Incidental Mutation 'R0670:Treml2'
ID |
261988 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Treml2
|
Ensembl Gene |
ENSMUSG00000071068 |
Gene Name |
triggering receptor expressed on myeloid cells-like 2 |
Synonyms |
LOC328833 |
MMRRC Submission |
038855-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.050)
|
Stock # |
R0670 (G1)
|
Quality Score |
93 |
Status
|
Not validated
|
Chromosome |
17 |
Chromosomal Location |
48606526-48619561 bp(+) (GRCm39) |
Type of Mutation |
splice site |
DNA Base Change (assembly) |
A to G
at 48614864 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000128215
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170941]
|
AlphaFold |
Q2LA85 |
Predicted Effect |
probably null
Transcript: ENSMUST00000170941
|
SMART Domains |
Protein: ENSMUSP00000128215 Gene: ENSMUSG00000071068
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
IG
|
31 |
129 |
3.13e-5 |
SMART |
low complexity region
|
181 |
199 |
N/A |
INTRINSIC |
transmembrane domain
|
268 |
290 |
N/A |
INTRINSIC |
|
Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.8%
- 10x: 97.6%
- 20x: 95.7%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 35 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
a |
A |
T |
2: 154,887,678 (GRCm39) |
D46V |
probably damaging |
Het |
Abraxas2 |
A |
T |
7: 132,470,760 (GRCm39) |
|
probably null |
Het |
Afap1l2 |
G |
A |
19: 56,904,235 (GRCm39) |
T684I |
probably damaging |
Het |
Ahcyl1 |
A |
T |
3: 107,578,481 (GRCm39) |
V205E |
probably damaging |
Het |
Ap4e1 |
T |
A |
2: 126,853,784 (GRCm39) |
|
probably null |
Het |
Brms1 |
C |
A |
19: 5,095,999 (GRCm39) |
N24K |
probably damaging |
Het |
Celf3 |
ACAGCAGCAGCAGCAGCAGCAGCA |
ACAGCAGCAGCAGCAGCAGCA |
3: 94,395,537 (GRCm39) |
|
probably benign |
Het |
Col25a1 |
A |
G |
3: 130,180,544 (GRCm39) |
K130E |
possibly damaging |
Het |
Crisp1 |
A |
C |
17: 40,616,001 (GRCm39) |
Y125* |
probably null |
Het |
Dnhd1 |
A |
T |
7: 105,345,671 (GRCm39) |
D2272V |
possibly damaging |
Het |
Elmod1 |
A |
G |
9: 53,820,106 (GRCm39) |
V294A |
probably damaging |
Het |
Gmfg |
T |
A |
7: 28,140,953 (GRCm39) |
I33K |
probably damaging |
Het |
Gsk3b |
G |
T |
16: 37,964,678 (GRCm39) |
D49Y |
probably damaging |
Het |
H2-T5 |
G |
C |
17: 36,478,990 (GRCm39) |
F86L |
possibly damaging |
Het |
Harbi1 |
C |
T |
2: 91,542,880 (GRCm39) |
R114W |
probably damaging |
Het |
Hspbp1 |
A |
G |
7: 4,680,735 (GRCm39) |
V247A |
probably damaging |
Het |
Kif17 |
A |
T |
4: 137,989,810 (GRCm39) |
|
probably benign |
Het |
Klhl6 |
T |
A |
16: 19,768,309 (GRCm39) |
H412L |
possibly damaging |
Het |
Muc1 |
A |
G |
3: 89,137,839 (GRCm39) |
D227G |
probably benign |
Het |
Nat8f5 |
A |
T |
6: 85,794,957 (GRCm39) |
M1K |
probably null |
Het |
Neb |
A |
G |
2: 52,146,136 (GRCm39) |
V2947A |
possibly damaging |
Het |
Nfrkb |
A |
T |
9: 31,331,469 (GRCm39) |
Q1295L |
probably benign |
Het |
Otop1 |
T |
C |
5: 38,445,292 (GRCm39) |
V150A |
possibly damaging |
Het |
Pcdhb2 |
A |
T |
18: 37,429,701 (GRCm39) |
D558V |
probably damaging |
Het |
Pdilt |
T |
C |
7: 119,099,651 (GRCm39) |
K206E |
probably benign |
Het |
Pkn2 |
A |
T |
3: 142,545,104 (GRCm39) |
I23K |
probably damaging |
Het |
Plec |
A |
T |
15: 76,090,160 (GRCm39) |
L60Q |
probably damaging |
Het |
Ranbp2 |
C |
A |
10: 58,316,520 (GRCm39) |
D2413E |
probably benign |
Het |
Socs1 |
A |
G |
16: 10,602,126 (GRCm39) |
Y204H |
probably damaging |
Het |
Stk39 |
T |
C |
2: 68,196,526 (GRCm39) |
D301G |
possibly damaging |
Het |
Tlr5 |
T |
A |
1: 182,801,454 (GRCm39) |
W253R |
probably damaging |
Het |
Ttn |
A |
G |
2: 76,579,448 (GRCm39) |
L22069P |
probably damaging |
Het |
Vps13c |
G |
T |
9: 67,833,139 (GRCm39) |
S1614I |
probably benign |
Het |
Vrk2 |
C |
T |
11: 26,436,959 (GRCm39) |
|
probably null |
Het |
Xrn1 |
A |
G |
9: 95,873,109 (GRCm39) |
Y655C |
probably damaging |
Het |
|
Other mutations in Treml2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01767:Treml2
|
APN |
17 |
48,609,838 (GRCm39) |
missense |
probably benign |
|
IGL02797:Treml2
|
APN |
17 |
48,609,739 (GRCm39) |
missense |
possibly damaging |
0.73 |
Cottonwood
|
UTSW |
17 |
48,609,775 (GRCm39) |
missense |
possibly damaging |
0.89 |
poplar
|
UTSW |
17 |
48,609,762 (GRCm39) |
nonsense |
probably null |
|
R0105:Treml2
|
UTSW |
17 |
48,609,856 (GRCm39) |
missense |
probably damaging |
0.99 |
R0105:Treml2
|
UTSW |
17 |
48,609,856 (GRCm39) |
missense |
probably damaging |
0.99 |
R1538:Treml2
|
UTSW |
17 |
48,609,786 (GRCm39) |
missense |
possibly damaging |
0.77 |
R1796:Treml2
|
UTSW |
17 |
48,616,530 (GRCm39) |
makesense |
probably null |
|
R4396:Treml2
|
UTSW |
17 |
48,615,142 (GRCm39) |
missense |
probably benign |
0.00 |
R4679:Treml2
|
UTSW |
17 |
48,615,203 (GRCm39) |
missense |
probably benign |
0.36 |
R4687:Treml2
|
UTSW |
17 |
48,616,425 (GRCm39) |
splice site |
probably null |
|
R4801:Treml2
|
UTSW |
17 |
48,616,187 (GRCm39) |
missense |
probably benign |
0.18 |
R4802:Treml2
|
UTSW |
17 |
48,616,187 (GRCm39) |
missense |
probably benign |
0.18 |
R5314:Treml2
|
UTSW |
17 |
48,607,601 (GRCm39) |
missense |
probably damaging |
0.99 |
R6791:Treml2
|
UTSW |
17 |
48,616,247 (GRCm39) |
missense |
probably benign |
0.24 |
R6818:Treml2
|
UTSW |
17 |
48,609,925 (GRCm39) |
missense |
probably damaging |
1.00 |
R6958:Treml2
|
UTSW |
17 |
48,615,180 (GRCm39) |
missense |
probably damaging |
1.00 |
R7250:Treml2
|
UTSW |
17 |
48,616,155 (GRCm39) |
missense |
probably benign |
0.05 |
R7535:Treml2
|
UTSW |
17 |
48,609,847 (GRCm39) |
missense |
probably damaging |
1.00 |
R7850:Treml2
|
UTSW |
17 |
48,615,168 (GRCm39) |
missense |
probably benign |
0.01 |
R8049:Treml2
|
UTSW |
17 |
48,609,762 (GRCm39) |
nonsense |
probably null |
|
R8998:Treml2
|
UTSW |
17 |
48,609,775 (GRCm39) |
missense |
possibly damaging |
0.89 |
R9012:Treml2
|
UTSW |
17 |
48,615,090 (GRCm39) |
missense |
possibly damaging |
0.86 |
R9208:Treml2
|
UTSW |
17 |
48,614,922 (GRCm39) |
nonsense |
probably null |
|
|
Predicted Primers |
|
Posted On |
2015-02-04 |