Incidental Mutation 'R3155:Pawr'
ID 263466
Institutional Source Beutler Lab
Gene Symbol Pawr
Ensembl Gene ENSMUSG00000035873
Gene Name PRKC, apoptosis, WT1, regulator
Synonyms Par4, Par-4, 2310001G03Rik
MMRRC Submission 040606-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.411) question?
Stock # R3155 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 108167982-108250101 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 108245370 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 193 (T193A)
Ref Sequence ENSEMBL: ENSMUSP00000151457 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095313] [ENSMUST00000218332]
AlphaFold Q925B0
Predicted Effect probably benign
Transcript: ENSMUST00000095313
AA Change: T237A

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000092951
Gene: ENSMUSG00000035873
AA Change: T237A

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
low complexity region 33 51 N/A INTRINSIC
low complexity region 66 80 N/A INTRINSIC
low complexity region 105 116 N/A INTRINSIC
coiled coil region 256 333 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000218332
AA Change: T193A

PolyPhen 2 Score 0.082 (Sensitivity: 0.93; Specificity: 0.85)
Meta Mutation Damage Score 0.0598 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 100% (39/39)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene show lower levels of apoptosis and increased proliferation of both T cells and B cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933407L21Rik T C 1: 85,859,104 (GRCm39) probably benign Het
Aco1 T C 4: 40,182,915 (GRCm39) V487A probably damaging Het
Adh1 A G 3: 137,986,250 (GRCm39) E79G probably damaging Het
Aebp1 A G 11: 5,821,425 (GRCm39) N608S probably benign Het
Ahctf1 G A 1: 179,583,148 (GRCm39) R43C probably damaging Het
Ahnak A T 19: 8,987,541 (GRCm39) I2942L possibly damaging Het
Anxa9 A T 3: 95,209,716 (GRCm39) D134E probably benign Het
Ccdc14 A G 16: 34,544,222 (GRCm39) D860G probably damaging Het
Cdhr3 T A 12: 33,099,152 (GRCm39) I480F possibly damaging Het
Cldn34a C T X: 151,346,840 (GRCm39) H171Y probably benign Het
Cyp2d9 T A 15: 82,336,843 (GRCm39) probably null Het
Dmbt1 T A 7: 130,651,887 (GRCm39) Y376* probably null Het
Fancm T C 12: 65,163,195 (GRCm39) I1453T probably benign Het
Fbxw11 A G 11: 32,689,244 (GRCm39) I456V possibly damaging Het
Fut2 A T 7: 45,300,091 (GRCm39) L227Q probably damaging Het
Gbp5 T C 3: 142,208,888 (GRCm39) probably null Het
Glrp1 C A 1: 88,430,976 (GRCm39) Q131H unknown Het
Gm6871 T C 7: 41,223,079 (GRCm39) N3S probably benign Het
H2-Eb1 C A 17: 34,533,348 (GRCm39) T190K probably damaging Het
Kdr T A 5: 76,129,065 (GRCm39) I194F probably benign Het
Klhdc7a A G 4: 139,694,500 (GRCm39) V149A probably benign Het
Lrit3 A G 3: 129,585,044 (GRCm39) F238S probably benign Het
Map10 A T 8: 126,398,313 (GRCm39) I569F possibly damaging Het
Myh6 A G 14: 55,182,125 (GRCm39) I1761T probably damaging Het
Npc1l1 A C 11: 6,171,840 (GRCm39) D874E probably benign Het
Or4k15c T C 14: 50,321,982 (GRCm39) D52G probably benign Het
Or8c17 T A 9: 38,179,836 (GRCm39) M1K probably null Het
Ppp2r3d T C 9: 101,089,559 (GRCm39) K255E possibly damaging Het
Rbp3 A T 14: 33,679,071 (GRCm39) K1006N probably damaging Het
Rif1 GCCACCA GCCA 2: 52,000,336 (GRCm39) probably benign Het
Rin2 A G 2: 145,702,771 (GRCm39) K489R probably benign Het
Rlf A G 4: 121,006,529 (GRCm39) V817A probably damaging Het
Rusc1 T C 3: 88,999,038 (GRCm39) D248G probably benign Het
Slc15a4 A G 5: 127,681,600 (GRCm39) probably null Het
Stk4 T A 2: 163,993,663 (GRCm39) M98K probably benign Het
Taf15 T A 11: 83,393,599 (GRCm39) H307Q probably benign Het
Urgcp A T 11: 5,666,327 (GRCm39) F670L probably damaging Het
Vmn2r76 T C 7: 85,874,959 (GRCm39) T673A probably damaging Het
Zfp324 G A 7: 12,702,817 (GRCm39) M60I probably damaging Het
Other mutations in Pawr
AlleleSourceChrCoordTypePredicted EffectPPH Score
R8865:Pawr UTSW 10 108,218,603 (GRCm39) missense probably damaging 1.00
R8985:Pawr UTSW 10 108,247,861 (GRCm39) missense possibly damaging 0.83
R9117:Pawr UTSW 10 108,169,140 (GRCm39) missense probably damaging 1.00
Z1177:Pawr UTSW 10 108,169,032 (GRCm39) missense possibly damaging 0.81
Predicted Primers PCR Primer
(F):5'- TGGGGATTCAGTTCTACGGC -3'
(R):5'- GAGTAGAACCGGATGTCTCCTG -3'

Sequencing Primer
(F):5'- GATTCAGTTCTACGGCAGAAAAC -3'
(R):5'- ATGTCTCCTGCCTGGGTGTC -3'
Posted On 2015-02-05