Incidental Mutation 'T0975:Ctrc'
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ID262161
Institutional Source Beutler Lab
Gene Symbol Ctrc
Ensembl Gene ENSMUSG00000062478
Gene Namechymotrypsin C (caldecrin)
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.106) question?
Stock #T0975 (G3) of strain 714
Quality Score153
Status Not validated
Chromosome4
Chromosomal Location141814962-141846359 bp(-) (GRCm38)
Type of Mutationframe shift
DNA Base Change (assembly) T to TA at 141845196 bp
ZygosityHeterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000037059] [ENSMUST00000105781]
Predicted Effect probably null
Transcript: ENSMUST00000037059
SMART Domains Protein: ENSMUSP00000039879
Gene: ENSMUSG00000062478

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
Tryp_SPc 29 261 4.88e-87 SMART
Predicted Effect probably null
Transcript: ENSMUST00000105781
SMART Domains Protein: ENSMUSP00000101407
Gene: ENSMUSG00000062478

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
Tryp_SPc 29 229 9.66e-59 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128368
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136064
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153282
Predicted Effect probably null
Transcript: ENSMUST00000176781
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.7%
  • 10x: 97.0%
  • 20x: 93.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930556J24Rik TAA TAAA 11: 3,937,945 probably null Het
4930556J24Rik C T 11: 3,976,324 A27T unknown Het
Ago3 C T 4: 126,404,263 V155I probably benign Het
Ago3 C T 4: 126,404,305 A141T probably benign Het
Ago3 G A 4: 126,404,310 A139V probably benign Het
Ahdc1 ACCTCCT ACCTCCTCCT 4: 133,062,754 probably benign Het
Azin2 A G 4: 128,946,134 Y222H probably benign Het
Bpifb5 C A 2: 154,229,464 probably null Het
Ccdc157 C T 11: 4,146,246 A455T probably damaging Het
Ccng1 A C 11: 40,754,044 S9A probably benign Het
Cfh T C 1: 140,154,598 T164A probably benign Het
Cherp TTGGACCTGGACCTGGACCTGGACCTGGA TTGGACCTGGACCTGGACCTGGA 8: 72,462,034 probably benign Het
Chrng T C 1: 87,210,626 S380P probably benign Het
Clspn ACGGCGGCGGCGGCG ACGGCGGCGGCGGCGGCGGCG 4: 126,566,437 probably benign Het
Cxxc1 C T 18: 74,220,921 R593C probably damaging Het
Dlgap1 T C 17: 70,516,955 S312P possibly damaging Het
Dnah10 A G 5: 124,763,066 S1255G probably benign Het
Dpep1 A T 8: 123,200,988 S388C probably damaging Het
Emid1 A C 11: 5,128,884 L353V probably benign Het
Emid1 T C 11: 5,144,386 T42A probably damaging Het
Epn3 A G 11: 94,491,907 probably null Het
Fam124b T C 1: 80,213,126 E180G probably benign Het
Fam135b T G 15: 71,463,885 T487P probably damaging Het
Gatsl3 G C 11: 4,220,445 G147A probably benign Het
Gja4 G C 4: 127,312,231 H246Q probably benign Het
Gm7534 GTG GTGCTG 4: 134,202,629 probably benign Het
Gm9972 GA GAA 11: 43,036,770 probably null Het
Hmmr G C 11: 40,723,416 N148K probably damaging Het
Homez C T 14: 54,857,339 R304K possibly damaging Het
Ifngr1 G A 10: 19,609,473 V407M probably damaging Het
Inpp5j G T 11: 3,502,527 T241N possibly damaging Het
Kif12 GGGGC GGGGCCTCCACCCGGCGGGC 4: 63,171,423 probably benign Het
Kremen1 C T 11: 5,195,105 A424T probably benign Het
Mat2b G A 11: 40,680,091 T302I probably benign Het
Mtmr3 C T 11: 4,488,441 R671K probably benign Het
Nacad GCAGGGTCAGGGTC GCAGGGTCAGGGTCAGGGTC 11: 6,599,750 probably benign Het
Nacad T C 11: 6,601,622 N523S probably benign Het
Nacad A G 11: 6,601,632 C520R probably benign Het
Nefh G A 11: 4,940,151 P823S probably benign Het
Nfrkb G C 9: 31,397,083 A230P probably benign Het
Nlrp4a A G 7: 26,449,637 E223G probably damaging Het
Notch3 T A 17: 32,146,417 Y1107F probably damaging Het
Olfr1331 G T 4: 118,869,303 R174M probably benign Het
Olfr309 A T 7: 86,306,284 Y276* probably null Het
Olfr781 A G 10: 129,333,445 D188G probably benign Het
Osm A G 11: 4,239,588 D124G probably benign Het
Plekhm2 TTCCTCCTCCT TTCCTCCT 4: 141,631,981 probably benign Het
Pomgnt1 C T 4: 116,137,427 probably benign Het
Spen A G 4: 141,474,353 V2321A probably benign Het
Sytl1 TCTGC TC 4: 133,256,994 probably benign Het
Tcn2 G C 11: 3,923,487 F286L possibly damaging Het
Tg T C 15: 66,688,863 S10P probably benign Het
Tmprss7 C T 16: 45,680,733 R235Q probably benign Het
Tns3 G T 11: 8,451,146 L1051M probably benign Het
Tns3 T G 11: 8,479,518 E806A probably benign Het
Tns3 G A 11: 8,549,100 probably benign Het
Toe1 T C 4: 116,806,093 I62M probably benign Het
Txnrd2 A G 16: 18,475,565 H436R probably damaging Het
Ubr4 C T 4: 139,451,781 P2001S probably damaging Het
Vmn2r23 T A 6: 123,713,161 M332K probably benign Het
Zbtb8a GG GGATG 4: 129,360,019 probably benign Het
Zbtb8a T C 4: 129,360,212 H163R probably benign Het
Zfyve21 A G 12: 111,827,633 D206G probably damaging Het
Zkscan4 AGAGGAG AGAG 13: 21,479,200 probably benign Het
Zmym1 C T 4: 127,047,947 D785N probably benign Het
Zmym1 C T 4: 127,048,250 V684I probably benign Het
Zmym1 A C 4: 127,049,673 H307Q probably benign Het
Other mutations in Ctrc
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01137:Ctrc APN 4 141838754 missense possibly damaging 0.84
IGL01727:Ctrc APN 4 141843761 missense probably damaging 1.00
IGL02085:Ctrc APN 4 141843714 missense possibly damaging 0.79
IGL02413:Ctrc APN 4 141843717 missense possibly damaging 0.87
IGL02945:Ctrc APN 4 141846252 missense possibly damaging 0.93
R0625:Ctrc UTSW 4 141841518 missense probably damaging 1.00
R1458:Ctrc UTSW 4 141846224 splice site probably null
R1460:Ctrc UTSW 4 141838809 intron probably benign
R3937:Ctrc UTSW 4 141840321 missense probably damaging 1.00
R4724:Ctrc UTSW 4 141846296 unclassified probably null
R4750:Ctrc UTSW 4 141841523 missense probably benign 0.38
R5207:Ctrc UTSW 4 141840384 missense probably damaging 0.97
R5326:Ctrc UTSW 4 141843726 missense probably damaging 0.96
R5542:Ctrc UTSW 4 141843726 missense probably damaging 0.96
R5641:Ctrc UTSW 4 141838783 missense probably damaging 0.97
R5872:Ctrc UTSW 4 141845043 missense probably damaging 1.00
R6932:Ctrc UTSW 4 141841568 missense probably damaging 1.00
R7329:Ctrc UTSW 4 141843711 missense probably benign 0.17
R7485:Ctrc UTSW 4 141840316 missense probably damaging 1.00
R8001:Ctrc UTSW 4 141840360 missense probably damaging 1.00
R8117:Ctrc UTSW 4 141838661 missense probably damaging 1.00
T0722:Ctrc UTSW 4 141845196 frame shift probably null
Predicted Primers
Posted On2015-02-04