Incidental Mutation 'R0104:Tas2r120'
ID262058
Institutional Source Beutler Lab
Gene Symbol Tas2r120
Ensembl Gene ENSMUSG00000059382
Gene Nametaste receptor, type 2, member 120
Synonymsmt2r47, mGR20, Tas2r20, T2R20
MMRRC Submission 038390-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.049) question?
Stock #R0104 (G1)
Quality Score93
Status Not validated
Chromosome6
Chromosomal Location132656953-132657844 bp(+) (GRCm38)
Type of Mutationsplice site (2 bp from exon)
DNA Base Change (assembly) T to A at 132657846 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000071626 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071707]
Predicted Effect probably null
Transcript: ENSMUST00000071707
SMART Domains Protein: ENSMUSP00000071626
Gene: ENSMUSG00000059382

DomainStartEndE-ValueType
Pfam:TAS2R 1 294 2.4e-77 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 96.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] TAS2R46 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Sep 2009]
Allele List at MGI
Other mutations in this stock
Total: 17 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Dnah5 A T 15: 28,453,353 E4423D possibly damaging Het
Fsip2 A T 2: 82,978,973 T1879S possibly damaging Het
Gm136 G T 4: 34,746,593 H139Q possibly damaging Het
Ifrd2 T A 9: 107,587,917 L10H probably damaging Het
Itpr3 C A 17: 27,095,992 H704Q probably benign Het
Kcng1 A G 2: 168,269,046 I66T probably damaging Het
Kcnv2 T C 19: 27,323,219 Y157H probably damaging Het
Leng8 A G 7: 4,143,808 D443G probably damaging Het
Mlst8 T C 17: 24,476,117 N264S possibly damaging Het
Pcdhb8 A G 18: 37,355,665 E132G probably benign Het
Pmpcb C G 5: 21,746,038 S266* probably null Het
Prmt7 T C 8: 106,237,350 I292T probably damaging Het
Rif1 T C 2: 52,110,092 L1186S possibly damaging Het
Sox30 A C 11: 45,981,314 E332A possibly damaging Het
Taf2 T C 15: 55,038,338 D820G probably benign Het
Zfp655 T C 5: 145,244,015 S228P probably damaging Het
Zfyve9 C A 4: 108,718,163 D574Y probably damaging Het
Other mutations in Tas2r120
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00694:Tas2r120 APN 6 132657275 missense probably benign 0.01
IGL01725:Tas2r120 APN 6 132657089 nonsense probably null
IGL01860:Tas2r120 APN 6 132657264 missense probably damaging 0.99
IGL01891:Tas2r120 APN 6 132657844 makesense probably null
PIT4519001:Tas2r120 UTSW 6 132657334 missense probably benign
R0108:Tas2r120 UTSW 6 132657846 splice site probably null
R0123:Tas2r120 UTSW 6 132657589 nonsense probably null
R0225:Tas2r120 UTSW 6 132657589 nonsense probably null
R1812:Tas2r120 UTSW 6 132657601 missense probably benign 0.02
R2254:Tas2r120 UTSW 6 132657609 missense probably benign
R3110:Tas2r120 UTSW 6 132657768 missense probably damaging 1.00
R3112:Tas2r120 UTSW 6 132657768 missense probably damaging 1.00
R4829:Tas2r120 UTSW 6 132657368 missense probably benign 0.03
R5248:Tas2r120 UTSW 6 132657147 missense probably damaging 0.97
R5372:Tas2r120 UTSW 6 132657483 missense possibly damaging 0.54
R6379:Tas2r120 UTSW 6 132657810 missense probably benign 0.00
R7015:Tas2r120 UTSW 6 132657165 missense possibly damaging 0.48
R7615:Tas2r120 UTSW 6 132657810 missense probably benign 0.00
R8004:Tas2r120 UTSW 6 132657427 missense possibly damaging 0.82
R8796:Tas2r120 UTSW 6 132657118 missense probably damaging 1.00
Z1176:Tas2r120 UTSW 6 132657185 missense probably benign 0.01
Predicted Primers
Posted On2015-02-04