Mutagenetix > Incidental Mutations

Incidental Mutation 'R0211:Adgrf1'

26254

Institutional Source

Beutler Lab

Gene Symbol

Adgrf1

Ensembl Gene

ENSMUSG00000041293

Gene Name

adhesion G protein-coupled receptor F1

Synonyms

Gpr110, 5031409J19Rik

MMRRC Submission

038462-MU

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0211 (G1)

Quality Score

177

Status

Not validated

Chromosome

Chromosomal Location

43270329-43324737 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 43296690 bp

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 100 (L100P)

Ref Sequence

ENSEMBL: ENSMUSP00000049380 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000047399]

Predicted Effect

probably damaging
Transcript: ENSMUST00000047399
AA Change: L100P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000049380
Gene: ENSMUSG00000041293
AA Change: L100P

Domain	Start	End	E-Value	Type
signal peptide	1	17	N/A	INTRINSIC
low complexity region	59	83	N/A	INTRINSIC
Pfam:SEA	150	238	3.7e-10	PFAM
low complexity region	341	363	N/A	INTRINSIC
GPS	528	576	5.56e-15	SMART
Pfam:7tm_2	580	832	2.1e-38	PFAM

Coding Region Coverage

1x: 96.9%
3x: 92.1%
10x: 58.4%
20x: 15.8%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a reporter allele exhibit normal viability and fertility. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700049A03Rik	T	C	12: 71,216,096	L1401P	possibly damaging	Het
Akt1	T	C	12: 112,655,142	T407A	probably damaging	Het
Arnt	T	A	3: 95,476,149	M242K	probably damaging	Het
Atad5	T	G	11: 80,095,647	V520G	probably benign	Het
Cbr2	T	A	11: 120,730,788	I88L	probably benign	Het
Ccdc51	T	C	9: 109,089,373	M10T	probably benign	Het
Cryba1	T	A	11: 77,718,867	Y179F	probably damaging	Het
Dcaf4	T	A	12: 83,535,961	F277I	probably damaging	Het
Ddost	G	A	4: 138,309,602	V159M	probably damaging	Het
Dnase2a	A	G	8: 84,908,788		probably benign	Het
Efcc1	A	T	6: 87,749,154	T312S	probably benign	Het
Ermard	A	T	17: 15,021,943	Q127L	probably damaging	Het
Ggnbp2	G	A	11: 84,840,313	T325M	probably damaging	Het
Gm8909	T	C	17: 36,168,007	T117A	probably damaging	Het
Ift74	C	T	4: 94,679,255	T395I	probably benign	Het
Irf8	A	T	8: 120,739,975	D53V	probably damaging	Het
Itgad	A	G	7: 128,204,641	Y69C	probably damaging	Het
Lpin3	A	T	2: 160,898,681	D382V	probably damaging	Het
Map4k3	C	T	17: 80,644,841	A179T	probably damaging	Het
Nck1	A	T	9: 100,497,767	W144R	probably damaging	Het
Nin	T	G	12: 70,014,875	T2072P	probably damaging	Het
Nop2	T	G	6: 125,141,344	L529R	probably damaging	Het
Nynrin	T	C	14: 55,871,798	F1454S	probably benign	Het
Olfr1062	A	C	2: 86,423,107	S190A	probably damaging	Het
Olfr1328	T	A	4: 118,934,270	M191L	probably benign	Het
Olfr1453	T	C	19: 13,028,282	T16A	possibly damaging	Het
Pcdhb10	A	T	18: 37,414,006	M712L	probably benign	Het
Pcx	C	T	19: 4,620,199	A935V	probably damaging	Het
Pdzd7	A	G	19: 45,033,667	V514A	possibly damaging	Het
Plxnb1	T	A	9: 109,103,663	Y568*	probably null	Het
Rgr	T	G	14: 37,046,968	T37P	probably damaging	Het
Rpusd2	A	G	2: 119,038,412	S439G	probably benign	Het
Slc6a21	A	C	7: 45,288,243	T653P	possibly damaging	Het
Spdef	C	T	17: 27,714,920	R309H	probably damaging	Het
Srp68	A	T	11: 116,265,551	Y84N	probably damaging	Het
Tmem63b	T	A	17: 45,661,913	M652L	probably benign	Het
Tnk1	A	G	11: 69,855,181	V306A	probably damaging	Het
Tnnc2	T	A	2: 164,777,484	I147F	probably damaging	Het
Tyw3	T	C	3: 154,587,495	N181S	probably damaging	Het
Unc79	T	A	12: 103,072,792	S682T	probably benign	Het
Wasl	G	T	6: 24,633,893	A124E	probably damaging	Het
Zfp287	T	C	11: 62,714,917	H388R	probably damaging	Het
Zfp335	T	C	2: 164,907,692	T262A	probably damaging	Het
Zfp457	C	G	13: 67,293,147	G359R	probably benign	Het
Zfp872	T	A	9: 22,200,173	I316N	probably damaging	Het

Other mutations in Adgrf1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01343:Adgrf1	APN	17	43313195	missense	probably null	0.92
IGL01359:Adgrf1	APN	17	43310686	missense	probably damaging	0.99
IGL02131:Adgrf1	APN	17	43303747	missense	probably damaging	0.99
IGL02692:Adgrf1	APN	17	43303778	missense	probably damaging	1.00
IGL02891:Adgrf1	APN	17	43311161	missense	probably damaging	0.96
IGL03027:Adgrf1	APN	17	43296714	missense	probably damaging	1.00
IGL03296:Adgrf1	APN	17	43321153	splice site	probably benign
R0211:Adgrf1	UTSW	17	43296690	missense	probably damaging	1.00
R0389:Adgrf1	UTSW	17	43303788	critical splice donor site	probably null
R0488:Adgrf1	UTSW	17	43310411	missense	probably damaging	0.99
R1591:Adgrf1	UTSW	17	43310981	missense	probably damaging	1.00
R1817:Adgrf1	UTSW	17	43310033	missense	probably benign	0.01
R1819:Adgrf1	UTSW	17	43310033	missense	probably benign	0.01
R2009:Adgrf1	UTSW	17	43321221	nonsense	probably null
R2032:Adgrf1	UTSW	17	43311275	missense	probably damaging	1.00
R2140:Adgrf1	UTSW	17	43300802	missense	probably damaging	0.99
R3953:Adgrf1	UTSW	17	43310207	missense	probably benign	0.08
R4679:Adgrf1	UTSW	17	43310493	missense	probably damaging	1.00
R4775:Adgrf1	UTSW	17	43311163	missense	probably damaging	1.00
R4858:Adgrf1	UTSW	17	43303672	missense	probably damaging	1.00
R4894:Adgrf1	UTSW	17	43299084	nonsense	probably null
R4895:Adgrf1	UTSW	17	43310620	missense	probably benign	0.33
R4935:Adgrf1	UTSW	17	43295239	missense	probably benign	0.00
R5027:Adgrf1	UTSW	17	43303747	missense	probably damaging	0.99
R5373:Adgrf1	UTSW	17	43291005	start gained	probably benign
R5374:Adgrf1	UTSW	17	43291005	start gained	probably benign
R5455:Adgrf1	UTSW	17	43321143	splice site	probably null
R5579:Adgrf1	UTSW	17	43311064	missense	probably damaging	1.00
R5985:Adgrf1	UTSW	17	43293255	missense	probably benign	0.00
R6038:Adgrf1	UTSW	17	43295209	missense	probably benign	0.00
R6038:Adgrf1	UTSW	17	43295209	missense	probably benign	0.00
R6160:Adgrf1	UTSW	17	43310687	missense	probably damaging	1.00
R6227:Adgrf1	UTSW	17	43310273	missense	probably benign	0.05
R6500:Adgrf1	UTSW	17	43310372	missense	probably damaging	1.00
R7066:Adgrf1	UTSW	17	43310260	missense	probably benign	0.05
R7099:Adgrf1	UTSW	17	43310602	missense	probably benign	0.00
R7561:Adgrf1	UTSW	17	43311109	missense	possibly damaging	0.94

Predicted Primers

Posted On

2013-04-16