Incidental Mutation 'R1034:Zfp758'
ID |
262398 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zfp758
|
Ensembl Gene |
ENSMUSG00000044501 |
Gene Name |
zinc finger protein 758 |
Synonyms |
|
MMRRC Submission |
039133-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.100)
|
Stock # |
R1034 (G1)
|
Quality Score |
107 |
Status
|
Not validated
|
Chromosome |
17 |
Chromosomal Location |
22580434-22596262 bp(+) (GRCm39) |
Type of Mutation |
nonsense |
DNA Base Change (assembly) |
G to T
at 22594740 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Glutamic Acid to Stop codon
at position 409
(E409*)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000121288
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000072477]
[ENSMUST00000088765]
[ENSMUST00000121315]
[ENSMUST00000149699]
|
AlphaFold |
E9QAA1 |
Predicted Effect |
probably null
Transcript: ENSMUST00000072477
AA Change: E377*
|
SMART Domains |
Protein: ENSMUSP00000072298 Gene: ENSMUSG00000044501 AA Change: E377*
Domain | Start | End | E-Value | Type |
KRAB
|
13 |
73 |
1.55e-20 |
SMART |
ZnF_C2H2
|
177 |
199 |
6.92e0 |
SMART |
ZnF_C2H2
|
205 |
227 |
6.32e-3 |
SMART |
ZnF_C2H2
|
233 |
255 |
1.2e-3 |
SMART |
ZnF_C2H2
|
261 |
283 |
9.08e-4 |
SMART |
ZnF_C2H2
|
289 |
311 |
6.08e-5 |
SMART |
ZnF_C2H2
|
317 |
339 |
1.03e-2 |
SMART |
ZnF_C2H2
|
345 |
367 |
2.24e-3 |
SMART |
ZnF_C2H2
|
373 |
395 |
3.21e-4 |
SMART |
ZnF_C2H2
|
401 |
423 |
6.32e-3 |
SMART |
ZnF_C2H2
|
429 |
451 |
2.24e-3 |
SMART |
ZnF_C2H2
|
457 |
479 |
5.14e-3 |
SMART |
ZnF_C2H2
|
485 |
507 |
1.04e-3 |
SMART |
ZnF_C2H2
|
513 |
535 |
4.4e-2 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000088765
AA Change: E377*
|
SMART Domains |
Protein: ENSMUSP00000086143 Gene: ENSMUSG00000044501 AA Change: E377*
Domain | Start | End | E-Value | Type |
KRAB
|
13 |
73 |
1.55e-20 |
SMART |
ZnF_C2H2
|
177 |
199 |
6.92e0 |
SMART |
ZnF_C2H2
|
205 |
227 |
6.32e-3 |
SMART |
ZnF_C2H2
|
233 |
255 |
1.2e-3 |
SMART |
ZnF_C2H2
|
261 |
283 |
9.08e-4 |
SMART |
ZnF_C2H2
|
289 |
311 |
6.08e-5 |
SMART |
ZnF_C2H2
|
317 |
339 |
1.03e-2 |
SMART |
ZnF_C2H2
|
345 |
367 |
2.24e-3 |
SMART |
ZnF_C2H2
|
373 |
395 |
3.21e-4 |
SMART |
ZnF_C2H2
|
401 |
423 |
6.32e-3 |
SMART |
ZnF_C2H2
|
429 |
451 |
2.24e-3 |
SMART |
ZnF_C2H2
|
457 |
479 |
5.14e-3 |
SMART |
ZnF_C2H2
|
485 |
507 |
1.04e-3 |
SMART |
ZnF_C2H2
|
513 |
535 |
4.4e-2 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000121315
AA Change: E377*
|
SMART Domains |
Protein: ENSMUSP00000113532 Gene: ENSMUSG00000044501 AA Change: E377*
Domain | Start | End | E-Value | Type |
KRAB
|
13 |
73 |
1.55e-20 |
SMART |
ZnF_C2H2
|
177 |
199 |
6.92e0 |
SMART |
ZnF_C2H2
|
205 |
227 |
6.32e-3 |
SMART |
ZnF_C2H2
|
233 |
255 |
1.2e-3 |
SMART |
ZnF_C2H2
|
261 |
283 |
9.08e-4 |
SMART |
ZnF_C2H2
|
289 |
311 |
6.08e-5 |
SMART |
ZnF_C2H2
|
317 |
339 |
1.03e-2 |
SMART |
ZnF_C2H2
|
345 |
367 |
2.24e-3 |
SMART |
ZnF_C2H2
|
373 |
395 |
3.21e-4 |
SMART |
ZnF_C2H2
|
401 |
423 |
6.32e-3 |
SMART |
ZnF_C2H2
|
429 |
451 |
2.24e-3 |
SMART |
ZnF_C2H2
|
457 |
479 |
5.14e-3 |
SMART |
ZnF_C2H2
|
485 |
507 |
1.04e-3 |
SMART |
ZnF_C2H2
|
513 |
535 |
4.4e-2 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000149699
AA Change: E409*
|
SMART Domains |
Protein: ENSMUSP00000121288 Gene: ENSMUSG00000044501 AA Change: E409*
Domain | Start | End | E-Value | Type |
KRAB
|
45 |
105 |
1.55e-20 |
SMART |
ZnF_C2H2
|
209 |
231 |
6.92e0 |
SMART |
ZnF_C2H2
|
237 |
259 |
6.32e-3 |
SMART |
ZnF_C2H2
|
265 |
287 |
1.2e-3 |
SMART |
ZnF_C2H2
|
293 |
315 |
9.08e-4 |
SMART |
ZnF_C2H2
|
321 |
343 |
6.08e-5 |
SMART |
ZnF_C2H2
|
349 |
371 |
1.03e-2 |
SMART |
ZnF_C2H2
|
377 |
399 |
2.24e-3 |
SMART |
ZnF_C2H2
|
405 |
427 |
3.21e-4 |
SMART |
ZnF_C2H2
|
433 |
455 |
6.32e-3 |
SMART |
ZnF_C2H2
|
461 |
483 |
2.24e-3 |
SMART |
ZnF_C2H2
|
489 |
511 |
5.14e-3 |
SMART |
ZnF_C2H2
|
517 |
539 |
1.04e-3 |
SMART |
ZnF_C2H2
|
545 |
567 |
4.4e-2 |
SMART |
|
Coding Region Coverage |
- 1x: 98.7%
- 3x: 97.3%
- 10x: 92.9%
- 20x: 82.2%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 34 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aasdh |
G |
A |
5: 77,024,130 (GRCm39) |
T174M |
probably damaging |
Het |
Abca14 |
T |
C |
7: 119,815,370 (GRCm39) |
F206S |
probably damaging |
Het |
Arid2 |
T |
C |
15: 96,267,386 (GRCm39) |
V622A |
probably benign |
Het |
Asic1 |
T |
A |
15: 99,595,939 (GRCm39) |
L437Q |
probably damaging |
Het |
Atp1b1 |
C |
T |
1: 164,281,057 (GRCm39) |
|
probably null |
Het |
B3gnt5 |
A |
G |
16: 19,588,234 (GRCm39) |
Y151C |
probably damaging |
Het |
Cbx4 |
A |
G |
11: 118,972,533 (GRCm39) |
S281P |
probably damaging |
Het |
Dnah5 |
G |
A |
15: 28,302,617 (GRCm39) |
V1625I |
probably damaging |
Het |
Eftud2 |
A |
C |
11: 102,740,010 (GRCm39) |
D461E |
probably benign |
Het |
Epgn |
A |
G |
5: 91,180,080 (GRCm39) |
Y74C |
probably damaging |
Het |
Fcho1 |
C |
T |
8: 72,165,204 (GRCm39) |
A418T |
probably benign |
Het |
Fgf14 |
C |
T |
14: 124,369,946 (GRCm39) |
V113I |
probably damaging |
Het |
Ggcx |
G |
A |
6: 72,391,814 (GRCm39) |
R68H |
probably damaging |
Het |
Gm1110 |
A |
G |
9: 26,832,646 (GRCm39) |
S16P |
probably damaging |
Het |
Gm6729 |
T |
C |
10: 86,375,890 (GRCm39) |
|
noncoding transcript |
Het |
Gpr108 |
A |
G |
17: 57,542,995 (GRCm39) |
F522S |
probably damaging |
Het |
Gpr156 |
T |
C |
16: 37,825,088 (GRCm39) |
V435A |
probably benign |
Het |
Khdrbs2 |
T |
C |
1: 32,506,872 (GRCm39) |
L172P |
probably damaging |
Het |
Kmo |
C |
T |
1: 175,479,184 (GRCm39) |
P240L |
possibly damaging |
Het |
Ltn1 |
A |
T |
16: 87,194,025 (GRCm39) |
|
probably null |
Het |
Nbeal1 |
T |
A |
1: 60,329,165 (GRCm39) |
Y2194* |
probably null |
Het |
Or6c8 |
T |
A |
10: 128,915,830 (GRCm39) |
M1L |
probably benign |
Het |
Or7d11 |
A |
T |
9: 19,966,661 (GRCm39) |
S33T |
probably benign |
Het |
Rab6b |
T |
C |
9: 103,044,323 (GRCm39) |
S172P |
probably benign |
Het |
Ror1 |
T |
A |
4: 100,190,817 (GRCm39) |
L58* |
probably null |
Het |
Sec23b |
A |
G |
2: 144,432,258 (GRCm39) |
D756G |
possibly damaging |
Het |
Slc24a2 |
T |
A |
4: 86,950,512 (GRCm39) |
K428N |
probably damaging |
Het |
Spen |
C |
A |
4: 141,203,063 (GRCm39) |
V1855L |
probably benign |
Het |
Srgap1 |
G |
A |
10: 121,621,350 (GRCm39) |
P1071S |
possibly damaging |
Het |
Tns1 |
A |
G |
1: 73,981,128 (GRCm39) |
C1079R |
probably damaging |
Het |
Traf3ip1 |
G |
T |
1: 91,446,041 (GRCm39) |
|
probably null |
Het |
Trmt2a |
T |
C |
16: 18,067,573 (GRCm39) |
F82S |
probably damaging |
Het |
Xrn1 |
A |
G |
9: 95,921,790 (GRCm39) |
D1401G |
probably damaging |
Het |
Zfp352 |
T |
A |
4: 90,112,393 (GRCm39) |
S178T |
possibly damaging |
Het |
|
Other mutations in Zfp758 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01550:Zfp758
|
APN |
17 |
22,594,021 (GRCm39) |
missense |
probably damaging |
1.00 |
R1187:Zfp758
|
UTSW |
17 |
22,594,171 (GRCm39) |
missense |
probably benign |
0.23 |
R1733:Zfp758
|
UTSW |
17 |
22,594,830 (GRCm39) |
missense |
probably damaging |
1.00 |
R1847:Zfp758
|
UTSW |
17 |
22,594,204 (GRCm39) |
missense |
probably benign |
0.19 |
R1927:Zfp758
|
UTSW |
17 |
22,594,823 (GRCm39) |
missense |
probably damaging |
0.99 |
R1934:Zfp758
|
UTSW |
17 |
22,592,633 (GRCm39) |
missense |
probably damaging |
0.99 |
R2113:Zfp758
|
UTSW |
17 |
22,580,626 (GRCm39) |
missense |
probably benign |
0.10 |
R2132:Zfp758
|
UTSW |
17 |
22,594,951 (GRCm39) |
missense |
probably damaging |
1.00 |
R5134:Zfp758
|
UTSW |
17 |
22,594,386 (GRCm39) |
missense |
probably damaging |
1.00 |
R5274:Zfp758
|
UTSW |
17 |
22,594,836 (GRCm39) |
missense |
probably benign |
0.31 |
R5303:Zfp758
|
UTSW |
17 |
22,593,842 (GRCm39) |
missense |
probably benign |
0.05 |
R5394:Zfp758
|
UTSW |
17 |
22,591,049 (GRCm39) |
missense |
probably damaging |
0.99 |
R5813:Zfp758
|
UTSW |
17 |
22,594,796 (GRCm39) |
missense |
probably damaging |
1.00 |
R6017:Zfp758
|
UTSW |
17 |
22,592,712 (GRCm39) |
missense |
probably damaging |
1.00 |
R6411:Zfp758
|
UTSW |
17 |
22,594,075 (GRCm39) |
missense |
possibly damaging |
0.85 |
R6501:Zfp758
|
UTSW |
17 |
22,590,978 (GRCm39) |
intron |
probably benign |
|
R6805:Zfp758
|
UTSW |
17 |
22,580,650 (GRCm39) |
missense |
probably benign |
0.00 |
R7076:Zfp758
|
UTSW |
17 |
22,594,137 (GRCm39) |
missense |
probably benign |
0.11 |
R7147:Zfp758
|
UTSW |
17 |
22,594,981 (GRCm39) |
missense |
possibly damaging |
0.75 |
R7170:Zfp758
|
UTSW |
17 |
22,594,116 (GRCm39) |
nonsense |
probably null |
|
R7572:Zfp758
|
UTSW |
17 |
22,593,872 (GRCm39) |
missense |
possibly damaging |
0.61 |
R7593:Zfp758
|
UTSW |
17 |
22,593,939 (GRCm39) |
missense |
probably damaging |
0.98 |
R7699:Zfp758
|
UTSW |
17 |
22,594,646 (GRCm39) |
nonsense |
probably null |
|
R7858:Zfp758
|
UTSW |
17 |
22,594,359 (GRCm39) |
missense |
probably benign |
0.02 |
R9377:Zfp758
|
UTSW |
17 |
22,593,925 (GRCm39) |
missense |
probably benign |
0.35 |
R9717:Zfp758
|
UTSW |
17 |
22,593,829 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
Predicted Primers |
|
Posted On |
2015-02-04 |