Mutagenetix > Incidental Mutations

Incidental Mutation 'R1262:Olfr648'

262744

Institutional Source

Beutler Lab

Gene Symbol

Olfr648

Ensembl Gene

ENSMUSG00000042909

Gene Name

olfactory receptor 648

Synonyms

GA_x6K02T2PBJ9-6914780-6913830, MOR31-12

MMRRC Submission

039329-MU

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.465) question?

Stock #

R1262 (G1)

Quality Score

141

Status

Not validated

Chromosome

Chromosomal Location

104177598-104183392 bp(-) (GRCm38)

Type of Mutation

splice site (40 bp from exon)

DNA Base Change (assembly)

A to G at 104179416 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000052659] [ENSMUST00000216612]

AlphaFold

Q8VG19

Predicted Effect

probably null
Transcript: ENSMUST00000052659

SMART Domains

Protein: ENSMUSP00000062529
Gene: ENSMUSG00000042909

Domain	Start	End	E-Value	Type
Pfam:7tm_4	33	312	2e-111	PFAM
Pfam:7TM_GPCR_Srsx	37	309	7.7e-7	PFAM
Pfam:7tm_1	43	294	3.1e-17	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000104877

SMART Domains

Protein: ENSMUSP00000100471
Gene: ENSMUSG00000042909

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	37	309	1.1e-8	PFAM
Pfam:7tm_1	43	294	3.6e-28	PFAM
Pfam:7tm_4	141	287	1.9e-29	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000216612

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.3%
20x: 92.7%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 14 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aak1	T	C	6: 86,935,488	V114A	probably benign	Het
BC048679	A	G	7: 81,495,341	F85L	probably benign	Het
Btbd7	A	G	12: 102,787,951	I852T	probably benign	Het
Cenpk	T	A	13: 104,230,785	V43E	possibly damaging	Het
Chmp7	C	T	14: 69,719,450	M336I	probably benign	Het
Cyp2b10	C	T	7: 25,915,411	T281M	probably benign	Het
Lrriq1	T	C	10: 103,234,137	D6G	possibly damaging	Het
Ltbp1	A	G	17: 75,225,285	Q118R	possibly damaging	Het
Nipsnap3b	G	T	4: 53,015,166	G71V	probably damaging	Het
Olfr623	G	A	7: 103,660,441	P270S	probably benign	Het
Snx25	T	A	8: 46,105,291	R80S	probably damaging	Het
Syt6	A	T	3: 103,585,340		probably null	Het
Tas1r2	G	A	4: 139,655,288	R79Q	probably damaging	Het
Ttc7	C	T	17: 87,340,936	T521I	probably benign	Het

Other mutations in Olfr648

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02121:Olfr648	APN	7	104180225	missense	probably damaging	1.00
IGL02488:Olfr648	APN	7	104180271	missense	possibly damaging	0.66
IGL02956:Olfr648	APN	7	104180127	missense	probably damaging	1.00
R0001:Olfr648	UTSW	7	104179473	nonsense	probably null
R0057:Olfr648	UTSW	7	104180329	missense	probably benign	0.13
R1054:Olfr648	UTSW	7	104180291	missense	probably benign	0.02
R4589:Olfr648	UTSW	7	104179429	splice site	probably null
R4975:Olfr648	UTSW	7	104179529	missense	probably damaging	1.00
R5068:Olfr648	UTSW	7	104180241	missense	probably damaging	1.00
R5643:Olfr648	UTSW	7	104179884	missense	probably benign	0.00
R6195:Olfr648	UTSW	7	104179754	missense	possibly damaging	0.78
R6211:Olfr648	UTSW	7	104179747	nonsense	probably null
R6233:Olfr648	UTSW	7	104179754	missense	possibly damaging	0.78
R6259:Olfr648	UTSW	7	104180054	missense	possibly damaging	0.53
R7138:Olfr648	UTSW	7	104180297	missense	probably damaging	1.00
R7357:Olfr648	UTSW	7	104179771	missense	probably damaging	1.00
R7570:Olfr648	UTSW	7	104179748	missense	probably damaging	1.00
R8352:Olfr648	UTSW	7	104179896	missense	probably damaging	1.00
R8452:Olfr648	UTSW	7	104179896	missense	probably damaging	1.00
R8712:Olfr648	UTSW	7	104179818	missense	probably damaging	1.00
R8937:Olfr648	UTSW	7	104179742	missense	possibly damaging	0.88
X0018:Olfr648	UTSW	7	104179590	missense	probably benign	0.00

Predicted Primers

Posted On

2015-02-04