Incidental Mutation 'R3122:Or4c31'
ID 264087
Institutional Source Beutler Lab
Gene Symbol Or4c31
Ensembl Gene ENSMUSG00000049372
Gene Name olfactory receptor family 4 subfamily C member 31
Synonyms MOR230-6, GA_x6K02T2Q125-49948903-49949814, Olfr1183
MMRRC Submission 040595-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R3122 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 88291686-88292597 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 88291853 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 75 (M75I)
Ref Sequence ENSEMBL: ENSMUSP00000154094 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102618] [ENSMUST00000213115] [ENSMUST00000219871]
AlphaFold A0A2I3BQA3
Predicted Effect possibly damaging
Transcript: ENSMUST00000102618
AA Change: M56I

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000099678
Gene: ENSMUSG00000049372
AA Change: M56I

DomainStartEndE-ValueType
Pfam:7tm_4 28 302 1.1e-47 PFAM
Pfam:7TM_GPCR_Srsx 32 299 1.8e-5 PFAM
Pfam:7tm_1 38 284 1.5e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213115
AA Change: M75I

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
Predicted Effect possibly damaging
Transcript: ENSMUST00000219871
AA Change: M56I

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
Meta Mutation Damage Score 0.2245 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.3%
Validation Efficiency 100% (48/48)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam18 T C 8: 25,118,248 (GRCm39) N8S possibly damaging Het
Ago3 A G 4: 126,311,165 (GRCm39) I16T probably benign Het
Alms1 C A 6: 85,644,945 (GRCm39) probably benign Het
Brdt A G 5: 107,525,011 (GRCm39) T851A probably damaging Het
Capn7 A T 14: 31,081,167 (GRCm39) I395F probably damaging Het
Ccbe1 A G 18: 66,199,900 (GRCm39) M274T probably benign Het
Ccdc146 T C 5: 21,499,591 (GRCm39) R864G possibly damaging Het
Ccdc17 G T 4: 116,456,749 (GRCm39) probably benign Het
Ccdc85a C A 11: 28,533,499 (GRCm39) C15F unknown Het
Cpt1c A G 7: 44,609,345 (GRCm39) Y715H probably damaging Het
Dmwd T A 7: 18,814,620 (GRCm39) F423L probably damaging Het
Dock3 C G 9: 106,788,542 (GRCm39) A1598P probably damaging Het
Ext2 A G 2: 93,644,170 (GRCm39) L37P probably damaging Het
Fam120a T C 13: 49,045,562 (GRCm39) D758G possibly damaging Het
Foxn4 T C 5: 114,396,776 (GRCm39) T236A probably damaging Het
Gm9776 A T 13: 94,495,194 (GRCm39) probably benign Het
Grik1 A T 16: 87,803,361 (GRCm39) M277K probably damaging Het
H2-T23 T A 17: 36,341,855 (GRCm39) M248L probably benign Het
Hephl1 A G 9: 15,000,265 (GRCm39) F329S possibly damaging Het
Kif13a G A 13: 46,918,072 (GRCm39) probably benign Het
Knl1 T A 2: 118,899,425 (GRCm39) H375Q probably benign Het
Lox A G 18: 52,658,177 (GRCm39) F332S probably damaging Het
Ltf G A 9: 110,851,968 (GRCm39) C135Y probably damaging Het
Madd A G 2: 91,006,554 (GRCm39) Y347H probably damaging Het
Mboat1 T C 13: 30,422,031 (GRCm39) Y387H probably damaging Het
Mrc2 G A 11: 105,239,257 (GRCm39) probably null Het
Naip1 T C 13: 100,545,503 (GRCm39) T1342A probably damaging Het
Naip6 T C 13: 100,453,031 (GRCm39) D10G probably benign Het
Nudt8 A G 19: 4,052,015 (GRCm39) R209G possibly damaging Het
Or56a3 T C 7: 104,735,385 (GRCm39) V154A probably benign Het
Or8k35 A T 2: 86,424,954 (GRCm39) Y73N possibly damaging Het
Orc4 G A 2: 48,827,501 (GRCm39) P31S probably benign Het
Phactr1 T A 13: 43,213,049 (GRCm39) S131T possibly damaging Het
Phactr3 A G 2: 177,973,411 (GRCm39) I475V probably damaging Het
Pip T A 6: 41,828,819 (GRCm39) N121K probably damaging Het
Pla2g4d T C 2: 120,109,384 (GRCm39) R222G probably benign Het
Rbm42 A G 7: 30,349,152 (GRCm39) probably benign Het
Sowahb T C 5: 93,191,261 (GRCm39) D486G possibly damaging Het
Svep1 C T 4: 58,087,845 (GRCm39) V1745I possibly damaging Het
Tnfsf15 T A 4: 63,652,522 (GRCm39) E96D probably benign Het
Vmn1r217 A G 13: 23,298,249 (GRCm39) S218P probably damaging Het
Vmn2r129 G T 4: 156,686,692 (GRCm39) noncoding transcript Het
Vmn2r71 T G 7: 85,264,828 (GRCm39) Y53* probably null Het
Wapl A G 14: 34,451,172 (GRCm39) I729M possibly damaging Het
Wrnip1 A G 13: 32,986,744 (GRCm39) D175G probably benign Het
Zscan2 G A 7: 80,513,092 (GRCm39) A26T probably benign Het
Other mutations in Or4c31
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00163:Or4c31 APN 2 88,291,696 (GRCm39) missense probably benign
IGL01150:Or4c31 APN 2 88,292,419 (GRCm39) missense possibly damaging 0.93
IGL02894:Or4c31 APN 2 88,292,070 (GRCm39) missense probably damaging 1.00
R0382:Or4c31 UTSW 2 88,292,069 (GRCm39) missense possibly damaging 0.87
R0401:Or4c31 UTSW 2 88,292,269 (GRCm39) missense probably damaging 1.00
R0664:Or4c31 UTSW 2 88,292,515 (GRCm39) missense probably damaging 1.00
R1990:Or4c31 UTSW 2 88,291,686 (GRCm39) start codon destroyed probably null
R4596:Or4c31 UTSW 2 88,292,538 (GRCm39) missense probably benign 0.28
R7361:Or4c31 UTSW 2 88,291,836 (GRCm39) missense probably benign 0.28
R7469:Or4c31 UTSW 2 88,291,691 (GRCm39) missense probably benign
R7858:Or4c31 UTSW 2 88,292,056 (GRCm39) missense probably damaging 1.00
R8023:Or4c31 UTSW 2 88,292,022 (GRCm39) missense probably benign 0.04
R8147:Or4c31 UTSW 2 88,292,427 (GRCm39) missense possibly damaging 0.93
R9026:Or4c31 UTSW 2 88,292,196 (GRCm39) missense probably damaging 1.00
R9103:Or4c31 UTSW 2 88,291,942 (GRCm39) missense probably benign 0.02
Z1176:Or4c31 UTSW 2 88,292,458 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCAGGTTAAATATTTGTGCTCTACC -3'
(R):5'- TCAATGGCCATGAGGATAAGC -3'

Sequencing Primer
(F):5'- CTATTACAGCCACTGATAAGATGC -3'
(R):5'- GGATAAGCACGAAGATCTCCATGC -3'
Posted On 2015-02-05