Incidental Mutation 'R3158:Krt6a'
ID 263602
Institutional Source Beutler Lab
Gene Symbol Krt6a
Ensembl Gene ENSMUSG00000058354
Gene Name keratin 6A
Synonyms Krt2-6a, MK6a, Krt2-6c, mK6[a]
MMRRC Submission 040609-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.197) question?
Stock # R3158 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 101598363-101602740 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 101599801 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 437 (Y437C)
Ref Sequence ENSEMBL: ENSMUSP00000023788 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023788]
AlphaFold P50446
Predicted Effect probably damaging
Transcript: ENSMUST00000023788
AA Change: Y437C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000023788
Gene: ENSMUSG00000058354
AA Change: Y437C

DomainStartEndE-ValueType
Pfam:Keratin_2_head 15 148 4.1e-36 PFAM
Filament 151 464 7.2e-178 SMART
low complexity region 483 551 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196874
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229164
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230205
Meta Mutation Damage Score 0.9640 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.4%
Validation Efficiency 97% (35/36)
MGI Phenotype PHENOTYPE: Mice homozygous for a targeted null mutation exhibit delayed wound healing. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aoc2 A T 11: 101,220,102 (GRCm39) N696I probably damaging Het
Ccr4 G T 9: 114,321,350 (GRCm39) N238K probably benign Het
Cd300e A C 11: 114,952,849 (GRCm39) M1R probably null Het
Cep95 A G 11: 106,700,013 (GRCm39) probably benign Het
Cfap54 T C 10: 92,834,918 (GRCm39) I1096V probably benign Het
Clca4b C A 3: 144,617,878 (GRCm39) V742L probably benign Het
Diaph3 A T 14: 86,893,892 (GRCm39) I39N possibly damaging Het
Dll3 A T 7: 27,993,520 (GRCm39) D566E possibly damaging Het
Dmpk A G 7: 18,826,944 (GRCm39) T579A probably benign Het
E330034G19Rik A T 14: 24,346,965 (GRCm39) Y84F possibly damaging Het
Eya1 G A 1: 14,374,691 (GRCm39) probably benign Het
Fat4 A G 3: 38,944,940 (GRCm39) T1278A possibly damaging Het
Galnt12 A G 4: 47,104,264 (GRCm39) D174G probably damaging Het
Gm20939 T A 17: 95,184,721 (GRCm39) H456Q probably damaging Het
Gm7853 A G 14: 35,811,358 (GRCm39) noncoding transcript Het
Hsd3b5 G A 3: 98,529,375 (GRCm39) A85V probably benign Het
Itga11 A G 9: 62,676,560 (GRCm39) K916R probably benign Het
Kcnh8 GAGACCAACGAGCAGCTGATGCTTCAGA GAGA 17: 53,032,934 (GRCm39) 74 probably benign Het
Lrp5 A G 19: 3,665,849 (GRCm39) S707P probably damaging Het
Med14 G A X: 12,550,330 (GRCm39) probably benign Het
Mmp11 C T 10: 75,762,948 (GRCm39) probably benign Het
Mtus2 A G 5: 148,168,637 (GRCm39) H950R probably damaging Het
Myo1g G T 11: 6,464,527 (GRCm39) T511K possibly damaging Het
Myo7a A G 7: 97,701,499 (GRCm39) F2154S probably damaging Het
Or11h4 A G 14: 50,974,271 (GRCm39) V116A probably benign Het
Or5b101 G C 19: 13,005,411 (GRCm39) A94G probably benign Het
Or8h8 C T 2: 86,752,950 (GRCm39) E309K probably benign Het
Prss52 G T 14: 64,350,992 (GRCm39) W259L probably damaging Het
Sbk2 G A 7: 4,960,526 (GRCm39) R215* probably null Het
Sectm1a A G 11: 120,959,603 (GRCm39) I175T probably benign Het
Smu1 T A 4: 40,754,529 (GRCm39) R123S possibly damaging Het
Stk3 A G 15: 35,008,387 (GRCm39) S178P possibly damaging Het
Tle6 T C 10: 81,431,038 (GRCm39) probably null Het
Vmn2r37 C T 7: 9,220,713 (GRCm39) M383I probably benign Het
Other mutations in Krt6a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00493:Krt6a APN 15 101,601,229 (GRCm39) missense probably damaging 1.00
IGL00596:Krt6a APN 15 101,602,665 (GRCm39) missense possibly damaging 0.53
PIT4468001:Krt6a UTSW 15 101,602,352 (GRCm39) missense probably damaging 0.98
R0024:Krt6a UTSW 15 101,599,150 (GRCm39) splice site probably benign
R0024:Krt6a UTSW 15 101,599,150 (GRCm39) splice site probably benign
R0811:Krt6a UTSW 15 101,601,183 (GRCm39) missense probably damaging 1.00
R0812:Krt6a UTSW 15 101,601,183 (GRCm39) missense probably damaging 1.00
R0828:Krt6a UTSW 15 101,602,271 (GRCm39) missense probably damaging 0.99
R0924:Krt6a UTSW 15 101,599,235 (GRCm39) splice site probably benign
R1525:Krt6a UTSW 15 101,602,637 (GRCm39) missense probably benign
R1591:Krt6a UTSW 15 101,600,792 (GRCm39) splice site probably null
R1725:Krt6a UTSW 15 101,600,992 (GRCm39) missense probably damaging 1.00
R1962:Krt6a UTSW 15 101,599,900 (GRCm39) missense probably damaging 1.00
R2201:Krt6a UTSW 15 101,601,606 (GRCm39) missense probably benign 0.41
R3024:Krt6a UTSW 15 101,599,724 (GRCm39) missense probably benign 0.02
R5369:Krt6a UTSW 15 101,600,993 (GRCm39) missense probably benign 0.06
R5637:Krt6a UTSW 15 101,600,714 (GRCm39) missense probably benign 0.25
R6164:Krt6a UTSW 15 101,601,008 (GRCm39) missense probably damaging 0.99
R6320:Krt6a UTSW 15 101,600,744 (GRCm39) missense probably damaging 0.99
R6562:Krt6a UTSW 15 101,600,094 (GRCm39) missense probably benign 0.36
R7267:Krt6a UTSW 15 101,602,289 (GRCm39) missense probably benign 0.03
R7560:Krt6a UTSW 15 101,598,994 (GRCm39) missense unknown
R7621:Krt6a UTSW 15 101,600,187 (GRCm39) missense possibly damaging 0.92
R7671:Krt6a UTSW 15 101,598,978 (GRCm39) missense unknown
R8017:Krt6a UTSW 15 101,602,304 (GRCm39) missense probably damaging 1.00
R8019:Krt6a UTSW 15 101,602,304 (GRCm39) missense probably damaging 1.00
R8318:Krt6a UTSW 15 101,602,682 (GRCm39) start codon destroyed probably null 0.02
R8508:Krt6a UTSW 15 101,601,170 (GRCm39) missense probably damaging 1.00
R9183:Krt6a UTSW 15 101,601,446 (GRCm39) missense probably benign 0.03
R9652:Krt6a UTSW 15 101,599,120 (GRCm39) missense probably benign 0.35
X0067:Krt6a UTSW 15 101,602,212 (GRCm39) missense possibly damaging 0.83
Predicted Primers PCR Primer
(F):5'- AAAGGGACTATTGTGGGCATAGTC -3'
(R):5'- TGCTCACCAGAAACCATGGTC -3'

Sequencing Primer
(F):5'- TGGGCATAGTCAGTGCTCC -3'
(R):5'- TCAGCCTCTGCAGAGATGTAC -3'
Posted On 2015-02-05