Incidental Mutation 'R1235:Olfr1132'
ID262460
Institutional Source Beutler Lab
Gene Symbol Olfr1132
Ensembl Gene ENSMUSG00000068818
Gene Nameolfactory receptor 1132
SynonymsMOR177-1, GA_x6K02T2Q125-49140947-49140021
MMRRC Submission 039303-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.092) question?
Stock #R1235 (G1)
Quality Score225
Status Not validated
Chromosome2
Chromosomal Location87632583-87637535 bp(-) (GRCm38)
Type of Mutationsplice site (4 bp from exon)
DNA Base Change (assembly) T to G at 87634815 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000088213 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090711] [ENSMUST00000213302] [ENSMUST00000216082] [ENSMUST00000216756]
Predicted Effect probably null
Transcript: ENSMUST00000090711
SMART Domains Protein: ENSMUSP00000088213
Gene: ENSMUSG00000068818

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.3e-45 PFAM
Pfam:7tm_1 41 290 4.8e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213302
Predicted Effect probably benign
Transcript: ENSMUST00000216082
Predicted Effect probably benign
Transcript: ENSMUST00000216756
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.3%
  • 20x: 89.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 18 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arsg T C 11: 109,534,107 probably null Het
Col6a1 C A 10: 76,712,324 A633S unknown Het
Dnajb3 C T 1: 88,205,479 R67H probably benign Het
Fam53c T A 18: 34,768,258 L76Q probably damaging Het
Gys2 A T 6: 142,430,293 Y548N probably damaging Het
Kcnh3 T A 15: 99,242,103 probably null Het
Lrp2 C T 2: 69,524,036 V483I probably damaging Het
Myom3 A T 4: 135,789,543 Y808F probably benign Het
Nmur1 C T 1: 86,386,693 G307S probably damaging Het
Pcdhb13 T C 18: 37,444,959 *797Q probably null Het
Plcb4 G A 2: 135,972,948 G719R probably damaging Het
Pld1 A T 3: 28,028,734 T143S probably benign Het
Rem1 G A 2: 152,634,535 V238M probably damaging Het
Sema5a A T 15: 32,609,226 Y426F probably benign Het
Trpc7 G T 13: 56,887,539 H194N probably damaging Het
Vmn2r106 A T 17: 20,279,479 F165I probably benign Het
Zdbf2 A G 1: 63,309,073 T2204A possibly damaging Het
Zp2 A T 7: 120,138,343 F240I possibly damaging Het
Other mutations in Olfr1132
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01115:Olfr1132 APN 2 87635384 missense probably damaging 1.00
IGL01780:Olfr1132 APN 2 87635080 missense possibly damaging 0.56
R1471:Olfr1132 UTSW 2 87635670 missense probably benign
R2106:Olfr1132 UTSW 2 87635159 missense probably benign 0.22
R3711:Olfr1132 UTSW 2 87635681 missense probably benign
R4024:Olfr1132 UTSW 2 87635155 missense probably damaging 0.97
R4522:Olfr1132 UTSW 2 87635151 missense probably benign
R6531:Olfr1132 UTSW 2 87635529 missense probably damaging 1.00
R7768:Olfr1132 UTSW 2 87635313 missense probably benign
R8036:Olfr1132 UTSW 2 87635503 missense probably benign 0.36
R8158:Olfr1132 UTSW 2 87634889 missense probably damaging 1.00
Predicted Primers
Posted On2015-02-04