Incidental Mutation 'R1391:Zfp931'
| ID |
262775 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp931
|
| Ensembl Gene |
ENSMUSG00000078861 |
| Gene Name |
zinc finger protein 931 |
| Synonyms |
2810021G02Rik |
| MMRRC Submission |
039453-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.100)
|
| Stock # |
R1391 (G1)
|
| Quality Score |
80.5 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
177709488-177720269 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 177709984 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 134
(N134S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104552
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000108923]
[ENSMUST00000108924]
[ENSMUST00000131702]
|
| AlphaFold |
A2AHM2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108923
|
| SMART Domains |
Protein: ENSMUSP00000104551
Gene: ENSMUSG00000078861
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
64 |
2.27e-13 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108924
AA Change: N134S
PolyPhen 2
Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000104552
Gene: ENSMUSG00000078861
AA Change: N134S
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
66 |
3.04e-14 |
SMART |
|
ZnF_C2H2
|
78 |
97 |
2.63e2 |
SMART |
|
ZnF_C2H2
|
103 |
125 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
131 |
153 |
8.02e-5 |
SMART |
|
ZnF_C2H2
|
159 |
181 |
2.12e-4 |
SMART |
|
ZnF_C2H2
|
187 |
209 |
1.4e-4 |
SMART |
|
ZnF_C2H2
|
215 |
237 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
243 |
265 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
271 |
293 |
7.49e-5 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000123265
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000131702
|
| Coding Region Coverage |
- 1x: 98.8%
- 3x: 97.7%
- 10x: 94.4%
- 20x: 86.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 20 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Amer3 |
A |
T |
1: 34,627,470 (GRCm39) |
T570S |
probably benign |
Het |
| Ank3 |
A |
T |
10: 69,370,110 (GRCm39) |
K20I |
possibly damaging |
Het |
| Bmp10 |
G |
A |
6: 87,410,740 (GRCm39) |
E178K |
probably benign |
Het |
| Brca1 |
T |
A |
11: 101,417,372 (GRCm39) |
H254L |
possibly damaging |
Het |
| Cdon |
C |
T |
9: 35,415,485 (GRCm39) |
S1241L |
possibly damaging |
Het |
| Cnst |
C |
A |
1: 179,407,051 (GRCm39) |
P33T |
possibly damaging |
Het |
| Dnhd1 |
A |
G |
7: 105,369,331 (GRCm39) |
Y4318C |
probably damaging |
Het |
| Farp1 |
G |
A |
14: 121,495,378 (GRCm39) |
W611* |
probably null |
Het |
| Fst |
C |
T |
13: 114,590,815 (GRCm39) |
|
probably benign |
Het |
| Gapvd1 |
A |
G |
2: 34,596,814 (GRCm39) |
L714P |
probably damaging |
Het |
| Hectd4 |
T |
G |
5: 121,491,758 (GRCm39) |
L3732R |
possibly damaging |
Het |
| Lox |
A |
G |
18: 52,661,891 (GRCm39) |
Y171H |
probably damaging |
Het |
| Magi3 |
T |
A |
3: 103,922,374 (GRCm39) |
K1448* |
probably null |
Het |
| Med12l |
T |
A |
3: 58,945,159 (GRCm39) |
I128N |
probably benign |
Het |
| Pkd1l2 |
T |
C |
8: 117,781,673 (GRCm39) |
T791A |
possibly damaging |
Het |
| Prrt4 |
A |
G |
6: 29,169,950 (GRCm39) |
V834A |
possibly damaging |
Het |
| Ptprz1 |
A |
G |
6: 23,001,728 (GRCm39) |
S1273G |
probably benign |
Het |
| Slc13a4 |
A |
C |
6: 35,248,597 (GRCm39) |
F517V |
probably damaging |
Het |
| Treh |
T |
C |
9: 44,596,602 (GRCm39) |
V452A |
probably benign |
Het |
| Vmn2r83 |
T |
A |
10: 79,314,931 (GRCm39) |
M393K |
probably damaging |
Het |
|
| Other mutations in Zfp931 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02980:Zfp931
|
APN |
2 |
177,711,409 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1907:Zfp931
|
UTSW |
2 |
177,711,684 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2109:Zfp931
|
UTSW |
2 |
177,711,651 (GRCm39) |
missense |
probably null |
1.00 |
|
R2283:Zfp931
|
UTSW |
2 |
177,711,714 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4038:Zfp931
|
UTSW |
2 |
177,709,777 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4039:Zfp931
|
UTSW |
2 |
177,709,777 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4867:Zfp931
|
UTSW |
2 |
177,709,855 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4893:Zfp931
|
UTSW |
2 |
177,709,996 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5593:Zfp931
|
UTSW |
2 |
177,709,595 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7295:Zfp931
|
UTSW |
2 |
177,709,824 (GRCm39) |
nonsense |
probably null |
|
|
R8050:Zfp931
|
UTSW |
2 |
177,709,889 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8069:Zfp931
|
UTSW |
2 |
177,709,709 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8432:Zfp931
|
UTSW |
2 |
177,711,346 (GRCm39) |
makesense |
probably null |
|
|
R8806:Zfp931
|
UTSW |
2 |
177,709,589 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8866:Zfp931
|
UTSW |
2 |
177,710,178 (GRCm39) |
nonsense |
probably null |
|
|
R8987:Zfp931
|
UTSW |
2 |
177,709,592 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8987:Zfp931
|
UTSW |
2 |
177,709,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9088:Zfp931
|
UTSW |
2 |
177,709,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9538:Zfp931
|
UTSW |
2 |
177,709,605 (GRCm39) |
missense |
probably benign |
0.04 |
|
| Predicted Primers |
|
| Posted On |
2015-02-04 |
Incidental Mutation