Incidental Mutation 'R1317:Gm9602'
ID262745
Institutional Source Beutler Lab
Gene Symbol Gm9602
Ensembl Gene ENSMUSG00000090539
Gene Namepredicted gene 9602
Synonyms
MMRRC Submission 039383-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.056) question?
Stock #R1317 (G1)
Quality Score98.2
Status Not validated
Chromosome14
Chromosomal Location4776337-4785002 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 4776499 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Asparagine at position 28 (I28N)
Ref Sequence ENSEMBL: ENSMUSP00000126151 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000163325] [ENSMUST00000177973]
Predicted Effect probably damaging
Transcript: ENSMUST00000163325
AA Change: I28N

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000126151
Gene: ENSMUSG00000090539
AA Change: I28N

DomainStartEndE-ValueType
Pfam:Takusan 48 128 1.9e-26 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000177973
AA Change: I29N

PolyPhen 2 Score 0.734 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000137206
Gene: ENSMUSG00000090539
AA Change: I29N

DomainStartEndE-ValueType
Pfam:Takusan 47 130 1.9e-36 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 98.7%
  • 3x: 97.5%
  • 10x: 93.7%
  • 20x: 84.9%
Validation Efficiency 100% (42/42)
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi3bp C T 16: 56,668,309 H1268Y possibly damaging Het
Afdn A G 17: 13,846,273 T576A probably benign Het
Bcl6 G T 16: 23,977,542 A45D probably damaging Het
Ccdc7b A T 8: 129,136,646 H223L probably benign Het
Cdh15 G C 8: 122,857,495 E112Q probably damaging Het
Cryba2 G T 1: 74,890,676 probably null Het
Depdc1a T C 3: 159,523,287 C559R probably damaging Het
Fam20a A T 11: 109,677,838 N287K probably damaging Het
Gm5519 T C 19: 33,824,991 Y145H possibly damaging Het
Gmeb1 G A 4: 132,234,887 Q154* probably null Het
Gpr156 T C 16: 37,987,567 L192P probably damaging Het
Hnrnpu G A 1: 178,330,257 probably benign Het
Ifi209 A G 1: 173,637,463 D53G possibly damaging Het
Irf6 G A 1: 193,169,301 R400H probably damaging Het
Jag2 T A 12: 112,914,501 M537L probably benign Het
Mid1 A C X: 169,986,094 N215H probably damaging Het
Mt1 T C 8: 94,180,153 probably benign Het
Myo15b C A 11: 115,883,634 P2024Q probably null Het
Nphs1 C T 7: 30,481,831 probably benign Het
Rbm27 G A 18: 42,324,051 probably benign Het
Robo2 A G 16: 74,035,024 V256A probably damaging Het
Rps24 A G 14: 24,491,762 T6A probably damaging Het
Scg3 G A 9: 75,669,340 T251M probably damaging Het
Slc25a23 T C 17: 57,053,888 K179E possibly damaging Het
Smad5 T C 13: 56,736,071 probably benign Het
Tom1 T C 8: 75,051,551 V87A probably benign Het
Trim30b T A 7: 104,357,335 T105S possibly damaging Het
Tspan32 A G 7: 143,017,591 M159V probably benign Het
Tubb1 A G 2: 174,456,896 S124G probably benign Het
Zbtb1 A G 12: 76,386,799 S520G probably benign Het
Zdhhc7 T A 8: 120,084,900 H188L probably benign Het
Other mutations in Gm9602
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02718:Gm9602 APN 14 4776474 nonsense probably null
R3811:Gm9602 UTSW 14 4776499 missense probably damaging 1.00
R7172:Gm9602 UTSW 14 4777282 missense possibly damaging 0.62
R8418:Gm9602 UTSW 14 4779201 splice site probably benign
Predicted Primers
Posted On2015-02-04