Incidental Mutation 'T0975:Or10ak9'
ID 262137
Institutional Source Beutler Lab
Gene Symbol Or10ak9
Ensembl Gene ENSMUSG00000073769
Gene Name olfactory receptor family 10 subfamily AK member 9
Synonyms MOR259-3P, GA_x6K02T2QD9B-18670866-18669913, Olfr1331
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # T0975 (G3) of strain 714
Quality Score 148
Status Not validated
Chromosome 4
Chromosomal Location 118725980-118726933 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 118726500 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Methionine at position 174 (R174M)
Ref Sequence ENSEMBL: ENSMUSP00000101967 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094831] [ENSMUST00000106360] [ENSMUST00000216589]
AlphaFold K7N684
Predicted Effect probably benign
Transcript: ENSMUST00000094831
AA Change: R174M

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000092426
Gene: ENSMUSG00000073769
AA Change: R174M

DomainStartEndE-ValueType
Pfam:7tm_4 32 308 2.1e-53 PFAM
Pfam:7tm_1 42 291 3.9e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106360
AA Change: R174M

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000101967
Gene: ENSMUSG00000073769
AA Change: R174M

DomainStartEndE-ValueType
Pfam:7tm_1 41 290 1.2e-28 PFAM
Pfam:7tm_4 139 283 2.8e-45 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216589
AA Change: R173M

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.7%
  • 10x: 97.0%
  • 20x: 93.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930556J24Rik TAA TAAA 11: 3,887,945 (GRCm39) probably null Het
4930556J24Rik C T 11: 3,926,324 (GRCm39) A27T unknown Het
Ago3 C T 4: 126,298,056 (GRCm39) V155I probably benign Het
Ago3 G A 4: 126,298,103 (GRCm39) A139V probably benign Het
Ago3 C T 4: 126,298,098 (GRCm39) A141T probably benign Het
Ahdc1 ACCTCCT ACCTCCTCCT 4: 132,790,065 (GRCm39) probably benign Het
Azin2 A G 4: 128,839,927 (GRCm39) Y222H probably benign Het
Bpifb5 C A 2: 154,071,384 (GRCm39) probably null Het
Castor1 G C 11: 4,170,445 (GRCm39) G147A probably benign Het
Ccdc157 C T 11: 4,096,246 (GRCm39) A455T probably damaging Het
Ccng1 A C 11: 40,644,871 (GRCm39) S9A probably benign Het
Cfh T C 1: 140,082,336 (GRCm39) T164A probably benign Het
Cherp TTGGACCTGGACCTGGACCTGGACCTGGA TTGGACCTGGACCTGGACCTGGA 8: 73,215,878 (GRCm39) probably benign Het
Chrng T C 1: 87,138,348 (GRCm39) S380P probably benign Het
Clspn ACGGCGGCGGCGGCG ACGGCGGCGGCGGCGGCGGCG 4: 126,460,230 (GRCm39) probably benign Het
Ctrc T TA 4: 141,572,507 (GRCm39) probably null Het
Cxxc1 C T 18: 74,353,992 (GRCm39) R593C probably damaging Het
Dlgap1 T C 17: 70,823,950 (GRCm39) S312P possibly damaging Het
Dnah10 A G 5: 124,840,130 (GRCm39) S1255G probably benign Het
Dpep1 A T 8: 123,927,727 (GRCm39) S388C probably damaging Het
Emid1 T C 11: 5,094,386 (GRCm39) T42A probably damaging Het
Emid1 A C 11: 5,078,884 (GRCm39) L353V probably benign Het
Epn3 A G 11: 94,382,733 (GRCm39) probably null Het
Fam124b T C 1: 80,190,843 (GRCm39) E180G probably benign Het
Fam135b T G 15: 71,335,734 (GRCm39) T487P probably damaging Het
Gja4 G C 4: 127,206,024 (GRCm39) H246Q probably benign Het
Gm9972 GA GAA 11: 42,927,597 (GRCm39) probably null Het
Hmmr G C 11: 40,614,243 (GRCm39) N148K probably damaging Het
Homez C T 14: 55,094,796 (GRCm39) R304K possibly damaging Het
Ifngr1 G A 10: 19,485,221 (GRCm39) V407M probably damaging Het
Inpp5j G T 11: 3,452,527 (GRCm39) T241N possibly damaging Het
Kif12 GGGGC GGGGCCTCCACCCGGCGGGC 4: 63,089,660 (GRCm39) probably benign Het
Kremen1 C T 11: 5,145,105 (GRCm39) A424T probably benign Het
Mat2b G A 11: 40,570,918 (GRCm39) T302I probably benign Het
Mtmr3 C T 11: 4,438,441 (GRCm39) R671K probably benign Het
Nacad GCAGGGTCAGGGTC GCAGGGTCAGGGTCAGGGTC 11: 6,549,750 (GRCm39) probably benign Het
Nacad T C 11: 6,551,622 (GRCm39) N523S probably benign Het
Nacad A G 11: 6,551,632 (GRCm39) C520R probably benign Het
Nefh G A 11: 4,890,151 (GRCm39) P823S probably benign Het
Nfrkb G C 9: 31,308,379 (GRCm39) A230P probably benign Het
Nlrp4a A G 7: 26,149,062 (GRCm39) E223G probably damaging Het
Notch3 T A 17: 32,365,391 (GRCm39) Y1107F probably damaging Het
Or13g1 A T 7: 85,955,492 (GRCm39) Y276* probably null Het
Or6c35 A G 10: 129,169,314 (GRCm39) D188G probably benign Het
Osm A G 11: 4,189,588 (GRCm39) D124G probably benign Het
Plekhm2 TTCCTCCTCCT TTCCTCCT 4: 141,359,292 (GRCm39) probably benign Het
Pomgnt1 C T 4: 115,994,624 (GRCm39) probably benign Het
Spen A G 4: 141,201,664 (GRCm39) V2321A probably benign Het
Sytl1 TCTGC TC 4: 132,984,305 (GRCm39) probably benign Het
Tcn2 G C 11: 3,873,487 (GRCm39) F286L possibly damaging Het
Tg T C 15: 66,560,712 (GRCm39) S10P probably benign Het
Tmprss7 C T 16: 45,501,096 (GRCm39) R235Q probably benign Het
Tns3 G A 11: 8,499,100 (GRCm39) probably benign Het
Tns3 G T 11: 8,401,146 (GRCm39) L1051M probably benign Het
Tns3 T G 11: 8,429,518 (GRCm39) E806A probably benign Het
Toe1 T C 4: 116,663,290 (GRCm39) I62M probably benign Het
Txnrd2 A G 16: 18,294,315 (GRCm39) H436R probably damaging Het
Ubr4 C T 4: 139,179,092 (GRCm39) P2001S probably damaging Het
Vmn2r23 T A 6: 123,690,120 (GRCm39) M332K probably benign Het
Zbtb8a GG GGATG 4: 129,253,812 (GRCm39) probably benign Het
Zbtb8a T C 4: 129,254,005 (GRCm39) H163R probably benign Het
Zfyve21 A G 12: 111,794,067 (GRCm39) D206G probably damaging Het
Zkscan4 AGAGGAG AGAG 13: 21,663,370 (GRCm39) probably benign Het
Zmym1 A C 4: 126,943,466 (GRCm39) H307Q probably benign Het
Zmym1 C T 4: 126,941,740 (GRCm39) D785N probably benign Het
Zmym1 C T 4: 126,942,043 (GRCm39) V684I probably benign Het
Zpld2 GTG GTGCTG 4: 133,929,940 (GRCm39) probably benign Het
Other mutations in Or10ak9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00090:Or10ak9 APN 4 118,726,484 (GRCm39) missense probably damaging 1.00
IGL01314:Or10ak9 APN 4 118,726,328 (GRCm39) missense probably benign 0.26
IGL02025:Or10ak9 APN 4 118,726,362 (GRCm39) missense probably damaging 1.00
IGL02458:Or10ak9 APN 4 118,726,497 (GRCm39) missense possibly damaging 0.83
IGL02793:Or10ak9 APN 4 118,726,794 (GRCm39) missense probably damaging 1.00
IGL02827:Or10ak9 APN 4 118,726,157 (GRCm39) missense probably damaging 0.99
IGL02863:Or10ak9 APN 4 118,726,083 (GRCm39) missense possibly damaging 0.52
IGL03125:Or10ak9 APN 4 118,726,118 (GRCm39) missense possibly damaging 0.95
R0078:Or10ak9 UTSW 4 118,726,424 (GRCm39) missense probably benign
R0152:Or10ak9 UTSW 4 118,726,083 (GRCm39) missense possibly damaging 0.89
R0299:Or10ak9 UTSW 4 118,726,613 (GRCm39) missense probably benign 0.00
R3881:Or10ak9 UTSW 4 118,726,550 (GRCm39) missense probably benign 0.00
R3928:Or10ak9 UTSW 4 118,726,179 (GRCm39) missense probably damaging 1.00
R3929:Or10ak9 UTSW 4 118,726,179 (GRCm39) missense probably damaging 1.00
R5288:Or10ak9 UTSW 4 118,726,772 (GRCm39) missense probably damaging 1.00
R5552:Or10ak9 UTSW 4 118,726,665 (GRCm39) missense probably damaging 1.00
R5672:Or10ak9 UTSW 4 118,726,379 (GRCm39) missense possibly damaging 0.83
R5773:Or10ak9 UTSW 4 118,726,718 (GRCm39) missense probably damaging 0.97
R6117:Or10ak9 UTSW 4 118,726,341 (GRCm39) missense probably benign 0.39
R6910:Or10ak9 UTSW 4 118,726,335 (GRCm39) missense probably damaging 1.00
R6911:Or10ak9 UTSW 4 118,726,335 (GRCm39) missense probably damaging 1.00
R6912:Or10ak9 UTSW 4 118,726,335 (GRCm39) missense probably damaging 1.00
R7164:Or10ak9 UTSW 4 118,726,922 (GRCm39) missense probably benign 0.30
R7446:Or10ak9 UTSW 4 118,726,019 (GRCm39) missense possibly damaging 0.83
R9747:Or10ak9 UTSW 4 118,726,217 (GRCm39) missense probably damaging 1.00
Predicted Primers
Posted On 2015-02-04