Incidental Mutation 'R3153:Or5m13b'
ID 264443
Institutional Source Beutler Lab
Gene Symbol Or5m13b
Ensembl Gene ENSMUSG00000042863
Gene Name olfactory receptor family 5 subfamily M member 13B
Synonyms Olfr1026, MOR196-4, GA_x6K02T2Q125-47402610-47403533
MMRRC Submission 040604-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R3153 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 85753614-85754537 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 85754074 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 154 (V154A)
Ref Sequence ENSEMBL: ENSMUSP00000151927 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056718] [ENSMUST00000188749] [ENSMUST00000213474] [ENSMUST00000217615] [ENSMUST00000219615]
AlphaFold Q7TR90
Predicted Effect probably benign
Transcript: ENSMUST00000056718
AA Change: V154A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000049887
Gene: ENSMUSG00000042863
AA Change: V154A

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 6.1e-58 PFAM
Pfam:7tm_1 41 290 9e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000188749
SMART Domains Protein: ENSMUSP00000139860
Gene: ENSMUSG00000058884

DomainStartEndE-ValueType
low complexity region 26 40 N/A INTRINSIC
Pfam:7tm_1 41 290 5.7e-30 PFAM
Pfam:7tm_4 139 283 7.8e-48 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213474
Predicted Effect probably benign
Transcript: ENSMUST00000217615
AA Change: V154A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000219615
AA Change: V154A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6820408C15Rik A C 2: 152,282,744 (GRCm39) N200H probably damaging Het
Abca17 T A 17: 24,547,720 (GRCm39) D218V probably damaging Het
Abhd12 A G 2: 150,676,275 (GRCm39) F361L probably benign Het
Abr A T 11: 76,377,295 (GRCm39) I59N probably damaging Het
Agbl1 A G 7: 76,369,944 (GRCm39) E681G probably damaging Het
B3gnt4 G T 5: 123,648,716 (GRCm39) R27L probably benign Het
Cct8l1 A C 5: 25,722,137 (GRCm39) E284A probably damaging Het
Chd7 T A 4: 8,855,174 (GRCm39) N2134K probably benign Het
Chrna3 C T 9: 54,923,334 (GRCm39) C158Y probably damaging Het
Cndp2 C A 18: 84,686,722 (GRCm39) M433I probably benign Het
Cnnm3 T A 1: 36,560,303 (GRCm39) S608T probably damaging Het
Cnot1 T C 8: 96,470,906 (GRCm39) E1314G possibly damaging Het
Col20a1 C T 2: 180,650,386 (GRCm39) P1074L probably damaging Het
Coq6 G A 12: 84,418,309 (GRCm39) V298M probably damaging Het
Cpt1a A G 19: 3,406,430 (GRCm39) Y132C probably damaging Het
Dcdc2a A C 13: 25,286,340 (GRCm39) I125L probably benign Het
Eps8l1 A T 7: 4,474,798 (GRCm39) I321F probably damaging Het
Fancd2 A G 6: 113,570,230 (GRCm39) S1394G possibly damaging Het
Fcrl5 T C 3: 87,350,987 (GRCm39) F166L probably benign Het
Gatc T C 5: 115,473,546 (GRCm39) E131G probably benign Het
Gpld1 T C 13: 25,127,603 (GRCm39) S2P unknown Het
Gprc5b G A 7: 118,575,770 (GRCm39) P385L probably damaging Het
Gsc2 G A 16: 17,732,364 (GRCm39) R137W probably damaging Het
Hsd3b1 T C 3: 98,759,980 (GRCm39) D337G probably damaging Het
Ireb2 T C 9: 54,793,230 (GRCm39) probably null Het
Kank1 T A 19: 25,388,052 (GRCm39) V575E possibly damaging Het
Kcnmb1 A T 11: 33,916,339 (GRCm39) D95V probably damaging Het
L3mbtl4 T A 17: 68,764,243 (GRCm39) Y125* probably null Het
Lce1h C T 3: 92,670,982 (GRCm39) G57R unknown Het
Lgalsl A G 11: 20,776,487 (GRCm39) F135S probably damaging Het
Lrba A G 3: 86,192,526 (GRCm39) M147V probably damaging Het
Mdm2 T C 10: 117,545,618 (GRCm39) E23G possibly damaging Het
Mthfd1 C A 12: 76,358,737 (GRCm39) Q67K probably benign Het
Mtus2 T C 5: 148,019,870 (GRCm39) L755P probably damaging Het
Orc3 A G 4: 34,575,124 (GRCm39) F587L probably damaging Het
Pcdhb7 C T 18: 37,476,126 (GRCm39) P421S probably damaging Het
Pgk2 T A 17: 40,519,134 (GRCm39) D98V probably damaging Het
Pkd1l1 A C 11: 8,817,207 (GRCm39) S1364A probably benign Het
Rin3 A C 12: 102,334,800 (GRCm39) E157A unknown Het
Rnf126 A T 10: 79,597,465 (GRCm39) I149N probably damaging Het
Rph3a T C 5: 121,111,440 (GRCm39) T47A probably damaging Het
Sap18 T C 14: 58,039,402 (GRCm39) M68T probably benign Het
Sfrp2 A G 3: 83,680,577 (GRCm39) T246A probably benign Het
Slc18a3 A G 14: 32,185,228 (GRCm39) V385A probably benign Het
Slitrk3 C T 3: 72,956,315 (GRCm39) W819* probably null Het
Smap1 A T 1: 23,892,630 (GRCm39) D111E probably damaging Het
Spesp1 G A 9: 62,189,376 (GRCm39) probably benign Het
Styk1 A T 6: 131,286,975 (GRCm39) Y84* probably null Het
Sv2a T A 3: 96,092,574 (GRCm39) D91E possibly damaging Het
Tbc1d5 A G 17: 51,275,264 (GRCm39) I77T probably damaging Het
Trim10 T A 17: 37,182,580 (GRCm39) C149S probably damaging Het
Zbtb38 T C 9: 96,570,302 (GRCm39) K261E probably benign Het
Zfp202 T C 9: 40,119,734 (GRCm39) L179P probably benign Het
Zkscan5 T A 5: 145,149,437 (GRCm39) S251R probably benign Het
Other mutations in Or5m13b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01701:Or5m13b APN 2 85,754,421 (GRCm39) missense possibly damaging 0.81
PIT4151001:Or5m13b UTSW 2 85,754,386 (GRCm39) missense probably damaging 1.00
R0147:Or5m13b UTSW 2 85,754,362 (GRCm39) missense possibly damaging 0.61
R0601:Or5m13b UTSW 2 85,753,722 (GRCm39) missense probably benign 0.01
R0899:Or5m13b UTSW 2 85,753,731 (GRCm39) missense probably benign
R1728:Or5m13b UTSW 2 85,754,466 (GRCm39) missense possibly damaging 0.48
R2004:Or5m13b UTSW 2 85,753,939 (GRCm39) splice site probably null
R2020:Or5m13b UTSW 2 85,754,087 (GRCm39) missense probably benign
R2396:Or5m13b UTSW 2 85,754,269 (GRCm39) missense probably benign 0.00
R2519:Or5m13b UTSW 2 85,753,951 (GRCm39) missense probably damaging 1.00
R4696:Or5m13b UTSW 2 85,749,215 (GRCm39) splice site probably null
R5034:Or5m13b UTSW 2 85,753,891 (GRCm39) missense probably damaging 0.99
R5221:Or5m13b UTSW 2 85,754,493 (GRCm39) missense probably damaging 1.00
R5334:Or5m13b UTSW 2 85,754,058 (GRCm39) missense probably damaging 1.00
R6041:Or5m13b UTSW 2 85,753,735 (GRCm39) missense probably damaging 1.00
R7602:Or5m13b UTSW 2 85,754,146 (GRCm39) missense probably damaging 1.00
R8075:Or5m13b UTSW 2 85,754,470 (GRCm39) missense probably benign 0.18
R8697:Or5m13b UTSW 2 85,754,200 (GRCm39) missense possibly damaging 0.77
R8971:Or5m13b UTSW 2 85,754,328 (GRCm39) missense probably damaging 1.00
R9237:Or5m13b UTSW 2 85,754,267 (GRCm39) nonsense probably null
R9347:Or5m13b UTSW 2 85,753,819 (GRCm39) missense probably damaging 1.00
Z1088:Or5m13b UTSW 2 85,754,142 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTTGCCCCTCAGATGTTGG -3'
(R):5'- GAACAGGTGAGGTTGGATCC -3'

Sequencing Primer
(F):5'- GCCCCTCAGATGTTGGTTAAC -3'
(R):5'- TGAGGTTGGATCCTGCCAC -3'
Posted On 2015-02-05