|Institutional Source||Beutler Lab|
|Gene Name||formyl peptide receptor 1|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R3110 (G1)|
|Chromosomal Location||17876471-17883940 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to T at 17876635 bp|
|Amino Acid Change||Methionine to Lysine at position 364 (M364K)|
|Ref Sequence||ENSEMBL: ENSMUSP00000052894 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000061516]|
|Predicted Effect||probably benign
AA Change: M364K
PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
AA Change: M364K
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||98% (51/52)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]
PHENOTYPE: Targeted null mice are viable and developmentally normal but show increased susceptibility to L. monocytogenes challenge, as shown by increased mortality and bacterial burden in liver/spleen early post-infection. Mutant neutrophils fail to respond to fMLF either in calcium flux or chemotaxis assays. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Fpr1||
(F):5'- GGCCTGTGAGTGAACTAAGTG -3'
(R):5'- AGCTGCCTCAATCCAATGC -3'
(F):5'- CGCTATAGTACTAACTGTCATTTGG -3'
(R):5'- AGCTGCCTCAATCCAATGCTTTATG -3'