Mutagenetix > Incidental Mutation

Incidental Mutation 'R3112:Tas2r110'

263737

Institutional Source

Beutler Lab

Gene Symbol

Tas2r110

Ensembl Gene

ENSMUSG00000062952

Gene Name

taste receptor, type 2, member 110

Synonyms

T2R10, mt2r57, Tas2r10, STC 9-1

MMRRC Submission

040585-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

R3112 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

132844971-132845972 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 132844987 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Lysine at position 6 (I6K)

Ref Sequence

ENSEMBL: ENSMUSP00000080674 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000082014]

AlphaFold

Q7M712

Predicted Effect

unknown
Transcript: ENSMUST00000082014
AA Change: I6K

SMART Domains

Protein: ENSMUSP00000080674
Gene: ENSMUSG00000062952
AA Change: I6K

Domain	Start	End	E-Value	Type
Pfam:TAS2R	6	322	3.1e-82	PFAM

Meta Mutation Damage Score

0.0869

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 97.2%
20x: 94.9%

Validation Efficiency

100% (38/38)

Allele List at MGI

Other mutations in this stock

Total: 74 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca6	T	A	11: 110,069,655 (GRCm39)	K1554*	probably null	Het
Acads	T	C	5: 115,255,757 (GRCm39)	H26R	probably benign	Het
Acer1	G	A	17: 57,265,406 (GRCm39)	T141I	probably damaging	Het
Adam15	C	G	3: 89,254,764 (GRCm39)	V99L	probably benign	Het
Ankrd13b	A	G	11: 77,368,331 (GRCm39)	V97A	possibly damaging	Het
Anpep	T	C	7: 79,491,720 (GRCm39)	T94A	probably benign	Het
Atp1a3	T	C	7: 24,694,119 (GRCm39)	N345S	probably damaging	Het
Btn1a1	T	A	13: 23,645,721 (GRCm39)	N216I	possibly damaging	Het
Cacna1s	G	A	1: 136,002,831 (GRCm39)	W62*	probably null	Het
Ccdc141	C	T	2: 76,869,830 (GRCm39)	V892I	probably benign	Het
Ccdc180	T	A	4: 45,900,470 (GRCm39)	I278K	possibly damaging	Het
Cdc7	T	G	5: 107,122,564 (GRCm39)		probably null	Het
Cpb1	C	T	3: 20,319,521 (GRCm39)	V188M	probably damaging	Het
Dock5	A	G	14: 68,095,371 (GRCm39)	I101T	possibly damaging	Het
Dqx1	T	C	6: 83,035,953 (GRCm39)	V95A	probably damaging	Het
Dvl1	T	A	4: 155,938,123 (GRCm39)	D90E	probably damaging	Het
Fam135b	T	C	15: 71,335,879 (GRCm39)	I438M	probably benign	Het
Fpr1	A	T	17: 18,096,897 (GRCm39)	M364K	probably benign	Het
Gpat4	G	A	8: 23,670,171 (GRCm39)	P286L	probably damaging	Het
Gpx7	C	A	4: 108,260,470 (GRCm39)	V109F	probably damaging	Het
Grhl2	T	C	15: 37,336,591 (GRCm39)		probably null	Het
Grn	A	G	11: 102,324,069 (GRCm39)	T53A	probably benign	Het
H1f4	T	C	13: 23,805,829 (GRCm39)		probably benign	Het
H2-T9	T	C	17: 36,440,038 (GRCm39)	Y32C	probably damaging	Het
Hmgxb3	T	C	18: 61,280,454 (GRCm39)	N683S	probably damaging	Het
Iigp1	T	C	18: 60,523,983 (GRCm39)	I367T	probably benign	Het
Itfg2	T	C	6: 128,388,632 (GRCm39)	E285G	probably damaging	Het
Itgav	T	A	2: 83,622,915 (GRCm39)	C662*	probably null	Het
Jarid2	T	A	13: 45,059,752 (GRCm39)	N661K	probably damaging	Het
Lipe	T	C	7: 25,097,848 (GRCm39)	T32A	probably benign	Het
Lrrk2	A	G	15: 91,698,898 (GRCm39)	Y2475C	probably benign	Het
Mcc	T	C	18: 44,582,330 (GRCm39)	D607G	probably damaging	Het
Mip	T	A	10: 128,061,875 (GRCm39)	L42*	probably null	Het
Mlc1	A	T	15: 88,850,199 (GRCm39)	D192E	probably benign	Het
Muc2	T	C	7: 141,299,225 (GRCm39)		probably benign	Het
Mybl1	T	C	1: 9,752,095 (GRCm39)	D260G	probably damaging	Het
Ncln	C	T	10: 81,323,519 (GRCm39)	V51I	probably benign	Het
Nlrp9a	T	C	7: 26,257,297 (GRCm39)	V305A	probably benign	Het
Nodal	G	A	10: 61,260,276 (GRCm39)	R309Q	possibly damaging	Het
Olr1	T	C	6: 129,476,881 (GRCm39)	N128S	possibly damaging	Het
Or10ak14	A	T	4: 118,611,421 (GRCm39)	F105I	probably damaging	Het
Or12j5	A	G	7: 140,083,832 (GRCm39)	I180T	probably damaging	Het
Or14a256	T	C	7: 86,264,884 (GRCm39)	Y323C	probably benign	Het
Orc1	T	A	4: 108,461,757 (GRCm39)	C585S	probably benign	Het
Pcmtd2	A	T	2: 181,496,922 (GRCm39)	I300F	probably damaging	Het
Pfkfb4	C	T	9: 108,854,110 (GRCm39)		probably benign	Het
Phactr3	T	A	2: 177,920,810 (GRCm39)	L180Q	possibly damaging	Het
Pigo	T	C	4: 43,021,083 (GRCm39)	T612A	probably benign	Het
Plch1	T	A	3: 63,616,952 (GRCm39)	D766V	probably damaging	Het
Plekhh3	T	C	11: 101,054,973 (GRCm39)		probably benign	Het
Potefam1	T	G	2: 111,058,399 (GRCm39)	L131F	probably damaging	Het
Ppp1r12b	T	A	1: 134,800,570 (GRCm39)	T547S	probably damaging	Het
Prkcb	T	A	7: 122,116,079 (GRCm39)	M186K	probably damaging	Het
Prpf3	A	T	3: 95,757,112 (GRCm39)		probably benign	Het
Psg23	T	C	7: 18,344,369 (GRCm39)	D362G	possibly damaging	Het
Reg3a	T	C	6: 78,358,114 (GRCm39)	L15P	probably damaging	Het
Scrib	A	T	15: 75,941,223 (GRCm39)	I5N	probably damaging	Het
Speg	C	T	1: 75,399,326 (GRCm39)	Q2005*	probably null	Het
Sppl3	A	T	5: 115,212,923 (GRCm39)	S51C	possibly damaging	Het
Sspo	A	G	6: 48,434,534 (GRCm39)	T1009A	probably damaging	Het
Syce1l	A	G	8: 114,381,579 (GRCm39)	Q164R	probably benign	Het
Sympk	T	C	7: 18,768,409 (GRCm39)	V126A	possibly damaging	Het
Tas2r120	A	T	6: 132,634,731 (GRCm39)	H271L	probably damaging	Het
Tlcd3a	A	G	11: 76,093,057 (GRCm39)	D33G	probably benign	Het
Tnn	T	A	1: 159,943,856 (GRCm39)	T986S	possibly damaging	Het
Trim5	T	C	7: 103,928,845 (GRCm39)	H32R	probably damaging	Het
Ttc13	A	G	8: 125,410,573 (GRCm39)	I360T	possibly damaging	Het
Uaca	A	G	9: 60,778,781 (GRCm39)	E1054G	probably damaging	Het
Usp16	T	A	16: 87,268,736 (GRCm39)		probably null	Het
Wee1	T	A	7: 109,730,043 (GRCm39)	S382R	probably damaging	Het
Wnt11	T	C	7: 98,495,771 (GRCm39)	S92P	probably damaging	Het
Zfp1004	C	G	2: 150,034,141 (GRCm39)	P185R	probably damaging	Het
Zfp786	A	G	6: 47,797,160 (GRCm39)	C593R	probably damaging	Het
Zfp879	T	G	11: 50,723,989 (GRCm39)	I283L	possibly damaging	Het

Other mutations in Tas2r110

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03103:Tas2r110	APN	6	132,845,443 (GRCm39)	missense	probably benign	0.09
IGL03275:Tas2r110	APN	6	132,845,061 (GRCm39)	missense	probably damaging	0.99
R0111:Tas2r110	UTSW	6	132,845,166 (GRCm39)	missense	probably benign	0.00
R0539:Tas2r110	UTSW	6	132,845,334 (GRCm39)	missense	possibly damaging	0.63
R1432:Tas2r110	UTSW	6	132,845,331 (GRCm39)	missense	probably damaging	1.00
R1672:Tas2r110	UTSW	6	132,845,029 (GRCm39)	missense	probably damaging	1.00
R2483:Tas2r110	UTSW	6	132,845,433 (GRCm39)	missense	probably benign	0.00
R3110:Tas2r110	UTSW	6	132,844,987 (GRCm39)	missense	unknown
R3623:Tas2r110	UTSW	6	132,845,433 (GRCm39)	missense	probably benign	0.00
R3847:Tas2r110	UTSW	6	132,845,638 (GRCm39)	missense	probably damaging	1.00
R3849:Tas2r110	UTSW	6	132,845,638 (GRCm39)	missense	probably damaging	1.00
R3850:Tas2r110	UTSW	6	132,845,638 (GRCm39)	missense	probably damaging	1.00
R4871:Tas2r110	UTSW	6	132,845,091 (GRCm39)	missense	probably benign	0.09
R5010:Tas2r110	UTSW	6	132,845,438 (GRCm39)	nonsense	probably null
R5108:Tas2r110	UTSW	6	132,845,668 (GRCm39)	missense	probably damaging	1.00
R5289:Tas2r110	UTSW	6	132,844,972 (GRCm39)	start codon destroyed	probably null
R5938:Tas2r110	UTSW	6	132,845,016 (GRCm39)	missense	probably benign	0.39
R6262:Tas2r110	UTSW	6	132,845,638 (GRCm39)	missense	probably damaging	0.96
R6286:Tas2r110	UTSW	6	132,845,490 (GRCm39)	missense	probably benign	0.01
R6582:Tas2r110	UTSW	6	132,845,248 (GRCm39)	missense	possibly damaging	0.94
R7236:Tas2r110	UTSW	6	132,845,667 (GRCm39)	missense	possibly damaging	0.76
R8897:Tas2r110	UTSW	6	132,845,374 (GRCm39)	missense	probably damaging	1.00
X0024:Tas2r110	UTSW	6	132,845,596 (GRCm39)	missense	probably damaging	1.00
Z1176:Tas2r110	UTSW	6	132,845,574 (GRCm39)	missense	probably benign	0.37

Predicted Primers

PCR Primer
(F):5'- TGGATGAAGCAGAGGTGATCTC -3'
(R):5'- ACATAGAGAAATCTGGTAATGGCC -3'

Sequencing Primer
(F):5'- GAGGTGATCTCTTTGGGAAAA -3'
(R):5'- CCAAAGCAGTGAGAATCTGATCCG -3'

Posted On

2015-02-05