Incidental Mutation 'R3116:Or2a5'
ID 264020
Institutional Source Beutler Lab
Gene Symbol Or2a5
Ensembl Gene ENSMUSG00000043119
Gene Name olfactory receptor family 2 subfamily A member 5
Synonyms Olfr448, MOR261-13, GA_x6K02T2P3E9-4663051-4662119
MMRRC Submission 040589-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.107) question?
Stock # R3116 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 42873387-42874319 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 42873784 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 133 (V133A)
Ref Sequence ENSEMBL: ENSMUSP00000148884 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058668] [ENSMUST00000213952] [ENSMUST00000214529]
AlphaFold Q8VES9
Predicted Effect probably benign
Transcript: ENSMUST00000058668
AA Change: V133A

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000059195
Gene: ENSMUSG00000043119
AA Change: V133A

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 1.8e-61 PFAM
Pfam:7tm_1 40 289 5.3e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213952
AA Change: V133A

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
Predicted Effect probably benign
Transcript: ENSMUST00000214529
AA Change: V133A

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
Meta Mutation Damage Score 0.1110 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb4 A T 5: 8,946,610 (GRCm39) I37F possibly damaging Het
Aoc1l3 A G 6: 48,964,331 (GRCm39) Y113C probably damaging Het
Ccdc146 T C 5: 21,521,953 (GRCm39) N357S probably benign Het
Csmd3 A G 15: 47,520,995 (GRCm39) F2783S probably damaging Het
Desi2 T A 1: 178,072,008 (GRCm39) M104K probably damaging Het
Disp1 C T 1: 182,870,486 (GRCm39) V645I probably benign Het
Dock8 A T 19: 25,165,858 (GRCm39) H1914L probably benign Het
Fdft1 T C 14: 63,415,147 (GRCm39) I28M probably benign Het
Ffar3 T C 7: 30,555,231 (GRCm39) M30V probably benign Het
Grm3 A T 5: 9,620,752 (GRCm39) F164Y probably damaging Het
Ints5 T C 19: 8,872,136 (GRCm39) S32P possibly damaging Het
Itgam T A 7: 127,715,201 (GRCm39) S908R probably damaging Het
Kif20b C T 19: 34,947,480 (GRCm39) P1565L probably benign Het
Kntc1 A G 5: 123,940,121 (GRCm39) E1610G probably damaging Het
Krt24 T A 11: 99,173,262 (GRCm39) T298S possibly damaging Het
Magoh T C 4: 107,744,409 (GRCm39) V126A possibly damaging Het
Marchf6 G A 15: 31,486,265 (GRCm39) S362F probably benign Het
Meak7 G A 8: 120,495,056 (GRCm39) A234V probably benign Het
Mier3 T A 13: 111,843,182 (GRCm39) I178N probably damaging Het
Moxd1 G T 10: 24,177,429 (GRCm39) E582* probably null Het
Ncor2 A T 5: 125,101,230 (GRCm39) L2195Q probably damaging Het
Neil1 A T 9: 57,053,947 (GRCm39) D124E probably benign Het
Nhsl1 A T 10: 18,400,916 (GRCm39) Q714L probably damaging Het
Nipbl T A 15: 8,373,076 (GRCm39) M1057L probably benign Het
Npas3 G A 12: 54,114,508 (GRCm39) probably null Het
Oas1h C T 5: 120,999,679 (GRCm39) Q55* probably null Het
Or2ag2b T A 7: 106,417,571 (GRCm39) F94I probably damaging Het
Or52h9 C A 7: 104,202,295 (GRCm39) H56Q probably benign Het
Or5p61 T C 7: 107,759,029 (GRCm39) E17G probably benign Het
Or7d9 A T 9: 20,197,523 (GRCm39) H176L probably benign Het
Phactr2 C A 10: 13,137,645 (GRCm39) E166* probably null Het
Prkdc C T 16: 15,482,222 (GRCm39) L422F probably benign Het
Pum1 T C 4: 130,499,971 (GRCm39) V1051A probably damaging Het
Pxdn T C 12: 30,052,306 (GRCm39) S828P possibly damaging Het
Rad21 T A 15: 51,828,397 (GRCm39) E557V probably null Het
Rtn3 T G 19: 7,409,355 (GRCm39) N888H probably damaging Het
Slc12a5 T A 2: 164,838,101 (GRCm39) probably null Het
Slc7a11 T A 3: 50,338,588 (GRCm39) M274L probably benign Het
Tacc2 A G 7: 130,360,979 (GRCm39) N825S probably damaging Het
Tln2 T A 9: 67,262,421 (GRCm39) D610V probably benign Het
Tmed11 C T 5: 108,927,705 (GRCm39) V110M probably damaging Het
Tmem92 T C 11: 94,673,254 (GRCm39) D3G possibly damaging Het
Trp53rkb C T 2: 166,636,009 (GRCm39) probably benign Het
Wdr91 A G 6: 34,882,522 (GRCm39) L209P probably damaging Het
Zfp511 T A 7: 139,616,504 (GRCm39) D46E probably benign Het
Zfp804a C A 2: 82,089,761 (GRCm39) Q1197K probably damaging Het
Other mutations in Or2a5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00937:Or2a5 APN 6 42,873,568 (GRCm39) missense probably damaging 1.00
IGL02888:Or2a5 APN 6 42,874,263 (GRCm39) missense probably damaging 1.00
R0830:Or2a5 UTSW 6 42,873,532 (GRCm39) missense probably benign 0.06
R1173:Or2a5 UTSW 6 42,874,285 (GRCm39) missense probably benign 0.11
R1846:Or2a5 UTSW 6 42,874,254 (GRCm39) missense probably damaging 0.99
R1913:Or2a5 UTSW 6 42,873,687 (GRCm39) missense probably damaging 0.97
R2178:Or2a5 UTSW 6 42,873,732 (GRCm39) missense probably benign
R3115:Or2a5 UTSW 6 42,873,784 (GRCm39) missense probably benign 0.01
R4717:Or2a5 UTSW 6 42,874,158 (GRCm39) missense probably damaging 1.00
R5358:Or2a5 UTSW 6 42,873,454 (GRCm39) missense probably benign 0.11
R6249:Or2a5 UTSW 6 42,874,238 (GRCm39) missense probably damaging 0.98
R6860:Or2a5 UTSW 6 42,873,750 (GRCm39) missense probably benign 0.35
R7122:Or2a5 UTSW 6 42,874,024 (GRCm39) missense probably damaging 0.99
R8924:Or2a5 UTSW 6 42,873,964 (GRCm39) missense probably damaging 1.00
R8988:Or2a5 UTSW 6 42,874,201 (GRCm39) missense
R9507:Or2a5 UTSW 6 42,873,835 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- CTTGACTGCAGACTCCACAC -3'
(R):5'- TGTCAGCACAGACCAACTTAAGG -3'

Sequencing Primer
(F):5'- GGCCATCGTCGATATTTCATATG -3'
(R):5'- AAAATGGCAGCCTCAGGA -3'
Posted On 2015-02-05