Incidental Mutation 'R0834:Tube1'
ID262278
Institutional Source Beutler Lab
Gene Symbol Tube1
Ensembl Gene ENSMUSG00000019845
Gene Nameepsilon-tubulin 1
Synonyms
MMRRC Submission 039013-MU
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.931) question?
Stock #R0834 (G1)
Quality Score225
Status Not validated
Chromosome10
Chromosomal Location39133976-39152542 bp(+) (GRCm38)
Type of Mutationintron
DNA Base Change (assembly) T to A at 39134172 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000019991 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019991] [ENSMUST00000063204] [ENSMUST00000124941] [ENSMUST00000125042] [ENSMUST00000134279] [ENSMUST00000135785] [ENSMUST00000139743] [ENSMUST00000149949] [ENSMUST00000213459]
Predicted Effect probably null
Transcript: ENSMUST00000019991
SMART Domains Protein: ENSMUSP00000019991
Gene: ENSMUSG00000019845

DomainStartEndE-ValueType
Tubulin 55 277 1.08e-38 SMART
Tubulin_C 279 414 9.81e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000063204
SMART Domains Protein: ENSMUSP00000063508
Gene: ENSMUSG00000051736

DomainStartEndE-ValueType
Pfam:UPF0731 2 80 4.8e-49 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000124941
SMART Domains Protein: ENSMUSP00000123540
Gene: ENSMUSG00000051736

DomainStartEndE-ValueType
Pfam:UPF0731 2 80 4.8e-49 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000125042
SMART Domains Protein: ENSMUSP00000121708
Gene: ENSMUSG00000051736

DomainStartEndE-ValueType
Pfam:UPF0731 2 48 3.6e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000134279
SMART Domains Protein: ENSMUSP00000118858
Gene: ENSMUSG00000051736

DomainStartEndE-ValueType
Pfam:UPF0731 2 80 4.8e-49 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000135785
SMART Domains Protein: ENSMUSP00000118928
Gene: ENSMUSG00000051736

DomainStartEndE-ValueType
Pfam:UPF0731 2 80 4.8e-49 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000139743
SMART Domains Protein: ENSMUSP00000118545
Gene: ENSMUSG00000051736

DomainStartEndE-ValueType
Pfam:UPF0731 3 80 4.6e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000149949
SMART Domains Protein: ENSMUSP00000121946
Gene: ENSMUSG00000051736

DomainStartEndE-ValueType
Pfam:UPF0731 2 80 4.8e-49 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154981
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213237
Predicted Effect probably benign
Transcript: ENSMUST00000213459
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213898
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217214
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.7%
  • 20x: 95.7%
Validation Efficiency 100% (86/86)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in organization of the microtubules during centriole duplication. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Jan 2009]
Allele List at MGI
Other mutations in this stock
Total: 85 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900011O08Rik T C 16: 14,093,931 L47P probably damaging Het
Add2 A T 6: 86,086,917 E66V probably damaging Het
Aldh1a3 T C 7: 66,412,910 I156V probably benign Het
Ang4 T A 14: 51,764,268 K74N probably benign Het
Arcn1 A T 9: 44,758,875 probably benign Het
Arhgef33 T A 17: 80,347,597 probably benign Het
Arntl2 A G 6: 146,822,687 H359R probably damaging Het
Atn1 A G 6: 124,743,225 probably benign Het
Brip1 T C 11: 86,192,827 T123A probably benign Het
Camkv A G 9: 107,945,846 Y95C probably damaging Het
Cdk12 T A 11: 98,204,385 S340T probably benign Het
Ckap2l G A 2: 129,296,304 probably benign Het
Clmn A T 12: 104,771,826 L1042Q probably damaging Het
Clmn G T 12: 104,771,827 L1042M probably damaging Het
Cluh T C 11: 74,663,805 V737A probably benign Het
Cpne8 A G 15: 90,540,259 V309A probably benign Het
Cpxm2 T A 7: 132,154,613 probably benign Het
Csmd3 A T 15: 47,883,677 probably benign Het
Ctr9 T A 7: 111,050,952 S818T probably benign Het
Cyp26a1 C T 19: 37,699,957 A309V probably damaging Het
D10Jhu81e T C 10: 78,162,705 D229G probably damaging Het
Dbndd2 C T 2: 164,490,202 T115I possibly damaging Het
Ddx58 T A 4: 40,239,596 E34V possibly damaging Het
Dhcr7 A G 7: 143,841,227 N157S probably benign Het
Dlx2 C A 2: 71,545,515 V155F probably damaging Het
Duox1 A T 2: 122,346,501 I1470F probably damaging Het
Esrrb A T 12: 86,470,297 I68F probably benign Het
Fhod3 T A 18: 25,115,805 L1347* probably null Het
Fip1l1 T C 5: 74,595,060 probably benign Het
Frem3 A G 8: 80,687,008 Y1966C probably damaging Het
Ggt5 C T 10: 75,604,770 R242C possibly damaging Het
Gm14496 G A 2: 181,995,687 V185I probably benign Het
Gnptab T C 10: 88,429,952 V409A probably damaging Het
Gramd1a A G 7: 31,138,164 F390S possibly damaging Het
Helz2 A G 2: 181,230,777 S2477P probably damaging Het
Hsd17b3 T C 13: 64,089,122 K3E probably benign Het
Ift172 T C 5: 31,257,371 H1395R probably benign Het
Jam2 T A 16: 84,812,967 C180S probably damaging Het
Kalrn A C 16: 34,049,919 S160A possibly damaging Het
Kcnk3 T C 5: 30,622,635 I343T probably damaging Het
Kif13a T C 13: 46,814,236 E334G probably damaging Het
Klhl41 A G 2: 69,678,147 K482E possibly damaging Het
Lig3 A G 11: 82,798,287 E794G probably damaging Het
Myh13 T C 11: 67,349,610 M780T possibly damaging Het
Ndst2 A G 14: 20,729,693 Y160H probably damaging Het
Ndufb10 T C 17: 24,722,674 M90V probably damaging Het
Obscn T C 11: 59,133,278 K522R probably benign Het
Olfml2b T C 1: 170,647,844 S113P probably benign Het
Olfr1251 A G 2: 89,667,079 I269T probably benign Het
Olfr1424 T A 19: 12,059,615 M46L probably benign Het
Olfr298 T A 7: 86,489,490 E20D probably benign Het
Olfr420 T A 1: 174,159,364 M197K possibly damaging Het
Olfr620 T C 7: 103,612,237 T39A probably benign Het
Parg T C 14: 32,214,554 probably benign Het
Pde7a C T 3: 19,230,318 C367Y probably damaging Het
Pigr T A 1: 130,844,544 C166* probably null Het
Pip4k2c A T 10: 127,200,835 probably benign Het
Ppp1r16a C T 15: 76,693,669 Q328* probably null Het
Prkd2 A T 7: 16,865,677 probably benign Het
Ptprt G T 2: 161,812,139 probably null Het
Rapgef5 C T 12: 117,647,121 probably benign Het
Retreg1 T C 15: 25,971,670 L356P probably benign Het
Rnf43 A G 11: 87,731,251 T393A probably benign Het
Samd3 T C 10: 26,271,827 S467P probably benign Het
Scarf1 C A 11: 75,514,403 C89* probably null Het
Sdk1 T C 5: 141,242,024 L59S probably benign Het
Sgca C T 11: 94,970,686 W244* probably null Het
Sh3d21 T C 4: 126,151,272 K538R probably benign Het
Smyd4 T A 11: 75,391,132 L477Q possibly damaging Het
Sra1 A G 18: 36,668,776 M87T probably benign Het
Ssh2 T C 11: 77,437,633 Y336H possibly damaging Het
Steap1 T C 5: 5,740,357 Y197C probably damaging Het
Strn3 A G 12: 51,627,096 probably benign Het
Tgm3 A G 2: 130,026,757 T205A probably benign Het
Tll2 G A 19: 41,113,073 T374I probably damaging Het
Tmem63b C A 17: 45,660,944 D782Y possibly damaging Het
Trim10 G A 17: 36,872,391 S193N probably benign Het
Ttf1 A T 2: 29,073,950 K613* probably null Het
Uimc1 T A 13: 55,076,409 probably null Het
Wwp2 G T 8: 107,556,796 probably benign Het
Zfp101 C T 17: 33,382,444 V113I probably benign Het
Zfp292 T C 4: 34,809,114 D1310G probably benign Het
Zfp575 A T 7: 24,585,820 L132H probably damaging Het
Zmym2 T C 14: 56,956,963 F1226S probably damaging Het
Zswim6 A C 13: 107,726,454 noncoding transcript Het
Other mutations in Tube1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01457:Tube1 APN 10 39145722 splice site probably benign
IGL01977:Tube1 APN 10 39135045 splice site probably benign
IGL02437:Tube1 APN 10 39140850 missense probably damaging 1.00
IGL03251:Tube1 APN 10 39134981 splice site probably benign
R0145:Tube1 UTSW 10 39145602 missense possibly damaging 0.89
R0544:Tube1 UTSW 10 39140945 splice site probably null
R1251:Tube1 UTSW 10 39134208 nonsense probably null
R1557:Tube1 UTSW 10 39145715 critical splice donor site probably null
R1607:Tube1 UTSW 10 39144766 missense possibly damaging 0.89
R2138:Tube1 UTSW 10 39147351 missense probably benign 0.04
R2367:Tube1 UTSW 10 39144919 missense probably damaging 1.00
R4209:Tube1 UTSW 10 39144934 splice site probably null
R4646:Tube1 UTSW 10 39142367 missense possibly damaging 0.63
R4840:Tube1 UTSW 10 39144846 missense probably benign 0.06
R5267:Tube1 UTSW 10 39144556 missense probably benign 0.00
R6331:Tube1 UTSW 10 39134101 missense probably benign 0.01
R7602:Tube1 UTSW 10 39142266 missense probably benign 0.33
R7778:Tube1 UTSW 10 39142298 missense probably benign 0.25
R7824:Tube1 UTSW 10 39142298 missense probably benign 0.25
X0023:Tube1 UTSW 10 39144762 missense probably benign 0.00
Predicted Primers
Posted On2015-02-04