Incidental Mutation 'R1415:Zfp787'
ID262758
Institutional Source Beutler Lab
Gene Symbol Zfp787
Ensembl Gene ENSMUSG00000046792
Gene Namezinc finger protein 787
Synonyms
MMRRC Submission 039471-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.135) question?
Stock #R1415 (G1)
Quality Score91
Status Not validated
Chromosome7
Chromosomal Location6131491-6155997 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 6132695 bp
ZygosityHeterozygous
Amino Acid Change Glycine to Cysteine at position 186 (G186C)
Ref Sequence ENSEMBL: ENSMUSP00000092468 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094870] [ENSMUST00000207315]
Predicted Effect probably damaging
Transcript: ENSMUST00000094870
AA Change: G186C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000092468
Gene: ENSMUSG00000046792
AA Change: G186C

DomainStartEndE-ValueType
low complexity region 41 65 N/A INTRINSIC
ZnF_C2H2 66 88 5.67e-5 SMART
ZnF_C2H2 94 116 9.58e-3 SMART
ZnF_C2H2 122 144 1.84e-4 SMART
ZnF_C2H2 150 172 1.3e-4 SMART
ZnF_C2H2 178 200 6.88e-4 SMART
low complexity region 245 277 N/A INTRINSIC
ZnF_C2H2 280 303 2.36e-2 SMART
ZnF_C2H2 317 339 4.72e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000207315
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208973
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.3%
  • 20x: 89.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acacb T C 5: 114,165,921 V135A probably benign Het
Adam21 C T 12: 81,559,547 W480* probably null Het
Ccdc71 T A 9: 108,463,208 Y73* probably null Het
Cfap44 T A 16: 44,481,389 I1830N probably damaging Het
Dnajb11 T C 16: 22,870,621 V264A probably benign Het
Fam135b T C 15: 71,456,928 E1174G probably damaging Het
Fam83e G A 7: 45,726,711 E283K probably damaging Het
Gigyf1 A G 5: 137,519,216 probably null Het
Gm38394 C T 1: 133,657,818 V594M possibly damaging Het
Letm1 A T 5: 33,769,562 N130K probably benign Het
Lrp1b T C 2: 40,629,664 Y137C probably damaging Het
Map3k2 A G 18: 32,228,277 I597V possibly damaging Het
Nek1 A G 8: 61,089,686 E770G probably benign Het
Olfr462 A C 11: 87,889,647 V83G possibly damaging Het
Olfr667 A G 7: 104,916,336 I320T probably benign Het
Pank2 T A 2: 131,282,718 Y68* probably null Het
Prl2c2 G C 13: 13,002,201 T47R probably damaging Het
Secisbp2l C A 2: 125,740,365 G1057V probably benign Het
Slc30a2 C T 4: 134,349,349 T265M probably damaging Het
Smarca2 A G 19: 26,710,684 E1239G probably null Het
Snx30 C T 4: 59,879,261 R167C probably damaging Het
Tmem26 T C 10: 68,778,661 F302S possibly damaging Het
Tpgs2 A G 18: 25,168,553 L19S probably damaging Het
Trp53bp1 T G 2: 121,236,184 E687A probably damaging Het
Ttc27 C T 17: 74,739,672 H243Y probably benign Het
Wdfy4 A T 14: 33,041,180 V2318D possibly damaging Het
Wdr59 G A 8: 111,498,596 P141S probably damaging Het
Other mutations in Zfp787
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02546:Zfp787 APN 7 6132298 missense probably damaging 0.99
IGL02721:Zfp787 APN 7 6132464 unclassified probably null
cheater UTSW 7 6133040 missense possibly damaging 0.93
R0063:Zfp787 UTSW 7 6132323 unclassified probably null
R1434:Zfp787 UTSW 7 6132235 missense probably damaging 0.98
R2042:Zfp787 UTSW 7 6132764 missense possibly damaging 0.72
R5657:Zfp787 UTSW 7 6133054 missense probably damaging 1.00
R5919:Zfp787 UTSW 7 6132835 missense probably damaging 0.98
R6306:Zfp787 UTSW 7 6132361 missense probably damaging 1.00
R7273:Zfp787 UTSW 7 6133040 missense possibly damaging 0.93
R7316:Zfp787 UTSW 7 6155524 unclassified probably benign
R7396:Zfp787 UTSW 7 6132107 makesense probably null
Predicted Primers
Posted On2015-02-04