Mutagenetix > Incidental Mutation

Incidental Mutation 'ANU05:Vmn2r58'

262489

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r58

Ensembl Gene

ENSMUSG00000090383

Gene Name

vomeronasal 2, receptor 58

Synonyms

EG628422

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.377) question?

Stock #

ANU05

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

41486305-41522094 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 41513935 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Leucine at position 236 (H236L)

Ref Sequence

ENSEMBL: ENSMUSP00000126966 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171671]

AlphaFold

K7N6V2

Predicted Effect

probably benign
Transcript: ENSMUST00000171671
AA Change: H236L

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000126966
Gene: ENSMUSG00000090383
AA Change: H236L

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	471	8e-43	PFAM
Pfam:NCD3G	514	567	1.8e-23	PFAM
Pfam:7tm_3	597	835	2.9e-52	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.5%
20x: 93.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110038F14Rik	G	A	15: 76,834,475 (GRCm39)	V124I	probably damaging	Het
Acaca	A	G	11: 84,206,678 (GRCm39)	K1513E	probably damaging	Het
Acacb	T	A	5: 114,363,931 (GRCm39)	F1464Y	probably benign	Het
Adgrg6	G	A	10: 14,286,274 (GRCm39)	A1114V	possibly damaging	Het
Agl	A	G	3: 116,566,438 (GRCm39)	I975T	possibly damaging	Het
Akap7	T	C	10: 25,147,451 (GRCm39)	H93R	probably damaging	Het
Arhgef11	T	C	3: 87,640,481 (GRCm39)	W1213R	probably benign	Het
Ccar1	T	A	10: 62,592,428 (GRCm39)	E708V	probably damaging	Het
Cfap206	C	T	4: 34,721,562 (GRCm39)	S162N	probably damaging	Het
Cilp	T	C	9: 65,186,265 (GRCm39)	S787P	possibly damaging	Het
Col6a3	G	A	1: 90,730,014 (GRCm39)	T1157I	probably damaging	Het
D630003M21Rik	T	C	2: 158,038,308 (GRCm39)	Y1046C	probably benign	Het
Dock3	A	G	9: 106,772,862 (GRCm39)	S464P	probably benign	Het
Dusp19	A	G	2: 80,454,618 (GRCm39)	T113A	probably benign	Het
Dync1h1	A	C	12: 110,615,538 (GRCm39)	Y2957S	probably benign	Het
Epdr1	T	C	13: 19,778,814 (GRCm39)	Y94C	probably damaging	Het
Fcho1	A	T	8: 72,165,191 (GRCm39)	L422Q	probably benign	Het
Gca	T	A	2: 62,520,787 (GRCm39)	Y210*	probably null	Het
Gpnmb	T	C	6: 49,032,615 (GRCm39)	V513A	probably benign	Het
Irx4	A	G	13: 73,415,786 (GRCm39)	T192A	probably damaging	Het
Isca1	T	C	13: 59,906,785 (GRCm39)	T54A	probably benign	Het
Kif12	GGGGC	GGGGCCTCCACCCGGCGGGC	4: 63,089,660 (GRCm39)		probably benign	Het
L3mbtl1	T	C	2: 162,812,100 (GRCm39)	V715A	probably benign	Het
Lama1	G	A	17: 68,045,865 (GRCm39)	D257N	probably damaging	Het
Lgr5	T	C	10: 115,314,439 (GRCm39)	H166R	probably damaging	Het
M6pr	A	G	6: 122,289,218 (GRCm39)	R9G	probably benign	Het
Nmt2	T	G	2: 3,315,731 (GRCm39)	S240R	probably benign	Het
Npas3	A	G	12: 54,114,857 (GRCm39)	E593G	possibly damaging	Het
Or8k30	G	A	2: 86,339,513 (GRCm39)	A237T	possibly damaging	Het
Pank4	T	C	4: 155,059,103 (GRCm39)	M412T	probably damaging	Het
Psd	A	G	19: 46,303,186 (GRCm39)	V100A	possibly damaging	Het
Rab11fip3	T	C	17: 26,235,087 (GRCm39)	T28A	probably damaging	Het
Rnpepl1	A	T	1: 92,847,468 (GRCm39)	D685V	probably benign	Het
Rrad	T	C	8: 105,357,283 (GRCm39)	E88G	probably benign	Het
Sdk2	T	A	11: 113,733,906 (GRCm39)	M846L	probably benign	Het
Sparcl1	A	T	5: 104,242,581 (GRCm39)	V36E	possibly damaging	Het
Spmip5	A	T	19: 58,777,545 (GRCm39)	H80Q	probably damaging	Het
Srrm4	C	T	5: 116,605,628 (GRCm39)	E210K	unknown	Het
Stk25	A	T	1: 93,551,145 (GRCm39)		probably null	Het
Tacr3	A	T	3: 134,635,810 (GRCm39)	Y338F	probably damaging	Het
Tap2	A	T	17: 34,428,184 (GRCm39)	Q286L	probably benign	Het
Tedc1	C	T	12: 113,126,808 (GRCm39)	R357*	probably null	Het
Tubgcp5	C	A	7: 55,458,277 (GRCm39)	A396E	possibly damaging	Het
Ube2o	T	C	11: 116,430,960 (GRCm39)	D980G	probably damaging	Het
Vmn1r86	T	C	7: 12,836,433 (GRCm39)	M98V	probably benign	Het
Zfp521	T	C	18: 13,950,303 (GRCm39)	H1217R	probably damaging	Het
Zfyve1	A	T	12: 83,601,779 (GRCm39)	F110I	probably benign	Het

Other mutations in Vmn2r58

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00089:Vmn2r58	APN	7	41,513,854 (GRCm39)	missense	possibly damaging	0.53
IGL00924:Vmn2r58	APN	7	41,486,891 (GRCm39)	missense	probably damaging	1.00
IGL01291:Vmn2r58	APN	7	41,513,935 (GRCm39)	missense	probably benign	0.02
IGL01480:Vmn2r58	APN	7	41,514,116 (GRCm39)	missense	probably benign	0.01
IGL01551:Vmn2r58	APN	7	41,514,703 (GRCm39)	missense	probably damaging	0.97
IGL01591:Vmn2r58	APN	7	41,514,753 (GRCm39)	missense	probably benign	0.03
IGL01940:Vmn2r58	APN	7	41,487,071 (GRCm39)	missense	probably benign	0.00
IGL01994:Vmn2r58	APN	7	41,486,394 (GRCm39)	missense	probably damaging	0.98
IGL02041:Vmn2r58	APN	7	41,514,703 (GRCm39)	missense	probably damaging	0.97
IGL02222:Vmn2r58	APN	7	41,513,449 (GRCm39)	missense	possibly damaging	0.81
IGL02317:Vmn2r58	APN	7	41,486,765 (GRCm39)	missense	possibly damaging	0.89
IGL02614:Vmn2r58	APN	7	41,486,553 (GRCm39)	missense	probably damaging	1.00
IGL02673:Vmn2r58	APN	7	41,514,082 (GRCm39)	missense	possibly damaging	0.90
IGL03323:Vmn2r58	APN	7	41,511,295 (GRCm39)	missense	probably benign	0.06
IGL03337:Vmn2r58	APN	7	41,513,810 (GRCm39)	missense	possibly damaging	0.93
IGL03380:Vmn2r58	APN	7	41,513,874 (GRCm39)	missense	probably benign	0.00
R0138:Vmn2r58	UTSW	7	41,487,048 (GRCm39)	missense	probably damaging	1.00
R0141:Vmn2r58	UTSW	7	41,511,309 (GRCm39)	missense	probably benign	0.11
R0421:Vmn2r58	UTSW	7	41,514,628 (GRCm39)	missense	probably benign	0.02
R0604:Vmn2r58	UTSW	7	41,510,000 (GRCm39)	missense	possibly damaging	0.78
R0854:Vmn2r58	UTSW	7	41,486,562 (GRCm39)	missense	probably damaging	1.00
R1413:Vmn2r58	UTSW	7	41,513,387 (GRCm39)	missense	probably benign	0.01
R1441:Vmn2r58	UTSW	7	41,486,864 (GRCm39)	missense	probably damaging	1.00
R1678:Vmn2r58	UTSW	7	41,513,480 (GRCm39)	missense	probably benign	0.40
R1691:Vmn2r58	UTSW	7	41,486,913 (GRCm39)	missense	possibly damaging	0.95
R1699:Vmn2r58	UTSW	7	41,509,951 (GRCm39)	missense	probably benign
R1865:Vmn2r58	UTSW	7	41,486,682 (GRCm39)	missense	possibly damaging	0.95
R2008:Vmn2r58	UTSW	7	41,509,924 (GRCm39)	missense	probably damaging	1.00
R2036:Vmn2r58	UTSW	7	41,513,417 (GRCm39)	missense	probably benign
R2202:Vmn2r58	UTSW	7	41,513,594 (GRCm39)	missense	probably benign	0.07
R3787:Vmn2r58	UTSW	7	41,513,498 (GRCm39)	missense	probably benign	0.01
R3883:Vmn2r58	UTSW	7	41,513,914 (GRCm39)	nonsense	probably null
R3944:Vmn2r58	UTSW	7	41,513,885 (GRCm39)	missense	probably benign	0.03
R3949:Vmn2r58	UTSW	7	41,513,348 (GRCm39)	missense	probably benign	0.08
R4232:Vmn2r58	UTSW	7	41,487,011 (GRCm39)	missense	possibly damaging	0.91
R4409:Vmn2r58	UTSW	7	41,522,051 (GRCm39)	missense	possibly damaging	0.69
R4411:Vmn2r58	UTSW	7	41,511,360 (GRCm39)	missense	possibly damaging	0.85
R4413:Vmn2r58	UTSW	7	41,511,360 (GRCm39)	missense	possibly damaging	0.85
R4600:Vmn2r58	UTSW	7	41,522,046 (GRCm39)	missense	probably benign	0.03
R4610:Vmn2r58	UTSW	7	41,487,117 (GRCm39)	missense	probably benign
R4646:Vmn2r58	UTSW	7	41,509,935 (GRCm39)	missense	probably damaging	0.96
R4793:Vmn2r58	UTSW	7	41,514,495 (GRCm39)	missense	probably damaging	0.99
R4870:Vmn2r58	UTSW	7	41,486,639 (GRCm39)	missense	possibly damaging	0.76
R4981:Vmn2r58	UTSW	7	41,486,885 (GRCm39)	missense	probably damaging	1.00
R4993:Vmn2r58	UTSW	7	41,487,176 (GRCm39)	missense	probably benign	0.00
R5024:Vmn2r58	UTSW	7	41,513,746 (GRCm39)	missense	probably damaging	0.99
R5064:Vmn2r58	UTSW	7	41,486,534 (GRCm39)	missense	probably damaging	0.99
R5330:Vmn2r58	UTSW	7	41,513,384 (GRCm39)	nonsense	probably null
R5526:Vmn2r58	UTSW	7	41,522,069 (GRCm39)	missense	probably benign	0.01
R5980:Vmn2r58	UTSW	7	41,514,480 (GRCm39)	missense	possibly damaging	0.81
R6163:Vmn2r58	UTSW	7	41,486,825 (GRCm39)	missense	probably benign	0.31
R6365:Vmn2r58	UTSW	7	41,513,607 (GRCm39)	missense	probably benign	0.42
R6567:Vmn2r58	UTSW	7	41,514,673 (GRCm39)	missense	probably benign	0.34
R6594:Vmn2r58	UTSW	7	41,486,535 (GRCm39)	missense	possibly damaging	0.69
R6980:Vmn2r58	UTSW	7	41,513,662 (GRCm39)	missense	possibly damaging	0.64
R7373:Vmn2r58	UTSW	7	41,487,212 (GRCm39)	missense	probably damaging	1.00
R7458:Vmn2r58	UTSW	7	41,487,123 (GRCm39)	missense	probably benign	0.06
R7630:Vmn2r58	UTSW	7	41,513,611 (GRCm39)	missense	probably damaging	0.99
R7807:Vmn2r58	UTSW	7	41,521,910 (GRCm39)	missense	probably benign	0.05
R8114:Vmn2r58	UTSW	7	41,511,392 (GRCm39)	missense	probably damaging	1.00
R8232:Vmn2r58	UTSW	7	41,514,076 (GRCm39)	missense	probably damaging	0.97
R8313:Vmn2r58	UTSW	7	41,521,952 (GRCm39)	missense	probably benign	0.01
R8412:Vmn2r58	UTSW	7	41,513,722 (GRCm39)	missense	probably benign	0.01
R8530:Vmn2r58	UTSW	7	41,513,576 (GRCm39)	missense	probably damaging	1.00
R8851:Vmn2r58	UTSW	7	41,487,219 (GRCm39)	missense	probably benign
R8881:Vmn2r58	UTSW	7	41,486,609 (GRCm39)	missense	probably benign	0.05
R8936:Vmn2r58	UTSW	7	41,513,981 (GRCm39)	missense
R9045:Vmn2r58	UTSW	7	41,487,087 (GRCm39)	missense	probably benign	0.00
R9166:Vmn2r58	UTSW	7	41,513,431 (GRCm39)	missense	probably damaging	1.00
R9706:Vmn2r58	UTSW	7	41,510,000 (GRCm39)	missense	probably damaging	0.99
RF006:Vmn2r58	UTSW	7	41,486,383 (GRCm39)	frame shift	probably null
RF027:Vmn2r58	UTSW	7	41,486,383 (GRCm39)	frame shift	probably null
Z1176:Vmn2r58	UTSW	7	41,513,789 (GRCm39)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- GCTCAAGACCCAGACTTTCCATGTC -3'
(R):5'- GCATCTGCCCACATTGGAACATTTC -3'

Sequencing Primer
(F):5'- CAGACTTTCCATGTCACTAACAG -3'
(R):5'- CTATCTTGAATGACCGAGGTCAG -3'

Posted On

2015-02-04