Incidental Mutation 'R0294:Mgst2'
ID 26272
Institutional Source Beutler Lab
Gene Symbol Mgst2
Ensembl Gene ENSMUSG00000074604
Gene Name microsomal glutathione S-transferase 2
Synonyms GST2, MGST-II
MMRRC Submission 038511-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.207) question?
Stock # R0294 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 51567781-51590098 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 51589251 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 88 (Y88C)
Ref Sequence ENSEMBL: ENSMUSP00000096705 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099106] [ENSMUST00000118075] [ENSMUST00000121440] [ENSMUST00000159554] [ENSMUST00000161590]
AlphaFold A2RST1
Predicted Effect probably damaging
Transcript: ENSMUST00000099106
AA Change: Y88C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000096705
Gene: ENSMUSG00000074604
AA Change: Y88C

DomainStartEndE-ValueType
Pfam:MAPEG 8 124 8.8e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000118075
SMART Domains Protein: ENSMUSP00000113677
Gene: ENSMUSG00000061143

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
low complexity region 52 68 N/A INTRINSIC
coiled coil region 90 132 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000121440
SMART Domains Protein: ENSMUSP00000112637
Gene: ENSMUSG00000061143

DomainStartEndE-ValueType
low complexity region 5 11 N/A INTRINSIC
low complexity region 12 32 N/A INTRINSIC
low complexity region 44 65 N/A INTRINSIC
MamL-1 67 126 6.54e-30 SMART
low complexity region 436 454 N/A INTRINSIC
coiled coil region 459 502 N/A INTRINSIC
low complexity region 504 515 N/A INTRINSIC
low complexity region 621 647 N/A INTRINSIC
low complexity region 698 714 N/A INTRINSIC
coiled coil region 736 778 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159400
Predicted Effect probably benign
Transcript: ENSMUST00000159554
SMART Domains Protein: ENSMUSP00000141745
Gene: ENSMUSG00000074604

DomainStartEndE-ValueType
Pfam:MAPEG 8 80 3.8e-10 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160753
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161230
Predicted Effect probably damaging
Transcript: ENSMUST00000161590
AA Change: I64M

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000125670
Gene: ENSMUSG00000074604
AA Change: I64M

DomainStartEndE-ValueType
low complexity region 5 16 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161627
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162125
Predicted Effect noncoding transcript
Transcript: ENSMUST00000195423
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]
PHENOTYPE: Mice homozygous for a gene trap allele display resistance to induced ER stress related cell death and mortality. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930527J03Rik ACCC ACC 1: 178,276,503 (GRCm38) noncoding transcript Het
Aadat A G 8: 60,987,642 (GRCm39) E319G possibly damaging Het
Abca13 A G 11: 9,219,122 (GRCm39) probably null Het
Actl7b A T 4: 56,740,848 (GRCm39) L170Q possibly damaging Het
Adam29 C A 8: 56,326,311 (GRCm39) V48L probably benign Het
Aknad1 A G 3: 108,682,508 (GRCm39) Y528C probably damaging Het
Alas1 T A 9: 106,118,455 (GRCm39) K222N probably damaging Het
Aplf A G 6: 87,623,227 (GRCm39) V284A probably benign Het
Atp11a G A 8: 12,877,524 (GRCm39) V317M probably benign Het
Bub3 A G 7: 131,169,953 (GRCm39) E206G possibly damaging Het
Cblb T G 16: 51,956,187 (GRCm39) F263L probably damaging Het
Ces2h T A 8: 105,743,236 (GRCm39) M157K probably benign Het
Cfh A G 1: 140,110,999 (GRCm39) F6L probably benign Het
Chst1 G T 2: 92,443,987 (GRCm39) R153L probably damaging Het
Cimap2 T C 4: 106,470,361 (GRCm39) D232G probably damaging Het
Cntnap5a T A 1: 115,843,046 (GRCm39) N121K probably benign Het
Crybg1 A T 10: 43,862,372 (GRCm39) S1467R probably damaging Het
Cyp2d22 A G 15: 82,258,646 (GRCm39) F72L possibly damaging Het
Dmrt2 C T 19: 25,655,435 (GRCm39) P345S probably damaging Het
Dock8 T C 19: 25,165,714 (GRCm39) I1866T probably damaging Het
Egfem1 A G 3: 29,744,270 (GRCm39) N503S probably damaging Het
Ehbp1 T C 11: 22,045,427 (GRCm39) D774G probably benign Het
Foxp2 C A 6: 15,376,773 (GRCm39) probably benign Het
Gins3 T C 8: 96,364,547 (GRCm39) V99A possibly damaging Het
Grm1 A T 10: 10,956,143 (GRCm39) I47N probably damaging Het
H2aj C G 6: 136,785,602 (GRCm39) R89G probably damaging Het
Hsdl2 T A 4: 59,601,408 (GRCm39) S127T probably benign Het
Il5ra A T 6: 106,689,362 (GRCm39) M410K probably benign Het
Ints7 A G 1: 191,344,003 (GRCm39) S548G possibly damaging Het
Kcnt1 A G 2: 25,778,122 (GRCm39) E80G probably damaging Het
Lgr6 A G 1: 134,915,629 (GRCm39) V373A probably damaging Het
Lgr6 T A 1: 135,032,799 (GRCm39) Q27L unknown Het
Map3k14 T C 11: 103,117,963 (GRCm39) I610V possibly damaging Het
Marf1 C T 16: 13,960,398 (GRCm39) A549T probably damaging Het
Metap1d T A 2: 71,352,889 (GRCm39) H239Q probably benign Het
Mroh4 T C 15: 74,477,998 (GRCm39) N903D probably benign Het
Nbeal2 T G 9: 110,461,927 (GRCm39) D1476A probably damaging Het
Nlgn1 C A 3: 26,187,625 (GRCm39) A87S probably benign Het
Nln C T 13: 104,189,087 (GRCm39) G295S probably damaging Het
Nnt T A 13: 119,472,803 (GRCm39) Y719F probably benign Het
Nnt T G 13: 119,474,953 (GRCm39) I659L possibly damaging Het
Or2z8 C T 8: 72,812,244 (GRCm39) T240M probably damaging Het
Or51b17 A T 7: 103,542,137 (GRCm39) H268Q probably benign Het
Or52s6 G A 7: 103,092,291 (GRCm39) T13I possibly damaging Het
Or5p78 A T 7: 108,212,357 (GRCm39) Y281F probably damaging Het
Or9g4 A G 2: 85,505,060 (GRCm39) V145A probably damaging Het
Otogl C T 10: 107,613,089 (GRCm39) C2041Y probably damaging Het
Patj G T 4: 98,385,285 (GRCm39) D300Y probably damaging Het
Pkhd1l1 A T 15: 44,423,831 (GRCm39) E3124D probably benign Het
Plbd2 A G 5: 120,625,514 (GRCm39) probably null Het
Pphln1 T C 15: 93,318,171 (GRCm39) Y57H probably damaging Het
Ppp1r16b C T 2: 158,588,523 (GRCm39) T78M probably damaging Het
Prss40 T G 1: 34,595,162 (GRCm39) D224A possibly damaging Het
Senp6 A G 9: 80,021,007 (GRCm39) probably null Het
Shank3 A G 15: 89,416,301 (GRCm39) E666G probably damaging Het
Slc13a1 T A 6: 24,090,779 (GRCm39) I547F possibly damaging Het
Slc17a3 C T 13: 24,039,841 (GRCm39) S293F probably damaging Het
Slc22a18 G A 7: 143,046,578 (GRCm39) probably null Het
Slc5a4b A G 10: 75,917,161 (GRCm39) C292R probably damaging Het
Spata31e5 T C 1: 28,817,744 (GRCm39) Q96R probably benign Het
Sphkap T A 1: 83,255,966 (GRCm39) E594D possibly damaging Het
Srpra T A 9: 35,126,811 (GRCm39) M61K probably damaging Het
Trmt10c A T 16: 55,855,240 (GRCm39) Y132N possibly damaging Het
Other mutations in Mgst2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00824:Mgst2 APN 3 51,589,999 (GRCm39) missense probably benign 0.00
IGL01712:Mgst2 APN 3 51,571,992 (GRCm39) missense probably damaging 1.00
IGL03401:Mgst2 APN 3 51,571,933 (GRCm39) missense possibly damaging 0.89
R2867:Mgst2 UTSW 3 51,571,954 (GRCm39) synonymous silent
R4394:Mgst2 UTSW 3 51,571,949 (GRCm39) missense probably damaging 1.00
R5149:Mgst2 UTSW 3 51,589,958 (GRCm39) missense probably benign 0.02
R5878:Mgst2 UTSW 3 51,568,651 (GRCm39) utr 5 prime probably benign
R6703:Mgst2 UTSW 3 51,572,033 (GRCm39) critical splice donor site probably null
R7946:Mgst2 UTSW 3 51,584,991 (GRCm39) missense probably damaging 1.00
R9108:Mgst2 UTSW 3 51,589,233 (GRCm39) missense probably damaging 1.00
Z1177:Mgst2 UTSW 3 51,568,691 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCACTAACCAGCAGCTTGAGGACC -3'
(R):5'- GATTAGGAGTCCAAGTGCCTCCAAC -3'

Sequencing Primer
(F):5'- actggcacacttatttatcatactg -3'
(R):5'- ctcaatgaatcccaaacccac -3'
Posted On 2013-04-16