Incidental Mutation 'R1258:Dnajc9'
| ID |
262741 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dnajc9
|
| Ensembl Gene |
ENSMUSG00000021811 |
| Gene Name |
DnaJ heat shock protein family (Hsp40) member C9 |
| Synonyms |
5330419I01Rik |
| MMRRC Submission |
039325-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1258 (G1)
|
| Quality Score |
93 |
|
Status
|
Not validated
|
| Chromosome |
14 |
| Chromosomal Location |
20434706-20438978 bp(-) (GRCm39) |
| Type of Mutation |
splice site (607 bp from exon) |
| DNA Base Change (assembly) |
G to A
at 20438765 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000055619
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000022345]
[ENSMUST00000061444]
|
| AlphaFold |
Q91WN1 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000022345
|
| SMART Domains |
Protein: ENSMUSP00000022345
Gene: ENSMUSG00000021811
| Domain | Start | End | E-Value | Type |
|---|
|
DnaJ
|
14 |
74 |
2.76e-16 |
SMART |
|
coiled coil region
|
176 |
212 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000061444
|
| SMART Domains |
Protein: ENSMUSP00000055619
Gene: ENSMUSG00000049960
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Ribosomal_S16
|
24 |
84 |
9.9e-25 |
PFAM |
|
low complexity region
|
107 |
135 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000223844
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000223889
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000223950
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000224286
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.7%
- 20x: 94.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 18 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam12 |
T |
C |
7: 133,539,176 (GRCm39) |
E112G |
probably damaging |
Het |
| Ccar2 |
T |
C |
14: 70,390,122 (GRCm39) |
N17D |
probably benign |
Het |
| Igsf9 |
G |
A |
1: 172,319,722 (GRCm39) |
R339H |
probably benign |
Het |
| Inpp5a |
G |
T |
7: 139,105,660 (GRCm39) |
G212C |
probably damaging |
Het |
| Itsn2 |
A |
G |
12: 4,723,464 (GRCm39) |
E1133G |
probably damaging |
Het |
| Ltbp1 |
A |
G |
17: 75,532,280 (GRCm39) |
Q118R |
possibly damaging |
Het |
| Pcdhb17 |
A |
T |
18: 37,618,587 (GRCm39) |
I126L |
probably damaging |
Het |
| Qtrt2 |
A |
G |
16: 43,689,446 (GRCm39) |
V184A |
possibly damaging |
Het |
| Rfwd3 |
C |
T |
8: 112,014,874 (GRCm39) |
R326Q |
probably damaging |
Het |
| Sall3 |
G |
A |
18: 81,017,280 (GRCm39) |
A216V |
probably damaging |
Het |
| Shf |
G |
A |
2: 122,199,163 (GRCm39) |
P51S |
probably damaging |
Het |
| St8sia6 |
T |
C |
2: 13,661,695 (GRCm39) |
M379V |
probably benign |
Het |
| Ubr4 |
T |
A |
4: 139,154,225 (GRCm39) |
L2144H |
probably damaging |
Het |
| Ypel1 |
A |
T |
16: 16,923,917 (GRCm39) |
L44H |
probably damaging |
Het |
| Ythdf1 |
C |
A |
2: 180,553,103 (GRCm39) |
A371S |
probably benign |
Het |
| Zdhhc16 |
G |
A |
19: 41,926,483 (GRCm39) |
V89M |
possibly damaging |
Het |
| Zfp37 |
A |
T |
4: 62,110,054 (GRCm39) |
Y375N |
probably damaging |
Het |
| Zmat3 |
A |
T |
3: 32,397,820 (GRCm39) |
N147K |
probably damaging |
Het |
|
| Other mutations in Dnajc9 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00923:Dnajc9
|
APN |
14 |
20,435,515 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01631:Dnajc9
|
APN |
14 |
20,438,176 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1257:Dnajc9
|
UTSW |
14 |
20,438,765 (GRCm39) |
splice site |
probably null |
|
|
R1261:Dnajc9
|
UTSW |
14 |
20,438,765 (GRCm39) |
splice site |
probably null |
|
|
R1765:Dnajc9
|
UTSW |
14 |
20,438,158 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1835:Dnajc9
|
UTSW |
14 |
20,438,402 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7218:Dnajc9
|
UTSW |
14 |
20,438,507 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7570:Dnajc9
|
UTSW |
14 |
20,438,712 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7600:Dnajc9
|
UTSW |
14 |
20,438,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7960:Dnajc9
|
UTSW |
14 |
20,438,764 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9631:Dnajc9
|
UTSW |
14 |
20,438,670 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9722:Dnajc9
|
UTSW |
14 |
20,438,279 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
|
| Posted On |
2015-02-04 |
Incidental Mutation