Incidental Mutation 'ANU18:Ngdn'
ID 262555
Institutional Source Beutler Lab
Gene Symbol Ngdn
Ensembl Gene ENSMUSG00000022204
Gene Name neuroguidin, EIF4E binding protein
Synonyms 1500001L15Rik, Ngd, neuroguidin
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # ANU18
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 55252911-55261594 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 55254571 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Serine at position 41 (A41S)
Ref Sequence ENSEMBL: ENSMUSP00000022815 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022815]
AlphaFold Q9DB96
Predicted Effect probably benign
Transcript: ENSMUST00000022815
AA Change: A41S

PolyPhen 2 Score 0.148 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000022815
Gene: ENSMUSG00000022204
AA Change: A41S

DomainStartEndE-ValueType
Pfam:Sas10_Utp3 18 98 1.3e-18 PFAM
low complexity region 142 170 N/A INTRINSIC
low complexity region 296 314 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226258
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226658
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227833
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1600012H06Rik C T 17: 15,164,181 (GRCm39) probably null Het
Acacb A T 5: 114,384,559 (GRCm39) I2238L probably benign Het
Aldh1l2 T C 10: 83,358,710 (GRCm39) Y95C probably damaging Het
Asxl2 A G 12: 3,551,425 (GRCm39) T1056A probably damaging Het
B4galnt1 A G 10: 127,005,648 (GRCm39) T250A possibly damaging Het
Cela3b A T 4: 137,151,154 (GRCm39) probably null Het
Chst3 T C 10: 60,021,654 (GRCm39) T398A probably damaging Het
Cngb3 A G 4: 19,425,625 (GRCm39) T478A probably damaging Het
Cyp4a10 T C 4: 115,375,652 (GRCm39) L45P probably damaging Het
D630003M21Rik A G 2: 158,059,568 (GRCm39) S111P probably benign Het
Defb21 A G 2: 152,416,671 (GRCm39) E49G possibly damaging Het
Dnajc1 T C 2: 18,313,645 (GRCm39) T159A probably damaging Het
Dnmbp A G 19: 43,890,793 (GRCm39) S325P probably benign Het
Fam91a1 T C 15: 58,314,720 (GRCm39) F534L probably damaging Het
Fermt2 T C 14: 45,702,320 (GRCm39) E488G probably damaging Het
Filip1 T C 9: 79,726,462 (GRCm39) D719G possibly damaging Het
Gad1-ps A G 10: 99,281,013 (GRCm39) noncoding transcript Het
Glra3 C A 8: 56,393,997 (GRCm39) A36E probably benign Het
Hnrnpm C T 17: 33,888,142 (GRCm39) probably null Het
Lct T A 1: 128,235,784 (GRCm39) R408* probably null Het
Lrrk2 T A 15: 91,651,542 (GRCm39) Y1733N probably damaging Het
Mindy1 T C 3: 95,195,701 (GRCm39) L148P probably damaging Het
Mkrn2 C A 6: 115,588,750 (GRCm39) Y164* probably null Het
Msra T C 14: 64,447,884 (GRCm39) Y135C probably damaging Het
Ndst3 C T 3: 123,342,565 (GRCm39) A749T probably damaging Het
Nlrp12 A T 7: 3,288,722 (GRCm39) S597T probably damaging Het
Or5b99 A T 19: 12,976,781 (GRCm39) I144F probably damaging Het
Pabpc6 A G 17: 9,886,899 (GRCm39) S551P probably benign Het
Plekhg5 C T 4: 152,197,010 (GRCm39) A752V probably benign Het
Prpf4b T C 13: 35,068,274 (GRCm39) S368P probably benign Het
Pus7 A G 5: 23,951,422 (GRCm39) probably null Het
Rab40b C G 11: 121,248,788 (GRCm39) V156L probably benign Het
Slc9a9 T A 9: 94,937,512 (GRCm39) S455T probably benign Het
Tmem26 A T 10: 68,614,436 (GRCm39) N284Y probably damaging Het
Tmem87a T C 2: 120,211,250 (GRCm39) I232V probably benign Het
Trpm2 A G 10: 77,759,818 (GRCm39) L1106P probably damaging Het
Tshz1 A G 18: 84,032,786 (GRCm39) Y541H probably damaging Het
Zfp213 G T 17: 23,780,391 (GRCm39) A43D probably benign Het
Zfp365 A G 10: 67,745,184 (GRCm39) V198A probably damaging Het
Zfp618 G A 4: 63,051,063 (GRCm39) V615M probably damaging Het
Other mutations in Ngdn
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00924:Ngdn APN 14 55,260,626 (GRCm39) missense probably damaging 0.99
IGL01301:Ngdn APN 14 55,254,571 (GRCm39) missense probably benign 0.15
IGL02350:Ngdn APN 14 55,259,393 (GRCm39) missense probably damaging 1.00
IGL02357:Ngdn APN 14 55,259,393 (GRCm39) missense probably damaging 1.00
PIT4651001:Ngdn UTSW 14 55,253,657 (GRCm39) missense probably benign 0.05
R2062:Ngdn UTSW 14 55,259,564 (GRCm39) missense possibly damaging 0.93
R2251:Ngdn UTSW 14 55,260,852 (GRCm39) critical splice donor site probably null
R5167:Ngdn UTSW 14 55,259,656 (GRCm39) nonsense probably null
R5492:Ngdn UTSW 14 55,260,509 (GRCm39) missense probably benign 0.00
R6174:Ngdn UTSW 14 55,259,556 (GRCm39) missense probably benign 0.38
R6712:Ngdn UTSW 14 55,253,645 (GRCm39) missense probably benign 0.18
R7866:Ngdn UTSW 14 55,258,554 (GRCm39) missense probably damaging 1.00
R8303:Ngdn UTSW 14 55,260,602 (GRCm39) missense probably benign 0.01
R9587:Ngdn UTSW 14 55,254,578 (GRCm39) missense probably benign 0.03
R9669:Ngdn UTSW 14 55,259,339 (GRCm39) missense possibly damaging 0.56
R9737:Ngdn UTSW 14 55,259,339 (GRCm39) missense possibly damaging 0.56
X0025:Ngdn UTSW 14 55,259,372 (GRCm39) missense possibly damaging 0.71
Z1177:Ngdn UTSW 14 55,259,401 (GRCm39) missense probably null 1.00
Predicted Primers PCR Primer
(F):5'- GTGGTGTTCAGCAACAGCGTTTC -3'
(R):5'- TGGTCTGCAATTCTTGCCAGACTC -3'

Sequencing Primer
(F):5'- CAGCGTTTCAGATCATTTTTTAGGC -3'
(R):5'- AGGAGGTCCTCCCTCTTCAAG -3'
Posted On 2015-02-04