Incidental Mutation 'R0687:Tmem144'
| ID |
261986 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tmem144
|
| Ensembl Gene |
ENSMUSG00000027956 |
| Gene Name |
transmembrane protein 144 |
| Synonyms |
5730537D05Rik, 1110057I03Rik |
| MMRRC Submission |
038872-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.070)
|
| Stock # |
R0687 (G1)
|
| Quality Score |
82 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
79719871-79760080 bp(-) (GRCm39) |
| Type of Mutation |
start gained |
| DNA Base Change (assembly) |
G to A
at 79746580 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000141832
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000029568]
[ENSMUST00000168038]
[ENSMUST00000192341]
[ENSMUST00000193410]
|
| AlphaFold |
Q8VEH0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000029568
|
| SMART Domains |
Protein: ENSMUSP00000029568
Gene: ENSMUSG00000027956
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF1632
|
11 |
266 |
3.7e-107 |
PFAM |
|
Pfam:Sugar_transport
|
238 |
348 |
3.6e-12 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000104273
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168038
|
| SMART Domains |
Protein: ENSMUSP00000127837
Gene: ENSMUSG00000027956
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TMEM144
|
9 |
347 |
9.1e-142 |
PFAM |
|
Pfam:Sugar_transport
|
238 |
348 |
4.9e-13 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000192341
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193410
|
| SMART Domains |
Protein: ENSMUSP00000141832
Gene: ENSMUSG00000027956
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF1632
|
11 |
137 |
7.3e-58 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000194338
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.9%
- 10x: 97.7%
- 20x: 95.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 16 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Anxa10 |
T |
A |
8: 62,545,606 (GRCm39) |
D42V |
possibly damaging |
Het |
| B3gnt9 |
T |
A |
8: 105,981,415 (GRCm39) |
|
probably benign |
Het |
| Ccdc150 |
A |
T |
1: 54,324,790 (GRCm39) |
|
probably null |
Het |
| Fstl5 |
A |
G |
3: 76,615,119 (GRCm39) |
I727V |
possibly damaging |
Het |
| Garre1 |
T |
G |
7: 33,944,843 (GRCm39) |
Q679P |
possibly damaging |
Het |
| Mtrex |
T |
C |
13: 113,050,895 (GRCm39) |
T227A |
probably damaging |
Het |
| Nae1 |
C |
A |
8: 105,239,876 (GRCm39) |
R484L |
probably damaging |
Het |
| Nudt19 |
T |
A |
7: 35,250,897 (GRCm39) |
T281S |
probably benign |
Het |
| Osgin1 |
T |
A |
8: 120,172,571 (GRCm39) |
V455E |
probably damaging |
Het |
| Pcnx3 |
A |
T |
19: 5,734,361 (GRCm39) |
D655E |
probably damaging |
Het |
| Plch1 |
C |
T |
3: 63,623,450 (GRCm39) |
V617M |
probably damaging |
Het |
| Polk |
A |
T |
13: 96,620,525 (GRCm39) |
N579K |
probably damaging |
Het |
| Scube2 |
C |
A |
7: 109,428,335 (GRCm39) |
V513F |
possibly damaging |
Het |
| Spen |
T |
C |
4: 141,215,339 (GRCm39) |
M498V |
unknown |
Het |
| Tm7sf3 |
T |
A |
6: 146,523,388 (GRCm39) |
N163I |
possibly damaging |
Het |
| Usp24 |
A |
T |
4: 106,277,701 (GRCm39) |
K2277I |
probably damaging |
Het |
|
| Other mutations in Tmem144 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00594:Tmem144
|
APN |
3 |
79,746,474 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL01924:Tmem144
|
APN |
3 |
79,746,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02080:Tmem144
|
APN |
3 |
79,730,066 (GRCm39) |
splice site |
probably benign |
|
|
IGL02191:Tmem144
|
APN |
3 |
79,734,159 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL02880:Tmem144
|
APN |
3 |
79,734,929 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4486001:Tmem144
|
UTSW |
3 |
79,734,174 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0080:Tmem144
|
UTSW |
3 |
79,746,580 (GRCm39) |
start gained |
probably benign |
|
|
R0081:Tmem144
|
UTSW |
3 |
79,746,580 (GRCm39) |
start gained |
probably benign |
|
|
R0164:Tmem144
|
UTSW |
3 |
79,746,580 (GRCm39) |
start gained |
probably benign |
|
|
R0172:Tmem144
|
UTSW |
3 |
79,746,580 (GRCm39) |
start gained |
probably benign |
|
|
R0173:Tmem144
|
UTSW |
3 |
79,746,580 (GRCm39) |
start gained |
probably benign |
|
|
R0284:Tmem144
|
UTSW |
3 |
79,746,580 (GRCm39) |
start gained |
probably benign |
|
|
R0285:Tmem144
|
UTSW |
3 |
79,746,580 (GRCm39) |
start gained |
probably benign |
|
|
R0288:Tmem144
|
UTSW |
3 |
79,746,580 (GRCm39) |
start gained |
probably benign |
|
|
R0445:Tmem144
|
UTSW |
3 |
79,732,661 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0549:Tmem144
|
UTSW |
3 |
79,730,051 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1720:Tmem144
|
UTSW |
3 |
79,732,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1748:Tmem144
|
UTSW |
3 |
79,732,594 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1937:Tmem144
|
UTSW |
3 |
79,732,611 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1955:Tmem144
|
UTSW |
3 |
79,734,164 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1978:Tmem144
|
UTSW |
3 |
79,732,707 (GRCm39) |
splice site |
probably null |
|
|
R2025:Tmem144
|
UTSW |
3 |
79,735,018 (GRCm39) |
splice site |
probably null |
|
|
R5241:Tmem144
|
UTSW |
3 |
79,721,431 (GRCm39) |
missense |
probably benign |
0.13 |
|
R6674:Tmem144
|
UTSW |
3 |
79,746,490 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6862:Tmem144
|
UTSW |
3 |
79,739,406 (GRCm39) |
missense |
probably benign |
|
|
R7536:Tmem144
|
UTSW |
3 |
79,734,964 (GRCm39) |
missense |
probably benign |
|
|
R8033:Tmem144
|
UTSW |
3 |
79,732,624 (GRCm39) |
missense |
probably benign |
|
|
R8746:Tmem144
|
UTSW |
3 |
79,732,655 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8748:Tmem144
|
UTSW |
3 |
79,743,539 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9223:Tmem144
|
UTSW |
3 |
79,734,964 (GRCm39) |
missense |
probably benign |
|
|
R9641:Tmem144
|
UTSW |
3 |
79,734,200 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9658:Tmem144
|
UTSW |
3 |
79,729,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF012:Tmem144
|
UTSW |
3 |
79,729,961 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
|
| Posted On |
2015-02-04 |
Incidental Mutation