Incidental Mutation 'ANU05:Dusp19'
ID 262470
Institutional Source Beutler Lab
Gene Symbol Dusp19
Ensembl Gene ENSMUSG00000027001
Gene Name dual specificity phosphatase 19
Synonyms C79103, TS-DSP1, SKRP1, 5930436K22Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.163) question?
Stock # ANU05
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 80447558-80462005 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 80454618 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 113 (T113A)
Ref Sequence ENSEMBL: ENSMUSP00000028384 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028384]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000028384
AA Change: T113A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000028384
Gene: ENSMUSG00000027001
AA Change: T113A

DomainStartEndE-ValueType
DSPc 64 202 7.6e-36 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125033
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135305
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147290
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148084
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151204
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196622
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.5%
  • 20x: 93.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110038F14Rik G A 15: 76,834,475 (GRCm39) V124I probably damaging Het
Acaca A G 11: 84,206,678 (GRCm39) K1513E probably damaging Het
Acacb T A 5: 114,363,931 (GRCm39) F1464Y probably benign Het
Adgrg6 G A 10: 14,286,274 (GRCm39) A1114V possibly damaging Het
Agl A G 3: 116,566,438 (GRCm39) I975T possibly damaging Het
Akap7 T C 10: 25,147,451 (GRCm39) H93R probably damaging Het
Arhgef11 T C 3: 87,640,481 (GRCm39) W1213R probably benign Het
Ccar1 T A 10: 62,592,428 (GRCm39) E708V probably damaging Het
Cfap206 C T 4: 34,721,562 (GRCm39) S162N probably damaging Het
Cilp T C 9: 65,186,265 (GRCm39) S787P possibly damaging Het
Col6a3 G A 1: 90,730,014 (GRCm39) T1157I probably damaging Het
D630003M21Rik T C 2: 158,038,308 (GRCm39) Y1046C probably benign Het
Dock3 A G 9: 106,772,862 (GRCm39) S464P probably benign Het
Dync1h1 A C 12: 110,615,538 (GRCm39) Y2957S probably benign Het
Epdr1 T C 13: 19,778,814 (GRCm39) Y94C probably damaging Het
Fcho1 A T 8: 72,165,191 (GRCm39) L422Q probably benign Het
Gca T A 2: 62,520,787 (GRCm39) Y210* probably null Het
Gpnmb T C 6: 49,032,615 (GRCm39) V513A probably benign Het
Irx4 A G 13: 73,415,786 (GRCm39) T192A probably damaging Het
Isca1 T C 13: 59,906,785 (GRCm39) T54A probably benign Het
Kif12 GGGGC GGGGCCTCCACCCGGCGGGC 4: 63,089,660 (GRCm39) probably benign Het
L3mbtl1 T C 2: 162,812,100 (GRCm39) V715A probably benign Het
Lama1 G A 17: 68,045,865 (GRCm39) D257N probably damaging Het
Lgr5 T C 10: 115,314,439 (GRCm39) H166R probably damaging Het
M6pr A G 6: 122,289,218 (GRCm39) R9G probably benign Het
Nmt2 T G 2: 3,315,731 (GRCm39) S240R probably benign Het
Npas3 A G 12: 54,114,857 (GRCm39) E593G possibly damaging Het
Or8k30 G A 2: 86,339,513 (GRCm39) A237T possibly damaging Het
Pank4 T C 4: 155,059,103 (GRCm39) M412T probably damaging Het
Psd A G 19: 46,303,186 (GRCm39) V100A possibly damaging Het
Rab11fip3 T C 17: 26,235,087 (GRCm39) T28A probably damaging Het
Rnpepl1 A T 1: 92,847,468 (GRCm39) D685V probably benign Het
Rrad T C 8: 105,357,283 (GRCm39) E88G probably benign Het
Sdk2 T A 11: 113,733,906 (GRCm39) M846L probably benign Het
Sparcl1 A T 5: 104,242,581 (GRCm39) V36E possibly damaging Het
Spmip5 A T 19: 58,777,545 (GRCm39) H80Q probably damaging Het
Srrm4 C T 5: 116,605,628 (GRCm39) E210K unknown Het
Stk25 A T 1: 93,551,145 (GRCm39) probably null Het
Tacr3 A T 3: 134,635,810 (GRCm39) Y338F probably damaging Het
Tap2 A T 17: 34,428,184 (GRCm39) Q286L probably benign Het
Tedc1 C T 12: 113,126,808 (GRCm39) R357* probably null Het
Tubgcp5 C A 7: 55,458,277 (GRCm39) A396E possibly damaging Het
Ube2o T C 11: 116,430,960 (GRCm39) D980G probably damaging Het
Vmn1r86 T C 7: 12,836,433 (GRCm39) M98V probably benign Het
Vmn2r58 T A 7: 41,513,935 (GRCm39) H236L probably benign Het
Zfp521 T C 18: 13,950,303 (GRCm39) H1217R probably damaging Het
Zfyve1 A T 12: 83,601,779 (GRCm39) F110I probably benign Het
Other mutations in Dusp19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00329:Dusp19 APN 2 80,461,269 (GRCm39) missense probably damaging 0.97
IGL00584:Dusp19 APN 2 80,461,126 (GRCm39) splice site probably null
IGL01291:Dusp19 APN 2 80,454,618 (GRCm39) missense probably benign 0.01
IGL01592:Dusp19 APN 2 80,447,825 (GRCm39) missense probably damaging 1.00
IGL02808:Dusp19 APN 2 80,447,815 (GRCm39) missense probably benign 0.04
IGL03002:Dusp19 APN 2 80,461,279 (GRCm39) missense probably damaging 1.00
P0033:Dusp19 UTSW 2 80,447,729 (GRCm39) start codon destroyed probably null 1.00
R4815:Dusp19 UTSW 2 80,461,289 (GRCm39) missense probably benign 0.00
R5715:Dusp19 UTSW 2 80,461,330 (GRCm39) missense probably benign 0.43
R7693:Dusp19 UTSW 2 80,447,905 (GRCm39) missense probably benign 0.00
R8073:Dusp19 UTSW 2 80,447,828 (GRCm39) missense probably benign 0.01
R8322:Dusp19 UTSW 2 80,454,635 (GRCm39) missense probably damaging 1.00
R8817:Dusp19 UTSW 2 80,454,631 (GRCm39) missense probably damaging 1.00
R8998:Dusp19 UTSW 2 80,461,271 (GRCm39) missense probably benign 0.03
R8999:Dusp19 UTSW 2 80,461,271 (GRCm39) missense probably benign 0.03
R9109:Dusp19 UTSW 2 80,447,729 (GRCm39) start codon destroyed probably null 1.00
R9298:Dusp19 UTSW 2 80,447,729 (GRCm39) start codon destroyed probably null 1.00
R9318:Dusp19 UTSW 2 80,461,344 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- GGCCAGCATCAGTAAGCAGTTCTC -3'
(R):5'- TTGCAAAATGTACAAAGACTGGGCG -3'

Sequencing Primer
(F):5'- GCTTGTGATAGTAAGTTCACCC -3'
(R):5'- CGGTGGTCCTATGTTTTTGAATTTC -3'
Posted On 2015-02-04