Mutagenetix > Incidental Mutation

Incidental Mutation 'T0975:Osm'

262171

Institutional Source

Beutler Lab

Gene Symbol

Osm

Ensembl Gene

ENSMUSG00000058755

Gene Name

oncostatin M

Synonyms

OncoM

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

T0975 (G3) of strain 714

Quality Score

188

Status

Not validated

Chromosome

Chromosomal Location

4236420-4241026 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 4239588 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 124 (D124G)

Ref Sequence

ENSEMBL: ENSMUSP00000074708 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075221]

AlphaFold

P53347

Predicted Effect

probably benign
Transcript: ENSMUST00000075221
AA Change: D124G

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)

SMART Domains

Protein: ENSMUSP00000074708
Gene: ENSMUSG00000058755
AA Change: D124G

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
LIF_OSM	28	183	7.44e-92	SMART
low complexity region	203	214	N/A	INTRINSIC
low complexity region	217	245	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000131764

Coding Region Coverage

1x: 99.4%
3x: 98.7%
10x: 97.0%
20x: 93.3%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
PHENOTYPE: Homozygous mutant mice display decreased noxious responses in models of acute thermal, mechanical, chemical, and visceral pain. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 67 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930556J24Rik	TAA	TAAA	11: 3,937,945		probably null	Het
4930556J24Rik	C	T	11: 3,976,324	A27T	unknown	Het
Ago3	C	T	4: 126,404,263	V155I	probably benign	Het
Ago3	C	T	4: 126,404,305	A141T	probably benign	Het
Ago3	G	A	4: 126,404,310	A139V	probably benign	Het
Ahdc1	ACCTCCT	ACCTCCTCCT	4: 133,062,754		probably benign	Het
Azin2	A	G	4: 128,946,134	Y222H	probably benign	Het
Bpifb5	C	A	2: 154,229,464		probably null	Het
Ccdc157	C	T	11: 4,146,246	A455T	probably damaging	Het
Ccng1	A	C	11: 40,754,044	S9A	probably benign	Het
Cfh	T	C	1: 140,154,598	T164A	probably benign	Het
Cherp	TTGGACCTGGACCTGGACCTGGACCTGGA	TTGGACCTGGACCTGGACCTGGA	8: 72,462,034		probably benign	Het
Chrng	T	C	1: 87,210,626	S380P	probably benign	Het
Clspn	ACGGCGGCGGCGGCG	ACGGCGGCGGCGGCGGCGGCG	4: 126,566,437		probably benign	Het
Ctrc	T	TA	4: 141,845,196		probably null	Het
Cxxc1	C	T	18: 74,220,921	R593C	probably damaging	Het
Dlgap1	T	C	17: 70,516,955	S312P	possibly damaging	Het
Dnah10	A	G	5: 124,763,066	S1255G	probably benign	Het
Dpep1	A	T	8: 123,200,988	S388C	probably damaging	Het
Emid1	A	C	11: 5,128,884	L353V	probably benign	Het
Emid1	T	C	11: 5,144,386	T42A	probably damaging	Het
Epn3	A	G	11: 94,491,907		probably null	Het
Fam124b	T	C	1: 80,213,126	E180G	probably benign	Het
Fam135b	T	G	15: 71,463,885	T487P	probably damaging	Het
Gatsl3	G	C	11: 4,220,445	G147A	probably benign	Het
Gja4	G	C	4: 127,312,231	H246Q	probably benign	Het
Gm7534	GTG	GTGCTG	4: 134,202,629		probably benign	Het
Gm9972	GA	GAA	11: 43,036,770		probably null	Het
Hmmr	G	C	11: 40,723,416	N148K	probably damaging	Het
Homez	C	T	14: 54,857,339	R304K	possibly damaging	Het
Ifngr1	G	A	10: 19,609,473	V407M	probably damaging	Het
Inpp5j	G	T	11: 3,502,527	T241N	possibly damaging	Het
Kif12	GGGGC	GGGGCCTCCACCCGGCGGGC	4: 63,171,423		probably benign	Het
Kremen1	C	T	11: 5,195,105	A424T	probably benign	Het
Mat2b	G	A	11: 40,680,091	T302I	probably benign	Het
Mtmr3	C	T	11: 4,488,441	R671K	probably benign	Het
Nacad	GCAGGGTCAGGGTC	GCAGGGTCAGGGTCAGGGTC	11: 6,599,750		probably benign	Het
Nacad	T	C	11: 6,601,622	N523S	probably benign	Het
Nacad	A	G	11: 6,601,632	C520R	probably benign	Het
Nefh	G	A	11: 4,940,151	P823S	probably benign	Het
Nfrkb	G	C	9: 31,397,083	A230P	probably benign	Het
Nlrp4a	A	G	7: 26,449,637	E223G	probably damaging	Het
Notch3	T	A	17: 32,146,417	Y1107F	probably damaging	Het
Olfr1331	G	T	4: 118,869,303	R174M	probably benign	Het
Olfr309	A	T	7: 86,306,284	Y276*	probably null	Het
Olfr781	A	G	10: 129,333,445	D188G	probably benign	Het
Plekhm2	TTCCTCCTCCT	TTCCTCCT	4: 141,631,981		probably benign	Het
Pomgnt1	C	T	4: 116,137,427		probably benign	Het
Spen	A	G	4: 141,474,353	V2321A	probably benign	Het
Sytl1	TCTGC	TC	4: 133,256,994		probably benign	Het
Tcn2	G	C	11: 3,923,487	F286L	possibly damaging	Het
Tg	T	C	15: 66,688,863	S10P	probably benign	Het
Tmprss7	C	T	16: 45,680,733	R235Q	probably benign	Het
Tns3	G	T	11: 8,451,146	L1051M	probably benign	Het
Tns3	T	G	11: 8,479,518	E806A	probably benign	Het
Tns3	G	A	11: 8,549,100		probably benign	Het
Toe1	T	C	4: 116,806,093	I62M	probably benign	Het
Txnrd2	A	G	16: 18,475,565	H436R	probably damaging	Het
Ubr4	C	T	4: 139,451,781	P2001S	probably damaging	Het
Vmn2r23	T	A	6: 123,713,161	M332K	probably benign	Het
Zbtb8a	GG	GGATG	4: 129,360,019		probably benign	Het
Zbtb8a	T	C	4: 129,360,212	H163R	probably benign	Het
Zfyve21	A	G	12: 111,827,633	D206G	probably damaging	Het
Zkscan4	AGAGGAG	AGAG	13: 21,479,200		probably benign	Het
Zmym1	C	T	4: 127,047,947	D785N	probably benign	Het
Zmym1	C	T	4: 127,048,250	V684I	probably benign	Het
Zmym1	A	C	4: 127,049,673	H307Q	probably benign	Het

Other mutations in Osm

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02007:Osm	APN	11	4239470	missense	probably damaging	0.99
IGL02477:Osm	APN	11	4239604	missense	probably damaging	0.99
IGL02478:Osm	APN	11	4239507	missense	probably damaging	0.96
IGL02699:Osm	APN	11	4239723	missense	possibly damaging	0.45
IGL03328:Osm	APN	11	4238426	missense	unknown
R0212:Osm	UTSW	11	4238465	missense	probably benign	0.12
R0667:Osm	UTSW	11	4239918	missense	possibly damaging	0.53
R2237:Osm	UTSW	11	4238505	missense	possibly damaging	0.95
R4790:Osm	UTSW	11	4238435	missense	probably benign	0.01
R6621:Osm	UTSW	11	4239541	missense	probably benign	0.03
R7148:Osm	UTSW	11	4239936	missense	probably benign	0.02
R8669:Osm	UTSW	11	4239665	missense	probably benign	0.04
R8805:Osm	UTSW	11	4239839	missense	probably benign	0.18
R9205:Osm	UTSW	11	4238504	missense	possibly damaging	0.95
R9673:Osm	UTSW	11	4239926	missense	probably benign	0.00

Predicted Primers

Posted On

2015-02-04