Incidental Mutation 'R3115:Or10g3'
ID 263996
Institutional Source Beutler Lab
Gene Symbol Or10g3
Ensembl Gene ENSMUSG00000094140
Gene Name olfactory receptor family 10 subfamily G member 3
Synonyms GA_x6K02T2RJGY-622120-623061, MOR223-5, Olfr1512
MMRRC Submission 040588-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.113) question?
Stock # R3115 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 52609567-52610508 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 52610397 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 38 (T38A)
Ref Sequence ENSEMBL: ENSMUSP00000149717 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071221] [ENSMUST00000214980]
AlphaFold Q8VF72
Predicted Effect probably damaging
Transcript: ENSMUST00000071221
AA Change: T38A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000071208
Gene: ENSMUSG00000094140
AA Change: T38A

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 2.1e-48 PFAM
Pfam:7tm_1 41 290 2.9e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192537
Predicted Effect noncoding transcript
Transcript: ENSMUST00000200261
Predicted Effect probably damaging
Transcript: ENSMUST00000214980
AA Change: T38A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.1732 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.1%
Validation Efficiency 96% (47/49)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc12 A G 8: 87,266,653 (GRCm39) probably null Het
Abcc9 T C 6: 142,634,755 (GRCm39) T170A probably benign Het
Agbl2 T C 2: 90,636,245 (GRCm39) S594P possibly damaging Het
Aoc1l3 A G 6: 48,964,331 (GRCm39) Y113C probably damaging Het
Atf7 C T 15: 102,442,858 (GRCm39) S417N probably benign Het
Cacng7 T C 7: 3,387,450 (GRCm39) V111A probably benign Het
Chrm4 A G 2: 91,757,705 (GRCm39) T38A probably benign Het
Cnot1 T C 8: 96,470,906 (GRCm39) E1314G possibly damaging Het
Dcx A G X: 142,706,105 (GRCm39) Y229H probably damaging Het
Espl1 T A 15: 102,231,639 (GRCm39) F1945Y possibly damaging Het
Glul T C 1: 153,783,038 (GRCm39) F204L possibly damaging Het
Grm2 A G 9: 106,524,822 (GRCm39) V631A probably damaging Het
Ifi205 T A 1: 173,855,901 (GRCm39) Y43F possibly damaging Het
Irs3 A G 5: 137,642,118 (GRCm39) L440P probably benign Het
Itpr1 A G 6: 108,383,070 (GRCm39) D1466G possibly damaging Het
Jarid2 T C 13: 45,049,942 (GRCm39) S257P probably damaging Het
Knl1 C A 2: 118,900,872 (GRCm39) L858M possibly damaging Het
Krt24 T A 11: 99,173,262 (GRCm39) T298S possibly damaging Het
Lrriq1 C T 10: 103,006,294 (GRCm39) R1277Q probably benign Het
Mgp A C 6: 136,849,683 (GRCm39) Y92D probably damaging Het
Micu3 A G 8: 40,835,208 (GRCm39) H521R probably benign Het
Mier3 T A 13: 111,843,182 (GRCm39) I178N probably damaging Het
Moxd1 G T 10: 24,177,429 (GRCm39) E582* probably null Het
Mprip T A 11: 59,656,229 (GRCm39) probably null Het
Mybph A G 1: 134,122,476 (GRCm39) I174V probably benign Het
Mynn C T 3: 30,661,959 (GRCm39) T347M probably damaging Het
Nhsl1 A T 10: 18,400,916 (GRCm39) Q714L probably damaging Het
Nr1d2 A T 14: 18,215,504 (GRCm38) probably null Het
Or2a5 T C 6: 42,873,784 (GRCm39) V133A probably benign Het
Or52h9 C A 7: 104,202,295 (GRCm39) H56Q probably benign Het
Or5p61 T C 7: 107,759,029 (GRCm39) E17G probably benign Het
Pcdha4 T C 18: 37,086,603 (GRCm39) V262A probably benign Het
Pde4d T A 13: 110,084,792 (GRCm39) M519K probably damaging Het
Phactr2 C A 10: 13,137,645 (GRCm39) E166* probably null Het
Prdx4 C T X: 154,113,407 (GRCm39) R167Q probably damaging Het
Prkdc C T 16: 15,482,222 (GRCm39) L422F probably benign Het
Prph T A 15: 98,953,337 (GRCm39) F84I probably damaging Het
Rnmt A G 18: 68,447,079 (GRCm39) E321G probably benign Het
Serpinb13 A T 1: 106,910,568 (GRCm39) E64V probably null Het
Slc12a4 A T 8: 106,686,091 (GRCm39) S81T probably damaging Het
Slc47a1 A G 11: 61,258,506 (GRCm39) L179P possibly damaging Het
Sp140l2 C G 1: 85,235,106 (GRCm39) probably benign Het
Spata31e5 A C 1: 28,815,410 (GRCm39) V874G possibly damaging Het
Sycp2l C A 13: 41,302,274 (GRCm39) T456K probably benign Het
Tenm2 A G 11: 35,914,193 (GRCm39) L2447P probably damaging Het
Tll1 A G 8: 64,506,900 (GRCm39) C614R probably damaging Het
Usp5 T C 6: 124,792,560 (GRCm39) Y826C probably damaging Het
Vmn2r71 A C 7: 85,272,866 (GRCm39) D560A probably damaging Het
Wdr91 A G 6: 34,882,522 (GRCm39) L209P probably damaging Het
Zfp511 T A 7: 139,616,504 (GRCm39) D46E probably benign Het
Zfp81 C T 17: 33,553,537 (GRCm39) A426T possibly damaging Het
Zscan22 T C 7: 12,641,217 (GRCm39) I328T probably benign Het
Other mutations in Or10g3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01328:Or10g3 APN 14 52,609,967 (GRCm39) missense probably damaging 1.00
IGL01375:Or10g3 APN 14 52,609,865 (GRCm39) missense probably damaging 0.99
IGL02343:Or10g3 APN 14 52,609,934 (GRCm39) missense probably damaging 1.00
R1443:Or10g3 UTSW 14 52,610,408 (GRCm39) missense probably damaging 1.00
R1902:Or10g3 UTSW 14 52,610,174 (GRCm39) missense possibly damaging 0.81
R1903:Or10g3 UTSW 14 52,610,174 (GRCm39) missense possibly damaging 0.81
R4752:Or10g3 UTSW 14 52,609,764 (GRCm39) missense probably damaging 1.00
R5345:Or10g3 UTSW 14 52,609,725 (GRCm39) nonsense probably null
R5689:Or10g3 UTSW 14 52,610,214 (GRCm39) missense possibly damaging 0.83
R6185:Or10g3 UTSW 14 52,610,019 (GRCm39) missense possibly damaging 0.91
R6287:Or10g3 UTSW 14 52,609,748 (GRCm39) missense probably damaging 1.00
R6757:Or10g3 UTSW 14 52,610,172 (GRCm39) missense probably damaging 1.00
R8751:Or10g3 UTSW 14 52,610,420 (GRCm39) missense probably benign 0.03
R8855:Or10g3 UTSW 14 52,610,196 (GRCm39) missense probably damaging 1.00
R8866:Or10g3 UTSW 14 52,610,196 (GRCm39) missense probably damaging 1.00
R9038:Or10g3 UTSW 14 52,609,716 (GRCm39) missense probably damaging 0.99
R9450:Or10g3 UTSW 14 52,610,110 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TAGGAAACACTGGGAACTTCC -3'
(R):5'- CCACTTGCGCATCATCTATG -3'

Sequencing Primer
(F):5'- GGAACTTCCCAGAAAGTGGTAG -3'
(R):5'- ATGCTAACCCCTGCTTGTCTG -3'
Posted On 2015-02-05