Incidental Mutation 'R1034:Zfp758'
ID 262398
Institutional Source Beutler Lab
Gene Symbol Zfp758
Ensembl Gene ENSMUSG00000044501
Gene Name zinc finger protein 758
Synonyms
MMRRC Submission 039133-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.100) question?
Stock # R1034 (G1)
Quality Score 107
Status Not validated
Chromosome 17
Chromosomal Location 22580434-22596262 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 22594740 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Stop codon at position 409 (E409*)
Ref Sequence ENSEMBL: ENSMUSP00000121288 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072477] [ENSMUST00000088765] [ENSMUST00000121315] [ENSMUST00000149699]
AlphaFold E9QAA1
Predicted Effect probably null
Transcript: ENSMUST00000072477
AA Change: E377*
SMART Domains Protein: ENSMUSP00000072298
Gene: ENSMUSG00000044501
AA Change: E377*

DomainStartEndE-ValueType
KRAB 13 73 1.55e-20 SMART
ZnF_C2H2 177 199 6.92e0 SMART
ZnF_C2H2 205 227 6.32e-3 SMART
ZnF_C2H2 233 255 1.2e-3 SMART
ZnF_C2H2 261 283 9.08e-4 SMART
ZnF_C2H2 289 311 6.08e-5 SMART
ZnF_C2H2 317 339 1.03e-2 SMART
ZnF_C2H2 345 367 2.24e-3 SMART
ZnF_C2H2 373 395 3.21e-4 SMART
ZnF_C2H2 401 423 6.32e-3 SMART
ZnF_C2H2 429 451 2.24e-3 SMART
ZnF_C2H2 457 479 5.14e-3 SMART
ZnF_C2H2 485 507 1.04e-3 SMART
ZnF_C2H2 513 535 4.4e-2 SMART
Predicted Effect probably null
Transcript: ENSMUST00000088765
AA Change: E377*
SMART Domains Protein: ENSMUSP00000086143
Gene: ENSMUSG00000044501
AA Change: E377*

DomainStartEndE-ValueType
KRAB 13 73 1.55e-20 SMART
ZnF_C2H2 177 199 6.92e0 SMART
ZnF_C2H2 205 227 6.32e-3 SMART
ZnF_C2H2 233 255 1.2e-3 SMART
ZnF_C2H2 261 283 9.08e-4 SMART
ZnF_C2H2 289 311 6.08e-5 SMART
ZnF_C2H2 317 339 1.03e-2 SMART
ZnF_C2H2 345 367 2.24e-3 SMART
ZnF_C2H2 373 395 3.21e-4 SMART
ZnF_C2H2 401 423 6.32e-3 SMART
ZnF_C2H2 429 451 2.24e-3 SMART
ZnF_C2H2 457 479 5.14e-3 SMART
ZnF_C2H2 485 507 1.04e-3 SMART
ZnF_C2H2 513 535 4.4e-2 SMART
Predicted Effect probably null
Transcript: ENSMUST00000121315
AA Change: E377*
SMART Domains Protein: ENSMUSP00000113532
Gene: ENSMUSG00000044501
AA Change: E377*

DomainStartEndE-ValueType
KRAB 13 73 1.55e-20 SMART
ZnF_C2H2 177 199 6.92e0 SMART
ZnF_C2H2 205 227 6.32e-3 SMART
ZnF_C2H2 233 255 1.2e-3 SMART
ZnF_C2H2 261 283 9.08e-4 SMART
ZnF_C2H2 289 311 6.08e-5 SMART
ZnF_C2H2 317 339 1.03e-2 SMART
ZnF_C2H2 345 367 2.24e-3 SMART
ZnF_C2H2 373 395 3.21e-4 SMART
ZnF_C2H2 401 423 6.32e-3 SMART
ZnF_C2H2 429 451 2.24e-3 SMART
ZnF_C2H2 457 479 5.14e-3 SMART
ZnF_C2H2 485 507 1.04e-3 SMART
ZnF_C2H2 513 535 4.4e-2 SMART
Predicted Effect probably null
Transcript: ENSMUST00000149699
AA Change: E409*
SMART Domains Protein: ENSMUSP00000121288
Gene: ENSMUSG00000044501
AA Change: E409*

DomainStartEndE-ValueType
KRAB 45 105 1.55e-20 SMART
ZnF_C2H2 209 231 6.92e0 SMART
ZnF_C2H2 237 259 6.32e-3 SMART
ZnF_C2H2 265 287 1.2e-3 SMART
ZnF_C2H2 293 315 9.08e-4 SMART
ZnF_C2H2 321 343 6.08e-5 SMART
ZnF_C2H2 349 371 1.03e-2 SMART
ZnF_C2H2 377 399 2.24e-3 SMART
ZnF_C2H2 405 427 3.21e-4 SMART
ZnF_C2H2 433 455 6.32e-3 SMART
ZnF_C2H2 461 483 2.24e-3 SMART
ZnF_C2H2 489 511 5.14e-3 SMART
ZnF_C2H2 517 539 1.04e-3 SMART
ZnF_C2H2 545 567 4.4e-2 SMART
Coding Region Coverage
  • 1x: 98.7%
  • 3x: 97.3%
  • 10x: 92.9%
  • 20x: 82.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh G A 5: 77,024,130 (GRCm39) T174M probably damaging Het
Abca14 T C 7: 119,815,370 (GRCm39) F206S probably damaging Het
Arid2 T C 15: 96,267,386 (GRCm39) V622A probably benign Het
Asic1 T A 15: 99,595,939 (GRCm39) L437Q probably damaging Het
Atp1b1 C T 1: 164,281,057 (GRCm39) probably null Het
B3gnt5 A G 16: 19,588,234 (GRCm39) Y151C probably damaging Het
Cbx4 A G 11: 118,972,533 (GRCm39) S281P probably damaging Het
Dnah5 G A 15: 28,302,617 (GRCm39) V1625I probably damaging Het
Eftud2 A C 11: 102,740,010 (GRCm39) D461E probably benign Het
Epgn A G 5: 91,180,080 (GRCm39) Y74C probably damaging Het
Fcho1 C T 8: 72,165,204 (GRCm39) A418T probably benign Het
Fgf14 C T 14: 124,369,946 (GRCm39) V113I probably damaging Het
Ggcx G A 6: 72,391,814 (GRCm39) R68H probably damaging Het
Gm1110 A G 9: 26,832,646 (GRCm39) S16P probably damaging Het
Gm6729 T C 10: 86,375,890 (GRCm39) noncoding transcript Het
Gpr108 A G 17: 57,542,995 (GRCm39) F522S probably damaging Het
Gpr156 T C 16: 37,825,088 (GRCm39) V435A probably benign Het
Khdrbs2 T C 1: 32,506,872 (GRCm39) L172P probably damaging Het
Kmo C T 1: 175,479,184 (GRCm39) P240L possibly damaging Het
Ltn1 A T 16: 87,194,025 (GRCm39) probably null Het
Nbeal1 T A 1: 60,329,165 (GRCm39) Y2194* probably null Het
Or6c8 T A 10: 128,915,830 (GRCm39) M1L probably benign Het
Or7d11 A T 9: 19,966,661 (GRCm39) S33T probably benign Het
Rab6b T C 9: 103,044,323 (GRCm39) S172P probably benign Het
Ror1 T A 4: 100,190,817 (GRCm39) L58* probably null Het
Sec23b A G 2: 144,432,258 (GRCm39) D756G possibly damaging Het
Slc24a2 T A 4: 86,950,512 (GRCm39) K428N probably damaging Het
Spen C A 4: 141,203,063 (GRCm39) V1855L probably benign Het
Srgap1 G A 10: 121,621,350 (GRCm39) P1071S possibly damaging Het
Tns1 A G 1: 73,981,128 (GRCm39) C1079R probably damaging Het
Traf3ip1 G T 1: 91,446,041 (GRCm39) probably null Het
Trmt2a T C 16: 18,067,573 (GRCm39) F82S probably damaging Het
Xrn1 A G 9: 95,921,790 (GRCm39) D1401G probably damaging Het
Zfp352 T A 4: 90,112,393 (GRCm39) S178T possibly damaging Het
Other mutations in Zfp758
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01550:Zfp758 APN 17 22,594,021 (GRCm39) missense probably damaging 1.00
R1187:Zfp758 UTSW 17 22,594,171 (GRCm39) missense probably benign 0.23
R1733:Zfp758 UTSW 17 22,594,830 (GRCm39) missense probably damaging 1.00
R1847:Zfp758 UTSW 17 22,594,204 (GRCm39) missense probably benign 0.19
R1927:Zfp758 UTSW 17 22,594,823 (GRCm39) missense probably damaging 0.99
R1934:Zfp758 UTSW 17 22,592,633 (GRCm39) missense probably damaging 0.99
R2113:Zfp758 UTSW 17 22,580,626 (GRCm39) missense probably benign 0.10
R2132:Zfp758 UTSW 17 22,594,951 (GRCm39) missense probably damaging 1.00
R5134:Zfp758 UTSW 17 22,594,386 (GRCm39) missense probably damaging 1.00
R5274:Zfp758 UTSW 17 22,594,836 (GRCm39) missense probably benign 0.31
R5303:Zfp758 UTSW 17 22,593,842 (GRCm39) missense probably benign 0.05
R5394:Zfp758 UTSW 17 22,591,049 (GRCm39) missense probably damaging 0.99
R5813:Zfp758 UTSW 17 22,594,796 (GRCm39) missense probably damaging 1.00
R6017:Zfp758 UTSW 17 22,592,712 (GRCm39) missense probably damaging 1.00
R6411:Zfp758 UTSW 17 22,594,075 (GRCm39) missense possibly damaging 0.85
R6501:Zfp758 UTSW 17 22,590,978 (GRCm39) intron probably benign
R6805:Zfp758 UTSW 17 22,580,650 (GRCm39) missense probably benign 0.00
R7076:Zfp758 UTSW 17 22,594,137 (GRCm39) missense probably benign 0.11
R7147:Zfp758 UTSW 17 22,594,981 (GRCm39) missense possibly damaging 0.75
R7170:Zfp758 UTSW 17 22,594,116 (GRCm39) nonsense probably null
R7572:Zfp758 UTSW 17 22,593,872 (GRCm39) missense possibly damaging 0.61
R7593:Zfp758 UTSW 17 22,593,939 (GRCm39) missense probably damaging 0.98
R7699:Zfp758 UTSW 17 22,594,646 (GRCm39) nonsense probably null
R7858:Zfp758 UTSW 17 22,594,359 (GRCm39) missense probably benign 0.02
R9377:Zfp758 UTSW 17 22,593,925 (GRCm39) missense probably benign 0.35
R9717:Zfp758 UTSW 17 22,593,829 (GRCm39) missense possibly damaging 0.48
Predicted Primers
Posted On 2015-02-04