Incidental Mutation 'R0724:Pira13'
ID 262010
Institutional Source Beutler Lab
Gene Symbol Pira13
Ensembl Gene ENSMUSG00000074419
Gene Name paired-Ig-like receptor A13
Synonyms Gm15448, ENSMUSG00000074419
MMRRC Submission 038906-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.049) question?
Stock # R0724 (G1)
Quality Score 37
Status Validated
Chromosome 7
Chromosomal Location 3816781-3825687 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 3816872 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 564 (N564S)
Ref Sequence ENSEMBL: ENSMUSP00000104260 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094911] [ENSMUST00000108619] [ENSMUST00000108620] [ENSMUST00000153846] [ENSMUST00000189095]
AlphaFold F6PZL4
Predicted Effect probably benign
Transcript: ENSMUST00000094911
SMART Domains Protein: ENSMUSP00000092515
Gene: ENSMUSG00000074419

DomainStartEndE-ValueType
IG_like 40 105 3.26e0 SMART
IG 129 315 1.37e-1 SMART
IG_like 237 302 2.2e-1 SMART
IG 328 415 6.31e-1 SMART
IG 430 519 8.01e-3 SMART
Predicted Effect unknown
Transcript: ENSMUST00000108619
AA Change: N665S
SMART Domains Protein: ENSMUSP00000104259
Gene: ENSMUSG00000074419
AA Change: N665S

DomainStartEndE-ValueType
IG_like 40 105 3.26e0 SMART
IG 129 315 1.37e-1 SMART
IG_like 237 302 2.2e-1 SMART
IG 328 415 6.31e-1 SMART
IG_like 429 517 6.02e0 SMART
IG 529 618 8.01e-3 SMART
low complexity region 637 646 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000108620
AA Change: N564S

PolyPhen 2 Score 0.831 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000104260
Gene: ENSMUSG00000074419
AA Change: N564S

DomainStartEndE-ValueType
IG_like 40 105 3.26e0 SMART
IG 129 315 1.37e-1 SMART
IG_like 237 302 2.2e-1 SMART
IG 328 415 6.31e-1 SMART
IG 430 519 8.01e-3 SMART
low complexity region 538 547 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000153846
AA Change: N682S
SMART Domains Protein: ENSMUSP00000121707
Gene: ENSMUSG00000074419
AA Change: N682S

DomainStartEndE-ValueType
IG 7 96 8.01e-3 SMART
low complexity region 132 141 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000189095
SMART Domains Protein: ENSMUSP00000140974
Gene: ENSMUSG00000074419

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
IG_like 40 105 1.3e-2 SMART
IG 129 315 5.7e-4 SMART
IG_like 237 302 9e-4 SMART
IG 328 415 2.6e-3 SMART
IG_like 429 517 2.4e-2 SMART
IG 529 618 3.3e-5 SMART
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.9%
  • 10x: 97.5%
  • 20x: 95.2%
Validation Efficiency 100% (62/62)
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700018F24Rik A G 5: 145,044,763 (GRCm38) E136G probably benign Het
Adgre4 T A 17: 55,852,281 (GRCm38) S655R probably benign Het
Ak7 T A 12: 105,710,254 (GRCm38) V71E probably benign Het
Ank2 C T 3: 126,962,337 (GRCm38) R1077H probably damaging Het
Anxa3 A G 5: 96,828,748 (GRCm38) T198A possibly damaging Het
Atp1a1 A T 3: 101,592,439 (GRCm38) I109N possibly damaging Het
Camta1 A G 4: 151,077,892 (GRCm38) I119T probably damaging Het
Carm1 A G 9: 21,587,374 (GRCm38) Y504C probably damaging Het
Casp1 C T 9: 5,303,077 (GRCm38) P177L probably benign Het
Ccdc122 C A 14: 77,092,077 (GRCm38) probably benign Het
Ces1a A G 8: 93,039,513 (GRCm38) S158P probably damaging Het
Ces3a T A 8: 105,050,195 (GRCm38) D103E possibly damaging Het
Clstn1 A C 4: 149,643,624 (GRCm38) D583A possibly damaging Het
Corin A G 5: 72,332,795 (GRCm38) probably benign Het
Cryba1 T C 11: 77,719,457 (GRCm38) D144G probably damaging Het
Cwf19l2 G T 9: 3,421,377 (GRCm38) probably null Het
Dis3l T C 9: 64,307,126 (GRCm38) T1027A possibly damaging Het
Dop1b A G 16: 93,762,325 (GRCm38) E653G probably benign Het
Dst A G 1: 34,188,677 (GRCm38) I1459V probably benign Het
Dyrk3 T C 1: 131,130,140 (GRCm38) T64A probably benign Het
Emp2 C T 16: 10,284,615 (GRCm38) C111Y probably benign Het
Enam A G 5: 88,501,994 (GRCm38) Y454C probably damaging Het
Fbn1 A T 2: 125,352,064 (GRCm38) C1328S probably benign Het
Gata3 T C 2: 9,874,575 (GRCm38) T197A probably benign Het
Gm1043 A G 5: 37,187,229 (GRCm38) T212A probably damaging Het
H2-Eb1 T C 17: 34,315,032 (GRCm38) probably benign Het
Hand1 T C 11: 57,831,680 (GRCm38) H36R probably damaging Het
Hmgcs2 C A 3: 98,297,001 (GRCm38) Y239* probably null Het
Hoxc12 A G 15: 102,937,055 (GRCm38) Y68C probably damaging Het
Inpp5a A G 7: 139,516,663 (GRCm38) I143V probably benign Het
Klhdc2 C A 12: 69,297,048 (GRCm38) F18L probably benign Het
Kpnb1 T C 11: 97,178,304 (GRCm38) Y251C probably damaging Het
Lrch4 A T 5: 137,637,308 (GRCm38) N315I probably damaging Het
Map3k10 A C 7: 27,668,355 (GRCm38) V286G probably damaging Het
Myo7b G A 18: 32,005,549 (GRCm38) probably benign Het
Nlrp2 G T 7: 5,319,222 (GRCm38) L809I probably damaging Het
Oacyl T C 18: 65,737,825 (GRCm38) probably benign Het
Or4q3 A G 14: 50,345,917 (GRCm38) V175A possibly damaging Het
Paxbp1 T A 16: 91,036,536 (GRCm38) D270V probably damaging Het
Pdia3 G A 2: 121,432,377 (GRCm38) G275S probably damaging Het
Plcb3 G A 19: 6,963,392 (GRCm38) R359C probably damaging Het
Plcxd3 G A 15: 4,516,868 (GRCm38) S118N probably damaging Het
Ptpn14 T C 1: 189,850,947 (GRCm38) S664P possibly damaging Het
Sirt1 T C 10: 63,323,973 (GRCm38) I443V possibly damaging Het
Slc7a8 G A 14: 54,735,186 (GRCm38) probably benign Het
Smim14 A G 5: 65,453,339 (GRCm38) probably benign Het
Sost C T 11: 101,966,918 (GRCm38) C19Y probably benign Het
Tcaf1 G T 6: 42,675,367 (GRCm38) A727E probably damaging Het
Thoc1 T C 18: 9,963,829 (GRCm38) L144P probably damaging Het
Tmem132b A T 5: 125,783,421 (GRCm38) T577S possibly damaging Het
Tnfrsf21 C T 17: 43,038,213 (GRCm38) H239Y probably benign Het
Tshr T C 12: 91,538,286 (GRCm38) F666S probably damaging Het
Wdr1 A G 5: 38,540,862 (GRCm38) V192A possibly damaging Het
Zfp697 T C 3: 98,428,166 (GRCm38) W416R probably damaging Het
Other mutations in Pira13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00434:Pira13 APN 7 3,823,089 (GRCm38) missense probably damaging 1.00
IGL01675:Pira13 APN 7 3,822,608 (GRCm38) splice site probably benign
IGL02040:Pira13 APN 7 3,821,517 (GRCm38) splice site probably benign
IGL02547:Pira13 APN 7 3,821,661 (GRCm38) missense probably damaging 0.98
IGL02749:Pira13 APN 7 3,822,625 (GRCm38) missense probably damaging 1.00
IGL02822:Pira13 APN 7 3,816,918 (GRCm38) missense possibly damaging 0.50
IGL02883:Pira13 APN 7 3,822,180 (GRCm38) missense possibly damaging 0.95
IGL03140:Pira13 APN 7 3,823,248 (GRCm38) missense probably benign 0.00
IGL03185:Pira13 APN 7 3,823,230 (GRCm38) missense probably damaging 1.00
IGL03212:Pira13 APN 7 3,823,133 (GRCm38) missense probably benign 0.00
R0347:Pira13 UTSW 7 3,822,874 (GRCm38) missense probably damaging 1.00
R0652:Pira13 UTSW 7 3,822,763 (GRCm38) missense probably benign 0.02
R0668:Pira13 UTSW 7 3,822,700 (GRCm38) missense probably damaging 0.99
R0735:Pira13 UTSW 7 3,821,782 (GRCm38) missense possibly damaging 0.79
R1074:Pira13 UTSW 7 3,823,070 (GRCm38) missense probably damaging 1.00
R1339:Pira13 UTSW 7 3,822,156 (GRCm38) missense probably damaging 1.00
R1541:Pira13 UTSW 7 3,816,989 (GRCm38) missense probably damaging 1.00
R1570:Pira13 UTSW 7 3,823,061 (GRCm38) missense probably benign 0.45
R1880:Pira13 UTSW 7 3,824,951 (GRCm38) critical splice donor site probably null
R1892:Pira13 UTSW 7 3,824,574 (GRCm38) missense probably benign 0.15
R1909:Pira13 UTSW 7 3,822,919 (GRCm38) missense probably benign 0.31
R2881:Pira13 UTSW 7 3,825,641 (GRCm38) start codon destroyed probably null 0.98
R2967:Pira13 UTSW 7 3,822,687 (GRCm38) missense probably damaging 1.00
R2983:Pira13 UTSW 7 3,821,575 (GRCm38) missense probably damaging 1.00
R4213:Pira13 UTSW 7 3,821,554 (GRCm38) missense probably damaging 1.00
R4319:Pira13 UTSW 7 3,822,755 (GRCm38) missense possibly damaging 0.46
R4320:Pira13 UTSW 7 3,822,755 (GRCm38) missense possibly damaging 0.46
R4321:Pira13 UTSW 7 3,822,755 (GRCm38) missense possibly damaging 0.46
R4322:Pira13 UTSW 7 3,822,755 (GRCm38) missense possibly damaging 0.46
R4323:Pira13 UTSW 7 3,822,755 (GRCm38) missense possibly damaging 0.46
R4536:Pira13 UTSW 7 3,822,252 (GRCm38) missense probably benign 0.00
R4597:Pira13 UTSW 7 3,822,155 (GRCm38) missense possibly damaging 0.81
R4713:Pira13 UTSW 7 3,822,681 (GRCm38) nonsense probably null
R4725:Pira13 UTSW 7 3,821,548 (GRCm38) missense probably benign
R4934:Pira13 UTSW 7 3,822,677 (GRCm38) missense probably damaging 1.00
R4971:Pira13 UTSW 7 3,822,806 (GRCm38) missense probably benign 0.00
R5138:Pira13 UTSW 7 3,824,557 (GRCm38) nonsense probably null
R5805:Pira13 UTSW 7 3,822,623 (GRCm38) missense probably benign 0.15
R5824:Pira13 UTSW 7 3,824,754 (GRCm38) missense probably damaging 1.00
R5841:Pira13 UTSW 7 3,822,899 (GRCm38) nonsense probably null
R6027:Pira13 UTSW 7 3,824,639 (GRCm38) missense possibly damaging 0.94
R6214:Pira13 UTSW 7 3,821,718 (GRCm38) missense probably damaging 0.99
R6329:Pira13 UTSW 7 3,822,851 (GRCm38) missense probably damaging 1.00
R6429:Pira13 UTSW 7 3,822,346 (GRCm38) missense possibly damaging 0.63
R6650:Pira13 UTSW 7 3,816,899 (GRCm38) missense possibly damaging 0.83
R6681:Pira13 UTSW 7 3,822,252 (GRCm38) missense probably benign 0.00
R6961:Pira13 UTSW 7 3,825,125 (GRCm38) missense probably damaging 1.00
R6989:Pira13 UTSW 7 3,822,164 (GRCm38) missense possibly damaging 0.95
R7025:Pira13 UTSW 7 3,821,262 (GRCm38) nonsense probably null
R7071:Pira13 UTSW 7 3,821,668 (GRCm38) missense unknown
R7194:Pira13 UTSW 7 3,824,793 (GRCm38) missense
R7215:Pira13 UTSW 7 3,822,311 (GRCm38) missense unknown
R7580:Pira13 UTSW 7 3,824,612 (GRCm38) missense unknown
R7776:Pira13 UTSW 7 3,823,247 (GRCm38) missense unknown
R7863:Pira13 UTSW 7 3,824,802 (GRCm38) critical splice acceptor site probably null
R7909:Pira13 UTSW 7 3,821,709 (GRCm38) missense unknown
R8131:Pira13 UTSW 7 3,822,162 (GRCm38) nonsense probably null
R8178:Pira13 UTSW 7 3,821,261 (GRCm38) missense unknown
R8188:Pira13 UTSW 7 3,823,127 (GRCm38) missense unknown
R8220:Pira13 UTSW 7 3,822,904 (GRCm38) missense unknown
R8226:Pira13 UTSW 7 3,825,110 (GRCm38) missense
R8441:Pira13 UTSW 7 3,823,302 (GRCm38) nonsense probably null
R8739:Pira13 UTSW 7 3,825,189 (GRCm38) missense
R8785:Pira13 UTSW 7 3,816,929 (GRCm38) missense unknown
R8912:Pira13 UTSW 7 3,822,819 (GRCm38) missense unknown
R8941:Pira13 UTSW 7 3,822,381 (GRCm38) missense probably damaging 1.00
R8990:Pira13 UTSW 7 3,821,274 (GRCm38) missense unknown
R9049:Pira13 UTSW 7 3,816,891 (GRCm38) missense unknown
R9090:Pira13 UTSW 7 3,816,998 (GRCm38) missense unknown
R9134:Pira13 UTSW 7 3,822,183 (GRCm38) missense
R9136:Pira13 UTSW 7 3,823,286 (GRCm38) missense
R9244:Pira13 UTSW 7 3,822,227 (GRCm38) missense unknown
R9271:Pira13 UTSW 7 3,816,998 (GRCm38) missense unknown
R9328:Pira13 UTSW 7 3,824,581 (GRCm38) missense unknown
Predicted Primers PCR Primer
(F):5'- GGTTCAGGAAACAAAGGCTCCCAG -3'
(R):5'- TGGAACTCAGAAGAAACACTACGGC -3'

Sequencing Primer
(F):5'- TGAGGAAGCACCTCATTATGAC -3'
(R):5'- AGAGTAGAACCTTGTCATCTCCG -3'
Posted On 2015-02-04