Incidental Mutation 'ANU22:Adam29'
ID 262586
Institutional Source Beutler Lab
Gene Symbol Adam29
Ensembl Gene ENSMUSG00000046258
Gene Name a disintegrin and metallopeptidase domain 29
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # ANU22
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 56323947-56359983 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 56324879 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 525 (H525L)
Ref Sequence ENSEMBL: ENSMUSP00000054292 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053441]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000053441
AA Change: H525L

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000054292
Gene: ENSMUSG00000046258
AA Change: H525L

DomainStartEndE-ValueType
transmembrane domain 7 29 N/A INTRINSIC
Pfam:Pep_M12B_propep 33 159 1.9e-17 PFAM
Pfam:Reprolysin_4 203 394 3.3e-10 PFAM
Pfam:Reprolysin_5 203 403 6.9e-15 PFAM
Pfam:Reprolysin 205 395 1.5e-48 PFAM
Pfam:Reprolysin_2 226 386 7.4e-11 PFAM
Pfam:Reprolysin_3 228 349 1.4e-11 PFAM
DISIN 412 487 4.26e-37 SMART
ACR 488 624 2.85e-58 SMART
low complexity region 642 651 N/A INTRINSIC
transmembrane domain 683 705 N/A INTRINSIC
low complexity region 713 746 N/A INTRINSIC
Coding Region Coverage
  • 1x: 98.7%
  • 3x: 98.1%
  • 10x: 96.2%
  • 20x: 92.5%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. [provided by RefSeq, May 2016]
Allele List at MGI

All alleles(1) : Targeted, knock-out(1)

Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aco2 A G 15: 81,797,915 (GRCm39) E663G possibly damaging Het
Adamts2 A G 11: 50,628,190 (GRCm39) N297D probably benign Het
Adamts6 T A 13: 104,526,590 (GRCm39) V506E probably damaging Het
Ankfy1 G A 11: 72,655,617 (GRCm39) E1101K probably damaging Het
Arap3 C T 18: 38,124,380 (GRCm39) probably null Het
Asxl3 T A 18: 22,649,503 (GRCm39) H497Q probably benign Het
Caln1 A G 5: 130,698,392 (GRCm39) E96G probably damaging Het
Cdh23 T C 10: 60,148,403 (GRCm39) T2653A probably damaging Het
Cdk5rap2 T A 4: 70,298,472 (GRCm39) I87F possibly damaging Het
Crybg3 T A 16: 59,349,590 (GRCm39) H934L probably damaging Het
Cyp2d22 G A 15: 82,255,869 (GRCm39) T461I probably damaging Het
Dhcr24 T C 4: 106,429,475 (GRCm39) F183L possibly damaging Het
Dusp16 A T 6: 134,695,824 (GRCm39) S336T probably benign Het
F930017D23Rik T G 10: 43,480,371 (GRCm39) noncoding transcript Het
Fasl A G 1: 161,609,407 (GRCm39) V193A probably damaging Het
Fgf5 T C 5: 98,423,175 (GRCm39) Y187H probably damaging Het
Focad C A 4: 88,311,784 (GRCm39) Q1423K probably benign Het
Gabrp T C 11: 33,505,055 (GRCm39) T249A probably damaging Het
Galnt5 A T 2: 57,915,354 (GRCm39) K637* probably null Het
Grm6 A T 11: 50,750,346 (GRCm39) D503V probably benign Het
Hmg20a A T 9: 56,394,934 (GRCm39) D216V probably damaging Het
Lyst C T 13: 13,852,641 (GRCm39) R2214C probably benign Het
Micu2 T A 14: 58,181,082 (GRCm39) D184V probably damaging Het
Nabp2 T A 10: 128,244,631 (GRCm39) I52F probably damaging Het
Nat8f7 A T 6: 85,684,570 (GRCm39) L90* probably null Het
Or2z2 A T 11: 58,346,088 (GRCm39) M229K probably damaging Het
Or4k47 T C 2: 111,451,546 (GRCm39) N291S probably damaging Het
Pphln1 A G 15: 93,386,985 (GRCm39) E273G probably damaging Het
Ppil1 C A 17: 29,482,862 (GRCm39) V14F possibly damaging Het
Ptprd C A 4: 76,018,693 (GRCm39) D694Y probably damaging Het
Relt A T 7: 100,500,905 (GRCm39) L28Q probably damaging Het
Skic8 C A 9: 54,635,470 (GRCm39) V44L probably damaging Het
Sptbn4 G A 7: 27,056,812 (GRCm39) R2525* probably null Het
St8sia5 G A 18: 77,342,358 (GRCm39) G320D probably damaging Het
Taf2 T C 15: 54,911,670 (GRCm39) E582G probably damaging Het
Tas2r116 T A 6: 132,832,406 (GRCm39) N2K probably benign Het
Tedc1 C T 12: 113,126,808 (GRCm39) R357* probably null Het
Tmem168 A T 6: 13,583,045 (GRCm39) V612E probably damaging Het
Unc79 A G 12: 102,968,130 (GRCm39) S119G probably damaging Het
Washc5 T A 15: 59,227,688 (GRCm39) K425* probably null Het
Wtap G T 17: 13,186,782 (GRCm39) T255K probably benign Het
Zfp148 T C 16: 33,277,313 (GRCm39) V134A probably benign Het
Zfp397 C T 18: 24,093,808 (GRCm39) S431L probably damaging Het
Other mutations in Adam29
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01305:Adam29 APN 8 56,324,879 (GRCm39) missense probably benign 0.01
IGL01406:Adam29 APN 8 56,324,874 (GRCm39) missense probably damaging 1.00
IGL01511:Adam29 APN 8 56,324,456 (GRCm39) missense probably damaging 1.00
IGL01869:Adam29 APN 8 56,324,732 (GRCm39) missense probably damaging 0.99
IGL01894:Adam29 APN 8 56,324,865 (GRCm39) missense probably benign 0.00
IGL02023:Adam29 APN 8 56,325,519 (GRCm39) missense probably benign 0.12
IGL02030:Adam29 APN 8 56,325,157 (GRCm39) missense probably benign 0.35
IGL02071:Adam29 APN 8 56,324,589 (GRCm39) missense possibly damaging 0.95
IGL02094:Adam29 APN 8 56,324,480 (GRCm39) missense possibly damaging 0.48
IGL02108:Adam29 APN 8 56,325,346 (GRCm39) missense probably damaging 0.98
IGL02125:Adam29 APN 8 56,324,974 (GRCm39) nonsense probably null
IGL02330:Adam29 APN 8 56,325,398 (GRCm39) missense probably benign 0.02
IGL02332:Adam29 APN 8 56,324,775 (GRCm39) missense probably damaging 1.00
IGL02548:Adam29 APN 8 56,325,902 (GRCm39) nonsense probably null
IGL02960:Adam29 APN 8 56,325,701 (GRCm39) nonsense probably null
IGL03030:Adam29 APN 8 56,326,100 (GRCm39) missense probably damaging 1.00
D4043:Adam29 UTSW 8 56,325,496 (GRCm39) nonsense probably null
IGL02835:Adam29 UTSW 8 56,326,173 (GRCm39) missense probably damaging 1.00
R0294:Adam29 UTSW 8 56,326,311 (GRCm39) missense probably benign 0.25
R0449:Adam29 UTSW 8 56,325,716 (GRCm39) missense probably benign 0.01
R0607:Adam29 UTSW 8 56,326,310 (GRCm39) missense probably damaging 1.00
R0626:Adam29 UTSW 8 56,324,612 (GRCm39) missense probably benign 0.24
R1296:Adam29 UTSW 8 56,324,754 (GRCm39) nonsense probably null
R1752:Adam29 UTSW 8 56,325,309 (GRCm39) missense probably damaging 0.98
R1930:Adam29 UTSW 8 56,326,124 (GRCm39) missense probably damaging 1.00
R1931:Adam29 UTSW 8 56,326,124 (GRCm39) missense probably damaging 1.00
R2397:Adam29 UTSW 8 56,325,933 (GRCm39) missense probably benign 0.04
R2764:Adam29 UTSW 8 56,324,791 (GRCm39) missense probably damaging 1.00
R4052:Adam29 UTSW 8 56,325,317 (GRCm39) missense probably damaging 1.00
R4978:Adam29 UTSW 8 56,324,436 (GRCm39) missense probably damaging 0.98
R5306:Adam29 UTSW 8 56,324,792 (GRCm39) missense probably damaging 1.00
R6383:Adam29 UTSW 8 56,324,543 (GRCm39) missense probably damaging 0.99
R6528:Adam29 UTSW 8 56,325,596 (GRCm39) missense possibly damaging 0.93
R6579:Adam29 UTSW 8 56,325,779 (GRCm39) missense probably damaging 1.00
R6707:Adam29 UTSW 8 56,325,135 (GRCm39) missense probably damaging 1.00
R7076:Adam29 UTSW 8 56,324,694 (GRCm39) missense probably damaging 1.00
R7099:Adam29 UTSW 8 56,324,439 (GRCm39) missense probably benign 0.01
R7177:Adam29 UTSW 8 56,325,659 (GRCm39) missense probably benign 0.30
R7320:Adam29 UTSW 8 56,325,749 (GRCm39) missense possibly damaging 0.50
R7420:Adam29 UTSW 8 56,325,933 (GRCm39) missense probably benign 0.04
R7438:Adam29 UTSW 8 56,324,609 (GRCm39) missense probably damaging 0.99
R7476:Adam29 UTSW 8 56,326,230 (GRCm39) missense probably damaging 0.97
R7524:Adam29 UTSW 8 56,325,395 (GRCm39) missense probably damaging 1.00
R8066:Adam29 UTSW 8 56,325,703 (GRCm39) missense probably benign 0.11
R8111:Adam29 UTSW 8 56,324,585 (GRCm39) missense probably benign 0.00
R8221:Adam29 UTSW 8 56,325,463 (GRCm39) missense probably benign 0.02
R8350:Adam29 UTSW 8 56,325,224 (GRCm39) missense possibly damaging 0.89
R8353:Adam29 UTSW 8 56,326,196 (GRCm39) missense possibly damaging 0.82
R8453:Adam29 UTSW 8 56,326,196 (GRCm39) missense possibly damaging 0.82
R8723:Adam29 UTSW 8 56,324,513 (GRCm39) missense probably damaging 1.00
R8752:Adam29 UTSW 8 56,325,328 (GRCm39) nonsense probably null
R8809:Adam29 UTSW 8 56,325,659 (GRCm39) missense probably benign 0.30
R9025:Adam29 UTSW 8 56,325,196 (GRCm39) nonsense probably null
R9388:Adam29 UTSW 8 56,325,285 (GRCm39) missense probably damaging 1.00
R9612:Adam29 UTSW 8 56,325,118 (GRCm39) missense possibly damaging 0.77
X0011:Adam29 UTSW 8 56,326,203 (GRCm39) missense probably benign 0.02
Z1177:Adam29 UTSW 8 56,324,531 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGTAATCAGTGCCCCAGCAAGATAC -3'
(R):5'- GTTGCATGTCAAACTGCACTCTGAG -3'

Sequencing Primer
(F):5'- CCCAGCAAGATACATTTTTGACAAG -3'
(R):5'- AACTGCACTCTGAGTACTGG -3'
Posted On 2015-02-04