Incidental Mutation 'R3156:Yeats4'
ID 263505
Institutional Source Beutler Lab
Gene Symbol Yeats4
Ensembl Gene ENSMUSG00000020171
Gene Name YEATS domain containing 4
Synonyms GAS41, B230215M10Rik, 4930573H17Rik, NuBI-1
MMRRC Submission 040607-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.964) question?
Stock # R3156 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 117051126-117060412 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 117058186 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 22 (V22I)
Ref Sequence ENSEMBL: ENSMUSP00000020382 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020382] [ENSMUST00000218887]
AlphaFold Q9CR11
Predicted Effect probably benign
Transcript: ENSMUST00000020382
AA Change: V22I

PolyPhen 2 Score 0.113 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000020382
Gene: ENSMUSG00000020171
AA Change: V22I

DomainStartEndE-ValueType
Pfam:YEATS 44 124 4.6e-38 PFAM
low complexity region 152 163 N/A INTRINSIC
coiled coil region 178 226 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218027
Predicted Effect probably benign
Transcript: ENSMUST00000218887
AA Change: V22I

PolyPhen 2 Score 0.095 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219609
Meta Mutation Damage Score 0.1138 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 98% (39/40)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933407L21Rik T C 1: 85,859,104 (GRCm39) probably benign Het
Adra2b T C 2: 127,205,570 (GRCm39) L29P probably damaging Het
Anxa9 A T 3: 95,209,716 (GRCm39) D134E probably benign Het
Atad1 A T 19: 32,684,355 (GRCm39) N14K probably benign Het
Cbl T C 9: 44,070,147 (GRCm39) I533M possibly damaging Het
Cdca2 T C 14: 67,935,612 (GRCm39) N368D possibly damaging Het
Cfap45 A T 1: 172,373,291 (GRCm39) N543Y possibly damaging Het
Col4a2 T A 8: 11,363,414 (GRCm39) probably benign Het
Dis3l T C 9: 64,219,032 (GRCm39) T633A probably benign Het
Dnah5 G A 15: 28,438,237 (GRCm39) probably benign Het
Fut2 A T 7: 45,300,091 (GRCm39) L227Q probably damaging Het
Gcnt2 T C 13: 41,014,654 (GRCm39) V275A probably benign Het
Glrp1 C A 1: 88,430,976 (GRCm39) Q131H unknown Het
Gm6871 T C 7: 41,223,079 (GRCm39) N3S probably benign Het
Hmgcs1 C T 13: 120,166,614 (GRCm39) T402I probably benign Het
Hps6 A G 19: 45,992,180 (GRCm39) D39G probably damaging Het
Mab21l4 T A 1: 93,087,764 (GRCm39) I30F possibly damaging Het
Mycbp2 A T 14: 103,446,179 (GRCm39) probably benign Het
Myh6 A G 14: 55,182,125 (GRCm39) I1761T probably damaging Het
Neo1 T C 9: 58,796,262 (GRCm39) probably null Het
Or4k15c T C 14: 50,321,982 (GRCm39) D52G probably benign Het
Or7g27 A G 9: 19,250,720 (GRCm39) probably null Het
Patj A G 4: 98,562,465 (GRCm39) E1478G probably damaging Het
Paxbp1 T C 16: 90,832,878 (GRCm39) T304A probably benign Het
Rbp3 A T 14: 33,679,071 (GRCm39) K1006N probably damaging Het
Rif1 GCCACCA GCCA 2: 52,000,336 (GRCm39) probably benign Het
Ror2 G T 13: 53,271,400 (GRCm39) N306K probably damaging Het
Rusc1 T C 3: 88,999,038 (GRCm39) D248G probably benign Het
Secisbp2 A G 13: 51,816,711 (GRCm39) T288A probably benign Het
Setbp1 A G 18: 78,902,518 (GRCm39) V383A probably benign Het
Sez6 T A 11: 77,844,605 (GRCm39) S143T possibly damaging Het
Slc5a9 A T 4: 111,747,421 (GRCm39) I322N possibly damaging Het
Szt2 A G 4: 118,260,016 (GRCm39) probably null Het
Tex2 A G 11: 106,424,695 (GRCm39) probably null Het
Tonsl A T 15: 76,523,721 (GRCm39) L64Q probably damaging Het
Triml2 A G 8: 43,640,716 (GRCm39) N191D probably benign Het
Trpc1 C T 9: 95,603,185 (GRCm39) probably null Het
Other mutations in Yeats4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02383:Yeats4 APN 10 117,051,716 (GRCm39) missense probably benign 0.01
R0305:Yeats4 UTSW 10 117,051,741 (GRCm39) missense probably damaging 0.99
R1606:Yeats4 UTSW 10 117,053,344 (GRCm39) missense probably damaging 1.00
R1703:Yeats4 UTSW 10 117,051,628 (GRCm39) missense probably benign
R1907:Yeats4 UTSW 10 117,051,636 (GRCm39) missense probably benign 0.17
R3625:Yeats4 UTSW 10 117,056,273 (GRCm39) missense probably benign 0.08
R5687:Yeats4 UTSW 10 117,051,585 (GRCm39) missense probably benign
R7900:Yeats4 UTSW 10 117,056,464 (GRCm39) missense possibly damaging 0.95
R8347:Yeats4 UTSW 10 117,053,374 (GRCm39) missense probably benign 0.26
R8514:Yeats4 UTSW 10 117,051,660 (GRCm39) missense possibly damaging 0.50
R9665:Yeats4 UTSW 10 117,053,343 (GRCm39) nonsense probably null
R9688:Yeats4 UTSW 10 117,051,586 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGGGAGTCTATAATGGACCCAC -3'
(R):5'- CATTGTGCCAACGTTAGTGAATG -3'

Sequencing Primer
(F):5'- TATAATGGACCCACCTCATACTTGG -3'
(R):5'- CCAACGTTAGTGAATGTGACGCTG -3'
Posted On 2015-02-05