chromosome3
Chromosomal Location79812564-79852773 bp(-) (GRCm38)
Type of Mutationstart gained
DNA Base Change (assembly) G to A at 79839273 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000141832 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029568] [ENSMUST00000168038] [ENSMUST00000192341] [ENSMUST00000193410]
Predicted Effect probably benign
Transcript: ENSMUST00000029568
SMART Domains Protein: ENSMUSP00000029568
Gene: ENSMUSG00000027956

DomainStartEndE-ValueType
Pfam:DUF1632 11 266 3.7e-107 PFAM
Pfam:Sugar_transport 238 348 3.6e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000104273
Predicted Effect probably benign
Transcript: ENSMUST00000168038
SMART Domains Protein: ENSMUSP00000127837
Gene: ENSMUSG00000027956

DomainStartEndE-ValueType
Pfam:TMEM144 9 347 9.1e-142 PFAM
Pfam:Sugar_transport 238 348 4.9e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000192341
Predicted Effect probably benign
Transcript: ENSMUST00000193410
SMART Domains Protein: ENSMUSP00000141832
Gene: ENSMUSG00000027956

DomainStartEndE-ValueType
Pfam:DUF1632 11 137 7.3e-58 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194338
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.7%
  • 20x: 95.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 16 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931406P16Rik T G 7: 34,245,418 Q679P possibly damaging Het
Anxa10 T A 8: 62,092,572 D42V possibly damaging Het
B3gnt9 T A 8: 105,254,783 probably benign Het
Ccdc150 A T 1: 54,285,631 probably null Het
Fstl5 A G 3: 76,707,812 I727V possibly damaging Het
Nae1 C A 8: 104,513,244 R484L probably damaging Het
Nudt19 T A 7: 35,551,472 T281S probably benign Het
Osgin1 T A 8: 119,445,832 V455E probably damaging Het
Pcnx3 A T 19: 5,684,333 D655E probably damaging Het
Plch1 C T 3: 63,716,029 V617M probably damaging Het
Polk A T 13: 96,484,017 N579K probably damaging Het
Scube2 C A 7: 109,829,128 V513F possibly damaging Het
Skiv2l2 T C 13: 112,914,361 T227A probably damaging Het
Spen T C 4: 141,488,028 M498V unknown Het
Tm7sf3 T A 6: 146,621,890 N163I possibly damaging Het
Usp24 A T 4: 106,420,504 K2277I probably damaging Het
Other mutations in Tmem144
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00594:Tmem144 APN 3 79839167 missense probably benign 0.19
IGL01924:Tmem144 APN 3 79839194 missense probably damaging 1.00
IGL02080:Tmem144 APN 3 79822759 splice site probably benign
IGL02191:Tmem144 APN 3 79826852 missense possibly damaging 0.59
IGL02880:Tmem144 APN 3 79827622 missense probably benign 0.00
PIT4486001:Tmem144 UTSW 3 79826867 missense probably benign 0.00
R0080:Tmem144 UTSW 3 79839273 start gained probably benign
R0081:Tmem144 UTSW 3 79839273 start gained probably benign
R0164:Tmem144 UTSW 3 79839273 start gained probably benign
R0172:Tmem144 UTSW 3 79839273 start gained probably benign
R0173:Tmem144 UTSW 3 79839273 start gained probably benign
R0284:Tmem144 UTSW 3 79839273 start gained probably benign
R0285:Tmem144 UTSW 3 79839273 start gained probably benign
R0288:Tmem144 UTSW 3 79839273 start gained probably benign
R0445:Tmem144 UTSW 3 79825354 missense probably benign 0.01
R0549:Tmem144 UTSW 3 79822744 missense probably damaging 1.00
R1720:Tmem144 UTSW 3 79825299 missense probably damaging 1.00
R1748:Tmem144 UTSW 3 79825287 missense probably damaging 0.99
R1937:Tmem144 UTSW 3 79825304 missense probably damaging 0.99
R1955:Tmem144 UTSW 3 79826857 missense probably benign 0.13
R1978:Tmem144 UTSW 3 79825400 splice site probably null
R2025:Tmem144 UTSW 3 79827711 splice site probably null
R5241:Tmem144 UTSW 3 79814124 missense probably benign 0.13
R6674:Tmem144 UTSW 3 79839183 missense possibly damaging 0.91
R6862:Tmem144 UTSW 3 79832099 missense probably benign
R7536:Tmem144 UTSW 3 79827657 missense probably benign
R8033:Tmem144 UTSW 3 79825317 missense probably benign
RF012:Tmem144 UTSW 3 79822654 missense probably damaging 1.00
Predicted Primers
Posted On2015-02-04