Incidental Mutation 'R3151:Ano2'
ID 264398
Institutional Source Beutler Lab
Gene Symbol Ano2
Ensembl Gene ENSMUSG00000038115
Gene Name anoctamin 2
Synonyms Tmem16b
MMRRC Submission 040603-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.102) question?
Stock # R3151 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 125667382-126017089 bp(+) (GRCm39)
Type of Mutation splice site (5 bp from exon)
DNA Base Change (assembly) G to A at 125990280 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000125303 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000159984] [ENSMUST00000160496]
AlphaFold Q8CFW1
Predicted Effect probably benign
Transcript: ENSMUST00000159984
SMART Domains Protein: ENSMUSP00000123965
Gene: ENSMUSG00000038115

DomainStartEndE-ValueType
Pfam:Anoctamin 21 181 1.7e-41 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000160496
SMART Domains Protein: ENSMUSP00000125303
Gene: ENSMUSG00000038115

DomainStartEndE-ValueType
low complexity region 60 69 N/A INTRINSIC
Pfam:Anoct_dimer 91 348 5.7e-78 PFAM
Pfam:Anoctamin 351 941 6.7e-138 PFAM
low complexity region 964 991 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000161619
SMART Domains Protein: ENSMUSP00000125426
Gene: ENSMUSG00000038115

DomainStartEndE-ValueType
low complexity region 63 74 N/A INTRINSIC
Pfam:Anoctamin 262 425 1.9e-39 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency 98% (61/62)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] ANO2 belongs to a family of calcium-activated chloride channels (CaCCs) (reviewed by Hartzell et al., 2009 [PubMed 19015192]).[supplied by OMIM, Jan 2011]
PHENOTYPE: Mice homozygous for a knock-out allele lack calcium-activated chloride currents in the main olfactory epithelium and vomeronasal organ but normal olfaction in behavioral tasks. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam5 A G 8: 25,271,647 (GRCm39) Y587H probably damaging Het
Ahnak T C 19: 8,987,308 (GRCm39) V2864A probably benign Het
Arl5c A G 11: 97,883,159 (GRCm39) I147T probably damaging Het
Asap2 T A 12: 21,274,378 (GRCm39) F369I probably damaging Het
Atg4a-ps A G 3: 103,553,228 (GRCm39) F38L probably benign Het
B230217C12Rik TGTGTCG TG 11: 97,733,014 (GRCm39) probably null Het
Cacna1s A T 1: 136,033,532 (GRCm39) Y1003F probably damaging Het
Ccdc178 A T 18: 21,944,618 (GRCm39) M847K probably benign Het
Clca4b T C 3: 144,621,272 (GRCm39) K601E probably benign Het
Cnih4 A G 1: 180,981,292 (GRCm39) probably benign Het
Cnpy3 A T 17: 47,058,452 (GRCm39) V57E probably damaging Het
Creb3l1 T A 2: 91,832,378 (GRCm39) E48V probably damaging Het
Dus3l T A 17: 57,075,899 (GRCm39) F482I probably benign Het
Dync1i2 A G 2: 71,064,060 (GRCm39) probably benign Het
Echdc1 A G 10: 29,198,360 (GRCm39) T102A possibly damaging Het
Elf1 G A 14: 79,804,755 (GRCm39) probably null Het
Elp1 T C 4: 56,770,985 (GRCm39) Y986C probably benign Het
Ep400 G T 5: 110,851,435 (GRCm39) T1349N unknown Het
Eps15 T A 4: 109,223,419 (GRCm39) D458E probably benign Het
F2rl2 G A 13: 95,837,638 (GRCm39) V228I probably benign Het
Fads3 T G 19: 10,035,262 (GRCm39) S438A probably benign Het
Fcgbp T A 7: 27,816,665 (GRCm39) C2376S probably damaging Het
Fndc3b A G 3: 27,473,652 (GRCm39) S1138P possibly damaging Het
Ggt5 T C 10: 75,445,076 (GRCm39) I361T probably benign Het
Gpr158 C T 2: 21,581,771 (GRCm39) R417W possibly damaging Het
Gria1 A G 11: 57,174,388 (GRCm39) I626V probably damaging Het
Gys2 T C 6: 142,402,059 (GRCm39) E260G probably benign Het
Ido2 T A 8: 25,023,776 (GRCm39) Y354F possibly damaging Het
Igkv6-23 A G 6: 70,237,543 (GRCm39) L66P probably benign Het
Kremen1 T C 11: 5,145,012 (GRCm39) K455E probably damaging Het
Krtap19-9b T C 16: 88,729,096 (GRCm39) S2G unknown Het
Magea1 A T X: 153,872,093 (GRCm39) M211K probably benign Het
Mtx2 G A 2: 74,677,634 (GRCm39) probably null Het
Nlrp14 G A 7: 106,781,759 (GRCm39) V319I probably benign Het
Nphs1 A T 7: 30,159,665 (GRCm39) T33S probably benign Het
Or12j2 A T 7: 139,916,243 (GRCm39) H156L probably benign Het
Or2t6 T A 14: 14,175,203 (GRCm38) N293I probably damaging Het
Or3a1c A T 11: 74,046,466 (GRCm39) H162L probably damaging Het
P2rx7 A G 5: 122,819,329 (GRCm39) T584A probably benign Het
Pclo A G 5: 14,571,692 (GRCm39) Q359R probably damaging Het
Phtf2 T C 5: 20,970,802 (GRCm39) E147G probably damaging Het
Ptges2 G A 2: 32,286,488 (GRCm39) A68T probably benign Het
Rab33b A T 3: 51,401,069 (GRCm39) N181I possibly damaging Het
Rnf213 A T 11: 119,359,718 (GRCm39) R4370S probably benign Het
Rpf1 G A 3: 146,213,390 (GRCm39) R254W probably damaging Het
Serpinb7 A T 1: 107,363,081 (GRCm39) R82* probably null Het
Setbp1 A G 18: 78,900,650 (GRCm39) S1006P probably damaging Het
Spata31d1a T C 13: 59,849,180 (GRCm39) S983G probably benign Het
Ssr2 T C 3: 88,487,323 (GRCm39) I46T probably damaging Het
Ssx2ip G A 3: 146,124,138 (GRCm39) G51D probably benign Het
Synj1 A T 16: 90,757,514 (GRCm39) L878H probably damaging Het
Th G A 7: 142,447,812 (GRCm39) Q329* probably null Het
Tln2 C T 9: 67,237,829 (GRCm39) probably null Het
Trio A G 15: 27,805,862 (GRCm39) L542P probably damaging Het
Trp53bp2 A G 1: 182,256,525 (GRCm39) T32A probably damaging Het
Vmn1r40 A T 6: 89,691,548 (GRCm39) T122S probably benign Het
Vmn2r121 C T X: 123,040,849 (GRCm39) C494Y probably benign Het
Vmn2r51 A T 7: 9,833,968 (GRCm39) Y357N probably damaging Het
Vmn2r55 G T 7: 12,404,634 (GRCm39) S256R probably benign Het
Vps8 A G 16: 21,261,123 (GRCm39) T88A probably benign Het
Zfp977 A C 7: 42,229,870 (GRCm39) N218K probably benign Het
Other mutations in Ano2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00766:Ano2 APN 6 125,990,216 (GRCm39) missense probably damaging 1.00
IGL01387:Ano2 APN 6 125,990,240 (GRCm39) missense probably damaging 0.99
IGL01772:Ano2 APN 6 126,013,821 (GRCm39) missense probably damaging 0.98
IGL01931:Ano2 APN 6 125,959,708 (GRCm39) missense probably damaging 1.00
IGL02066:Ano2 APN 6 125,667,702 (GRCm39) missense probably benign 0.07
IGL02410:Ano2 APN 6 125,792,496 (GRCm39) critical splice acceptor site probably null
IGL02526:Ano2 APN 6 125,849,714 (GRCm39) critical splice donor site probably null
IGL03116:Ano2 APN 6 125,957,134 (GRCm39) nonsense probably null
IGL03183:Ano2 APN 6 125,687,592 (GRCm39) missense probably benign
IGL03391:Ano2 APN 6 125,784,802 (GRCm39) missense probably damaging 1.00
R0257:Ano2 UTSW 6 125,857,676 (GRCm39) missense probably benign 0.05
R0462:Ano2 UTSW 6 125,689,238 (GRCm39) missense probably benign 0.26
R0594:Ano2 UTSW 6 125,959,728 (GRCm39) missense probably damaging 1.00
R1072:Ano2 UTSW 6 126,016,287 (GRCm39) missense probably damaging 1.00
R1099:Ano2 UTSW 6 125,784,810 (GRCm39) missense probably damaging 1.00
R1436:Ano2 UTSW 6 125,844,134 (GRCm39) critical splice donor site probably null
R1468:Ano2 UTSW 6 125,773,227 (GRCm39) missense probably damaging 1.00
R1468:Ano2 UTSW 6 125,773,227 (GRCm39) missense probably damaging 1.00
R1822:Ano2 UTSW 6 125,840,420 (GRCm39) missense probably damaging 1.00
R1901:Ano2 UTSW 6 125,849,647 (GRCm39) missense probably damaging 1.00
R1902:Ano2 UTSW 6 125,849,647 (GRCm39) missense probably damaging 1.00
R1911:Ano2 UTSW 6 125,990,654 (GRCm39) missense probably benign 0.00
R2040:Ano2 UTSW 6 126,016,471 (GRCm39) missense probably benign 0.13
R2192:Ano2 UTSW 6 125,992,502 (GRCm39) missense probably damaging 1.00
R2307:Ano2 UTSW 6 125,969,849 (GRCm39) missense probably benign 0.00
R2698:Ano2 UTSW 6 125,689,309 (GRCm39) missense probably benign 0.01
R2878:Ano2 UTSW 6 125,840,481 (GRCm39) missense probably damaging 1.00
R4004:Ano2 UTSW 6 125,990,242 (GRCm39) missense probably damaging 1.00
R4664:Ano2 UTSW 6 125,840,501 (GRCm39) missense probably benign 0.07
R4684:Ano2 UTSW 6 125,767,304 (GRCm39) missense probably benign 0.00
R4685:Ano2 UTSW 6 125,957,087 (GRCm39) nonsense probably null
R4686:Ano2 UTSW 6 125,767,254 (GRCm39) missense probably benign 0.10
R4852:Ano2 UTSW 6 125,959,886 (GRCm39) missense possibly damaging 0.95
R4923:Ano2 UTSW 6 125,880,018 (GRCm39) utr 3 prime probably benign
R5488:Ano2 UTSW 6 126,016,216 (GRCm39) missense possibly damaging 0.46
R5513:Ano2 UTSW 6 126,016,285 (GRCm39) missense possibly damaging 0.88
R5699:Ano2 UTSW 6 125,849,703 (GRCm39) missense probably damaging 1.00
R5876:Ano2 UTSW 6 126,016,242 (GRCm39) missense possibly damaging 0.92
R6175:Ano2 UTSW 6 125,969,918 (GRCm39) missense probably benign 0.15
R6219:Ano2 UTSW 6 125,792,553 (GRCm39) missense probably damaging 1.00
R6613:Ano2 UTSW 6 125,783,619 (GRCm39) splice site probably null
R6711:Ano2 UTSW 6 125,752,795 (GRCm39) missense probably damaging 1.00
R6982:Ano2 UTSW 6 125,969,856 (GRCm39) missense probably benign
R7153:Ano2 UTSW 6 125,969,906 (GRCm39) missense possibly damaging 0.73
R7182:Ano2 UTSW 6 125,767,256 (GRCm39) missense probably damaging 0.99
R7312:Ano2 UTSW 6 126,016,460 (GRCm39) nonsense probably null
R7358:Ano2 UTSW 6 125,687,696 (GRCm39) missense probably benign
R7456:Ano2 UTSW 6 125,940,508 (GRCm39) missense probably benign 0.01
R7532:Ano2 UTSW 6 125,940,667 (GRCm39) missense probably damaging 1.00
R7607:Ano2 UTSW 6 125,689,382 (GRCm39) missense probably damaging 1.00
R7623:Ano2 UTSW 6 125,992,536 (GRCm39) nonsense probably null
R7690:Ano2 UTSW 6 125,990,161 (GRCm39) missense probably damaging 1.00
R8273:Ano2 UTSW 6 125,959,683 (GRCm39) missense probably damaging 1.00
R8389:Ano2 UTSW 6 125,957,132 (GRCm39) missense probably damaging 0.99
R8392:Ano2 UTSW 6 125,857,698 (GRCm39) missense probably benign 0.02
R8479:Ano2 UTSW 6 125,689,123 (GRCm39) missense possibly damaging 0.61
R8488:Ano2 UTSW 6 125,957,133 (GRCm39) missense probably damaging 1.00
R8746:Ano2 UTSW 6 125,840,513 (GRCm39) missense probably benign 0.14
R9136:Ano2 UTSW 6 125,959,962 (GRCm39) missense probably damaging 0.98
R9680:Ano2 UTSW 6 125,857,382 (GRCm39) critical splice acceptor site probably null
R9752:Ano2 UTSW 6 125,840,499 (GRCm39) missense probably damaging 1.00
Z1176:Ano2 UTSW 6 125,840,416 (GRCm39) nonsense probably null
Z1176:Ano2 UTSW 6 125,687,670 (GRCm39) missense probably benign
Z1177:Ano2 UTSW 6 125,992,610 (GRCm39) missense probably damaging 1.00
Z1177:Ano2 UTSW 6 125,990,170 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATAAGGGATGGGCTTTGCTCC -3'
(R):5'- GGGGTAGTTAAATGACTTCCACTG -3'

Sequencing Primer
(F):5'- GCTGAAGCCTCTCCTGTGTG -3'
(R):5'- TGGCCTTCCCACATCCAAGG -3'
Posted On 2015-02-05