Incidental Mutation 'R1235:Or8w1'
ID 262460
Institutional Source Beutler Lab
Gene Symbol Or8w1
Ensembl Gene ENSMUSG00000068818
Gene Name olfactory receptor family 8 subfamily U member 1
Synonyms GA_x6K02T2Q125-49140947-49140021, MOR177-1, Olfr1132
MMRRC Submission 039303-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.143) question?
Stock # R1235 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 87465163-87466089 bp(-) (GRCm39)
Type of Mutation splice site (4 bp from exon)
DNA Base Change (assembly) T to G at 87465159 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000088213 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090711] [ENSMUST00000213302] [ENSMUST00000216082] [ENSMUST00000216756]
AlphaFold Q8VG97
Predicted Effect probably null
Transcript: ENSMUST00000090711
SMART Domains Protein: ENSMUSP00000088213
Gene: ENSMUSG00000068818

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.3e-45 PFAM
Pfam:7tm_1 41 290 4.8e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213302
Predicted Effect probably benign
Transcript: ENSMUST00000216082
Predicted Effect probably benign
Transcript: ENSMUST00000216756
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.3%
  • 20x: 89.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 18 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arsg T C 11: 109,424,933 (GRCm39) probably null Het
Col6a1 C A 10: 76,548,158 (GRCm39) A633S unknown Het
Dnajb3 C T 1: 88,133,201 (GRCm39) R67H probably benign Het
Fam53c T A 18: 34,901,311 (GRCm39) L76Q probably damaging Het
Gys2 A T 6: 142,376,019 (GRCm39) Y548N probably damaging Het
Kcnh3 T A 15: 99,139,984 (GRCm39) probably null Het
Lrp2 C T 2: 69,354,380 (GRCm39) V483I probably damaging Het
Myom3 A T 4: 135,516,854 (GRCm39) Y808F probably benign Het
Nmur1 C T 1: 86,314,415 (GRCm39) G307S probably damaging Het
Pcdhb13 T C 18: 37,578,012 (GRCm39) *797Q probably null Het
Plcb4 G A 2: 135,814,868 (GRCm39) G719R probably damaging Het
Pld1 A T 3: 28,082,883 (GRCm39) T143S probably benign Het
Rem1 G A 2: 152,476,455 (GRCm39) V238M probably damaging Het
Sema5a A T 15: 32,609,372 (GRCm39) Y426F probably benign Het
Trpc7 G T 13: 57,035,352 (GRCm39) H194N probably damaging Het
Vmn2r106 A T 17: 20,499,741 (GRCm39) F165I probably benign Het
Zdbf2 A G 1: 63,348,232 (GRCm39) T2204A possibly damaging Het
Zp2 A T 7: 119,737,566 (GRCm39) F240I possibly damaging Het
Other mutations in Or8w1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01115:Or8w1 APN 2 87,465,728 (GRCm39) missense probably damaging 1.00
IGL01780:Or8w1 APN 2 87,465,424 (GRCm39) missense possibly damaging 0.56
R1471:Or8w1 UTSW 2 87,466,014 (GRCm39) missense probably benign
R2106:Or8w1 UTSW 2 87,465,503 (GRCm39) missense probably benign 0.22
R3711:Or8w1 UTSW 2 87,466,025 (GRCm39) missense probably benign
R4024:Or8w1 UTSW 2 87,465,499 (GRCm39) missense probably damaging 0.97
R4522:Or8w1 UTSW 2 87,465,495 (GRCm39) missense probably benign
R6531:Or8w1 UTSW 2 87,465,873 (GRCm39) missense probably damaging 1.00
R7768:Or8w1 UTSW 2 87,465,657 (GRCm39) missense probably benign
R8036:Or8w1 UTSW 2 87,465,847 (GRCm39) missense probably benign 0.36
R8158:Or8w1 UTSW 2 87,465,233 (GRCm39) missense probably damaging 1.00
R9026:Or8w1 UTSW 2 87,465,369 (GRCm39) missense probably damaging 1.00
R9136:Or8w1 UTSW 2 87,465,341 (GRCm39) missense probably benign 0.32
R9428:Or8w1 UTSW 2 87,465,774 (GRCm39) missense probably benign
Predicted Primers
Posted On 2015-02-04