Incidental Mutation 'R1298:Cdk18'
ID 262750
Institutional Source Beutler Lab
Gene Symbol Cdk18
Ensembl Gene ENSMUSG00000026437
Gene Name cyclin dependent kinase 18
Synonyms Pctk3
MMRRC Submission 039364-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.227) question?
Stock # R1298 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 132041285-132067433 bp(-) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) A to C at 132050189 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000107981 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027697] [ENSMUST00000112362]
AlphaFold Q04899
Predicted Effect probably benign
Transcript: ENSMUST00000027697
SMART Domains Protein: ENSMUSP00000027697
Gene: ENSMUSG00000026437

DomainStartEndE-ValueType
S_TKc 121 402 1.13e-95 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000112362
SMART Domains Protein: ENSMUSP00000107981
Gene: ENSMUSG00000026437

DomainStartEndE-ValueType
S_TKc 121 402 1.13e-95 SMART
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 94.1%
Validation Efficiency 100% (38/38)
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alox5 A G 6: 116,404,225 (GRCm39) W145R probably damaging Het
Aspm T A 1: 139,385,157 (GRCm39) V267D probably benign Het
Bbs4 A T 9: 59,247,096 (GRCm39) W135R probably damaging Het
Cavin4 T C 4: 48,672,593 (GRCm39) V346A probably benign Het
Cyp2j11 C T 4: 96,195,497 (GRCm39) probably null Het
Dnah6 A T 6: 73,136,118 (GRCm39) I1007K probably damaging Het
Dnmt1 T C 9: 20,852,752 (GRCm39) E118G probably benign Het
Eef2 C CN 10: 81,014,602 (GRCm39) probably null Het
Eif1ad5 T A 12: 87,946,853 (GRCm39) D98E probably benign Het
Gm14496 T C 2: 181,637,885 (GRCm39) F320L probably benign Het
Gsdmc3 A T 15: 63,732,130 (GRCm39) L299M probably damaging Het
H6pd T C 4: 150,066,971 (GRCm39) I472V probably benign Het
Hao2 G T 3: 98,790,985 (GRCm39) T63K possibly damaging Het
Jag2 C T 12: 112,879,939 (GRCm39) probably benign Het
Mapre3 A G 5: 31,022,211 (GRCm39) Y211C probably damaging Het
Mycbp2 A G 14: 103,393,334 (GRCm39) S2966P probably damaging Het
Nsd3 T A 8: 26,169,952 (GRCm39) V696E possibly damaging Het
Obscn A G 11: 58,945,723 (GRCm39) Y4163H possibly damaging Het
Or11h4b A T 14: 50,918,337 (GRCm39) Y251* probably null Het
Or12e8 G A 2: 87,188,414 (GRCm39) A209T probably benign Het
Or6c3 G T 10: 129,308,933 (GRCm39) C124F probably damaging Het
Pde2a A G 7: 101,156,409 (GRCm39) E607G probably benign Het
Pinlyp T A 7: 24,244,391 (GRCm39) D51V probably damaging Het
Rcbtb2 T A 14: 73,399,828 (GRCm39) I87N probably damaging Het
Sfswap A G 5: 129,618,442 (GRCm39) I459V probably benign Het
Slitrk6 T C 14: 110,989,297 (GRCm39) N137D possibly damaging Het
Smg1 A T 7: 117,767,434 (GRCm39) probably benign Het
Sobp T A 10: 42,898,331 (GRCm39) H418L probably damaging Het
Spock1 A C 13: 57,660,563 (GRCm39) D180E probably benign Het
Upk3a G A 15: 84,904,752 (GRCm39) V167I probably benign Het
Vmn1r180 T C 7: 23,652,572 (GRCm39) V245A possibly damaging Het
Zbtb25 T C 12: 76,396,775 (GRCm39) E149G probably benign Het
Zgrf1 T C 3: 127,377,538 (GRCm39) C44R possibly damaging Het
Other mutations in Cdk18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00519:Cdk18 APN 1 132,043,226 (GRCm39) missense probably benign 0.36
IGL00929:Cdk18 APN 1 132,046,257 (GRCm39) critical splice donor site probably null
R0184:Cdk18 UTSW 1 132,046,276 (GRCm39) missense probably benign 0.00
R0606:Cdk18 UTSW 1 132,045,355 (GRCm39) unclassified probably benign
R0624:Cdk18 UTSW 1 132,046,610 (GRCm39) missense probably damaging 1.00
R1295:Cdk18 UTSW 1 132,047,698 (GRCm39) unclassified probably benign
R1296:Cdk18 UTSW 1 132,047,698 (GRCm39) unclassified probably benign
R1611:Cdk18 UTSW 1 132,050,113 (GRCm39) missense probably damaging 1.00
R1959:Cdk18 UTSW 1 132,045,559 (GRCm39) missense possibly damaging 0.95
R2184:Cdk18 UTSW 1 132,043,690 (GRCm39) missense probably damaging 1.00
R2279:Cdk18 UTSW 1 132,043,690 (GRCm39) missense probably damaging 1.00
R2391:Cdk18 UTSW 1 132,043,212 (GRCm39) missense probably benign
R4601:Cdk18 UTSW 1 132,044,657 (GRCm39) missense possibly damaging 0.95
R5001:Cdk18 UTSW 1 132,046,587 (GRCm39) critical splice donor site probably null
R5208:Cdk18 UTSW 1 132,045,218 (GRCm39) critical splice donor site probably null
R5818:Cdk18 UTSW 1 132,046,836 (GRCm39) critical splice donor site probably null
R6282:Cdk18 UTSW 1 132,047,758 (GRCm39) missense probably damaging 1.00
R6546:Cdk18 UTSW 1 132,050,088 (GRCm39) missense probably damaging 0.99
R6644:Cdk18 UTSW 1 132,049,807 (GRCm39) nonsense probably null
R6892:Cdk18 UTSW 1 132,049,848 (GRCm39) missense probably benign 0.01
R6965:Cdk18 UTSW 1 132,045,319 (GRCm39) missense probably damaging 0.98
R7698:Cdk18 UTSW 1 132,050,116 (GRCm39) missense probably damaging 1.00
R7828:Cdk18 UTSW 1 132,044,642 (GRCm39) missense possibly damaging 0.69
R9386:Cdk18 UTSW 1 132,044,183 (GRCm39) critical splice donor site probably null
R9488:Cdk18 UTSW 1 132,049,260 (GRCm39) missense probably benign 0.01
Predicted Primers
Posted On 2015-02-04