Incidental Mutation 'R1262:Olfr648'
ID 262744
Institutional Source Beutler Lab
Gene Symbol Olfr648
Ensembl Gene ENSMUSG00000042909
Gene Name olfactory receptor 648
Synonyms GA_x6K02T2PBJ9-6914780-6913830, MOR31-12
MMRRC Submission 039329-MU
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.465) question?
Stock # R1262 (G1)
Quality Score 141
Status Not validated
Chromosome 7
Chromosomal Location 104177598-104183392 bp(-) (GRCm38)
Type of Mutation splice site (40 bp from exon)
DNA Base Change (assembly) A to G at 104179416 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000052659] [ENSMUST00000216612]
AlphaFold Q8VG19
Predicted Effect probably null
Transcript: ENSMUST00000052659
SMART Domains Protein: ENSMUSP00000062529
Gene: ENSMUSG00000042909

DomainStartEndE-ValueType
Pfam:7tm_4 33 312 2e-111 PFAM
Pfam:7TM_GPCR_Srsx 37 309 7.7e-7 PFAM
Pfam:7tm_1 43 294 3.1e-17 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000104877
SMART Domains Protein: ENSMUSP00000100471
Gene: ENSMUSG00000042909

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 37 309 1.1e-8 PFAM
Pfam:7tm_1 43 294 3.6e-28 PFAM
Pfam:7tm_4 141 287 1.9e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216612
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.3%
  • 20x: 92.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 14 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aak1 T C 6: 86,935,488 V114A probably benign Het
BC048679 A G 7: 81,495,341 F85L probably benign Het
Btbd7 A G 12: 102,787,951 I852T probably benign Het
Cenpk T A 13: 104,230,785 V43E possibly damaging Het
Chmp7 C T 14: 69,719,450 M336I probably benign Het
Cyp2b10 C T 7: 25,915,411 T281M probably benign Het
Lrriq1 T C 10: 103,234,137 D6G possibly damaging Het
Ltbp1 A G 17: 75,225,285 Q118R possibly damaging Het
Nipsnap3b G T 4: 53,015,166 G71V probably damaging Het
Olfr623 G A 7: 103,660,441 P270S probably benign Het
Snx25 T A 8: 46,105,291 R80S probably damaging Het
Syt6 A T 3: 103,585,340 probably null Het
Tas1r2 G A 4: 139,655,288 R79Q probably damaging Het
Ttc7 C T 17: 87,340,936 T521I probably benign Het
Other mutations in Olfr648
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02121:Olfr648 APN 7 104180225 missense probably damaging 1.00
IGL02488:Olfr648 APN 7 104180271 missense possibly damaging 0.66
IGL02956:Olfr648 APN 7 104180127 missense probably damaging 1.00
R0001:Olfr648 UTSW 7 104179473 nonsense probably null
R0057:Olfr648 UTSW 7 104180329 missense probably benign 0.13
R1054:Olfr648 UTSW 7 104180291 missense probably benign 0.02
R4589:Olfr648 UTSW 7 104179429 splice site probably null
R4975:Olfr648 UTSW 7 104179529 missense probably damaging 1.00
R5068:Olfr648 UTSW 7 104180241 missense probably damaging 1.00
R5643:Olfr648 UTSW 7 104179884 missense probably benign 0.00
R6195:Olfr648 UTSW 7 104179754 missense possibly damaging 0.78
R6211:Olfr648 UTSW 7 104179747 nonsense probably null
R6233:Olfr648 UTSW 7 104179754 missense possibly damaging 0.78
R6259:Olfr648 UTSW 7 104180054 missense possibly damaging 0.53
R7138:Olfr648 UTSW 7 104180297 missense probably damaging 1.00
R7357:Olfr648 UTSW 7 104179771 missense probably damaging 1.00
R7570:Olfr648 UTSW 7 104179748 missense probably damaging 1.00
R8352:Olfr648 UTSW 7 104179896 missense probably damaging 1.00
R8452:Olfr648 UTSW 7 104179896 missense probably damaging 1.00
R8712:Olfr648 UTSW 7 104179818 missense probably damaging 1.00
R8937:Olfr648 UTSW 7 104179742 missense possibly damaging 0.88
X0018:Olfr648 UTSW 7 104179590 missense probably benign 0.00
Predicted Primers
Posted On 2015-02-04