Mutagenetix > Incidental Mutation

Incidental Mutation 'R3120:Taar7f'

263178

Institutional Source

Beutler Lab

Gene Symbol

Taar7f

Ensembl Gene

ENSMUSG00000100950

Gene Name

trace amine-associated receptor 7F

Synonyms

MMRRC Submission

040593-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

R3120 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

23925408-23926484 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 23925478 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Lysine at position 24 (T24K)

Ref Sequence

ENSEMBL: ENSMUSP00000071611 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071691]

AlphaFold

Q5QD08

Predicted Effect

probably benign
Transcript: ENSMUST00000071691
AA Change: T24K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000071611
Gene: ENSMUSG00000100950
AA Change: T24K

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	56	261	1.6e-7	PFAM
Pfam:7TM_GPCR_Srsx	58	341	2e-10	PFAM
Pfam:7tm_1	64	326	6.6e-58	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000119318

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Bsx	A	G	9: 40,788,908 (GRCm39)	K155R	possibly damaging	Het
Ccdc39	T	C	3: 33,891,987 (GRCm39)	K162E	probably damaging	Het
Crygs	C	T	16: 22,624,301 (GRCm39)	G102D	possibly damaging	Het
Dnah1	G	A	14: 30,988,779 (GRCm39)	R3351*	probably null	Het
Eml1	A	G	12: 108,479,312 (GRCm39)	R362G	probably benign	Het
Fam222b	T	C	11: 78,044,742 (GRCm39)	L101P	probably damaging	Het
Fars2	A	G	13: 36,430,400 (GRCm39)	E276G	probably damaging	Het
Gatad1	G	T	5: 3,691,456 (GRCm39)	Y33*	probably null	Het
Gclc	A	C	9: 77,688,552 (GRCm39)	E219A	possibly damaging	Het
Gm4846	A	G	1: 166,319,117 (GRCm39)	V207A	probably benign	Het
H1f5	A	T	13: 21,964,215 (GRCm39)	S170R	probably benign	Het
Hbq1a	T	C	11: 32,250,472 (GRCm39)	L87P	probably damaging	Het
Magea6	A	T	X: 153,707,291 (GRCm39)	I255N	probably benign	Het
Mfsd12	T	G	10: 81,197,049 (GRCm39)	V206G	probably benign	Het
Mis18bp1	T	C	12: 65,203,762 (GRCm39)		probably null	Het
Nf1	C	A	11: 79,455,725 (GRCm39)	T550K	probably damaging	Het
Nlrp4f	T	C	13: 65,342,530 (GRCm39)	T372A	probably benign	Het
Or5p70	T	C	7: 107,994,930 (GRCm39)	I201T	possibly damaging	Het
Pkdcc	T	C	17: 83,527,466 (GRCm39)	Y215H	probably damaging	Het
Plekha5	A	G	6: 140,537,367 (GRCm39)	T253A	probably benign	Het
Polr2f	T	A	15: 79,028,788 (GRCm39)		probably null	Het
Prph2	C	T	17: 47,234,298 (GRCm39)	A289V	possibly damaging	Het
Ptdss2	C	T	7: 140,732,132 (GRCm39)	H140Y	probably damaging	Het
Rlf	T	A	4: 121,006,680 (GRCm39)	I877L	probably benign	Het
Scgb2b2	T	C	7: 31,003,001 (GRCm39)	L32S	possibly damaging	Het
Sfpq	T	A	4: 126,915,926 (GRCm39)	H239Q	unknown	Het
St6gal2	A	T	17: 55,789,111 (GRCm39)	R48S	probably benign	Het
Sybu	T	C	15: 44,536,355 (GRCm39)	D657G	possibly damaging	Het
Syt15	A	G	14: 33,944,950 (GRCm39)	I166V	probably benign	Het
Tbcd	T	C	11: 121,499,474 (GRCm39)	S1093P	probably damaging	Het
Tfap2c	G	A	2: 172,399,015 (GRCm39)	V396M	possibly damaging	Het
Tnxb	C	T	17: 34,911,329 (GRCm39)	T1544I	possibly damaging	Het
Trim28	A	G	7: 12,762,341 (GRCm39)	T322A	probably damaging	Het
Tubgcp3	G	A	8: 12,707,626 (GRCm39)	A121V	possibly damaging	Het
Vmn2r14	A	T	5: 109,372,431 (GRCm39)	W20R	probably null	Het
Zfp551	A	G	7: 12,149,943 (GRCm39)	F489L	possibly damaging	Het

Other mutations in Taar7f

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00936:Taar7f	APN	10	23,926,066 (GRCm39)	missense	probably benign
IGL01618:Taar7f	APN	10	23,926,239 (GRCm39)	missense	possibly damaging	0.56
IGL02567:Taar7f	APN	10	23,926,323 (GRCm39)	missense	probably damaging	0.97
R0096:Taar7f	UTSW	10	23,926,152 (GRCm39)	missense	probably benign	0.00
R0139:Taar7f	UTSW	10	23,926,312 (GRCm39)	missense	probably benign	0.04
R0363:Taar7f	UTSW	10	23,925,839 (GRCm39)	missense	probably damaging	1.00
R1776:Taar7f	UTSW	10	23,925,546 (GRCm39)	missense	probably benign	0.14
R1952:Taar7f	UTSW	10	23,925,747 (GRCm39)	missense	probably damaging	1.00
R2049:Taar7f	UTSW	10	23,926,323 (GRCm39)	missense	possibly damaging	0.65
R2280:Taar7f	UTSW	10	23,925,417 (GRCm39)	missense	probably benign
R4210:Taar7f	UTSW	10	23,925,921 (GRCm39)	missense	probably damaging	1.00
R4211:Taar7f	UTSW	10	23,925,921 (GRCm39)	missense	probably damaging	1.00
R4587:Taar7f	UTSW	10	23,926,473 (GRCm39)	missense	probably damaging	0.97
R5092:Taar7f	UTSW	10	23,925,451 (GRCm39)	missense	probably benign
R5512:Taar7f	UTSW	10	23,926,321 (GRCm39)	missense	possibly damaging	0.89
R7439:Taar7f	UTSW	10	23,925,885 (GRCm39)	missense	possibly damaging	0.88
R7441:Taar7f	UTSW	10	23,925,885 (GRCm39)	missense	possibly damaging	0.88
R7839:Taar7f	UTSW	10	23,925,967 (GRCm39)	missense	possibly damaging	0.90
R8326:Taar7f	UTSW	10	23,925,811 (GRCm39)	missense	possibly damaging	0.81
R9443:Taar7f	UTSW	10	23,926,311 (GRCm39)	missense	probably benign	0.00
R9687:Taar7f	UTSW	10	23,925,727 (GRCm39)	missense	probably benign	0.19
RF021:Taar7f	UTSW	10	23,926,321 (GRCm39)	missense	possibly damaging	0.89

Predicted Primers

PCR Primer
(F):5'- AAGAGTCTTCTTGTCATTAGGAAGG -3'
(R):5'- TACCAAGAAGTCAGCACAGG -3'

Sequencing Primer
(F):5'- GTCTTCTTGTCATTAGGAAGGTATAC -3'
(R):5'- ATGCCACCAGGAAGTTGGC -3'

Posted On

2015-02-05