Incidental Mutation 'R3153:Slitrk3'
ID 264447
Institutional Source Beutler Lab
Gene Symbol Slitrk3
Ensembl Gene ENSMUSG00000048304
Gene Name SLIT and NTRK-like family, member 3
Synonyms ST3
MMRRC Submission 040604-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.715) question?
Stock # R3153 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 72954598-72965136 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 72956315 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Stop codon at position 819 (W819*)
Ref Sequence ENSEMBL: ENSMUSP00000141236 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059407] [ENSMUST00000192477]
AlphaFold Q810B9
Predicted Effect probably null
Transcript: ENSMUST00000059407
AA Change: W819*
SMART Domains Protein: ENSMUSP00000088561
Gene: ENSMUSG00000048304
AA Change: W819*

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
Blast:LRRNT 44 79 3e-11 BLAST
LRR 101 124 2.08e1 SMART
LRR 125 148 6.05e0 SMART
LRR 149 172 3.97e0 SMART
LRR_TYP 173 196 1.67e-2 SMART
LRR 197 220 2.69e2 SMART
LRRCT 233 283 4.56e-5 SMART
low complexity region 332 350 N/A INTRINSIC
LRRNT 373 411 4.17e0 SMART
LRR 432 455 1.62e0 SMART
LRR_TYP 456 479 2.61e-4 SMART
LRR 480 503 2.82e0 SMART
LRR_TYP 504 527 6.99e-5 SMART
LRRCT 563 613 3.22e-5 SMART
transmembrane domain 658 680 N/A INTRINSIC
low complexity region 713 724 N/A INTRINSIC
low complexity region 836 843 N/A INTRINSIC
low complexity region 846 858 N/A INTRINSIC
low complexity region 870 888 N/A INTRINSIC
Blast:LRRCT 906 943 2e-16 BLAST
Predicted Effect probably null
Transcript: ENSMUST00000192477
AA Change: W819*
SMART Domains Protein: ENSMUSP00000141236
Gene: ENSMUSG00000048304
AA Change: W819*

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
Blast:LRRNT 44 79 3e-11 BLAST
LRR 101 124 2.08e1 SMART
LRR 125 148 6.05e0 SMART
LRR 149 172 3.97e0 SMART
LRR_TYP 173 196 1.67e-2 SMART
LRR 197 220 2.69e2 SMART
LRRCT 233 283 4.56e-5 SMART
low complexity region 332 350 N/A INTRINSIC
LRRNT 373 411 4.17e0 SMART
LRR 432 455 1.62e0 SMART
LRR_TYP 456 479 2.61e-4 SMART
LRR 480 503 2.82e0 SMART
LRR_TYP 504 527 6.99e-5 SMART
LRRCT 563 613 3.22e-5 SMART
transmembrane domain 658 680 N/A INTRINSIC
low complexity region 713 724 N/A INTRINSIC
low complexity region 836 843 N/A INTRINSIC
low complexity region 846 858 N/A INTRINSIC
low complexity region 870 888 N/A INTRINSIC
Blast:LRRCT 906 943 2e-16 BLAST
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Slitrk family of structurally related transmembrane proteins that are involved in controlling neurite outgrowth. The encoded protein contains two leucine-rich repeat (LRR) domains and a C-terminal domain that is partially similar to Trk neurotrophin receptor protein. Enhanced expression of this gene was found in tissue from several different types of tumors. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Jan 2016]
PHENOTYPE: Mice homozygous for a knock-out mice exhibit reduced inhibitory synapse density, decreased miniature inhibitory postsynaptic current frequency and increased susceptibility to spontaneous and pharmacologically-induced seizures. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6820408C15Rik A C 2: 152,282,744 (GRCm39) N200H probably damaging Het
Abca17 T A 17: 24,547,720 (GRCm39) D218V probably damaging Het
Abhd12 A G 2: 150,676,275 (GRCm39) F361L probably benign Het
Abr A T 11: 76,377,295 (GRCm39) I59N probably damaging Het
Agbl1 A G 7: 76,369,944 (GRCm39) E681G probably damaging Het
B3gnt4 G T 5: 123,648,716 (GRCm39) R27L probably benign Het
Cct8l1 A C 5: 25,722,137 (GRCm39) E284A probably damaging Het
Chd7 T A 4: 8,855,174 (GRCm39) N2134K probably benign Het
Chrna3 C T 9: 54,923,334 (GRCm39) C158Y probably damaging Het
Cndp2 C A 18: 84,686,722 (GRCm39) M433I probably benign Het
Cnnm3 T A 1: 36,560,303 (GRCm39) S608T probably damaging Het
Cnot1 T C 8: 96,470,906 (GRCm39) E1314G possibly damaging Het
Col20a1 C T 2: 180,650,386 (GRCm39) P1074L probably damaging Het
Coq6 G A 12: 84,418,309 (GRCm39) V298M probably damaging Het
Cpt1a A G 19: 3,406,430 (GRCm39) Y132C probably damaging Het
Dcdc2a A C 13: 25,286,340 (GRCm39) I125L probably benign Het
Eps8l1 A T 7: 4,474,798 (GRCm39) I321F probably damaging Het
Fancd2 A G 6: 113,570,230 (GRCm39) S1394G possibly damaging Het
Fcrl5 T C 3: 87,350,987 (GRCm39) F166L probably benign Het
Gatc T C 5: 115,473,546 (GRCm39) E131G probably benign Het
Gpld1 T C 13: 25,127,603 (GRCm39) S2P unknown Het
Gprc5b G A 7: 118,575,770 (GRCm39) P385L probably damaging Het
Gsc2 G A 16: 17,732,364 (GRCm39) R137W probably damaging Het
Hsd3b1 T C 3: 98,759,980 (GRCm39) D337G probably damaging Het
Ireb2 T C 9: 54,793,230 (GRCm39) probably null Het
Kank1 T A 19: 25,388,052 (GRCm39) V575E possibly damaging Het
Kcnmb1 A T 11: 33,916,339 (GRCm39) D95V probably damaging Het
L3mbtl4 T A 17: 68,764,243 (GRCm39) Y125* probably null Het
Lce1h C T 3: 92,670,982 (GRCm39) G57R unknown Het
Lgalsl A G 11: 20,776,487 (GRCm39) F135S probably damaging Het
Lrba A G 3: 86,192,526 (GRCm39) M147V probably damaging Het
Mdm2 T C 10: 117,545,618 (GRCm39) E23G possibly damaging Het
Mthfd1 C A 12: 76,358,737 (GRCm39) Q67K probably benign Het
Mtus2 T C 5: 148,019,870 (GRCm39) L755P probably damaging Het
Or5m13b T C 2: 85,754,074 (GRCm39) V154A probably benign Het
Orc3 A G 4: 34,575,124 (GRCm39) F587L probably damaging Het
Pcdhb7 C T 18: 37,476,126 (GRCm39) P421S probably damaging Het
Pgk2 T A 17: 40,519,134 (GRCm39) D98V probably damaging Het
Pkd1l1 A C 11: 8,817,207 (GRCm39) S1364A probably benign Het
Rin3 A C 12: 102,334,800 (GRCm39) E157A unknown Het
Rnf126 A T 10: 79,597,465 (GRCm39) I149N probably damaging Het
Rph3a T C 5: 121,111,440 (GRCm39) T47A probably damaging Het
Sap18 T C 14: 58,039,402 (GRCm39) M68T probably benign Het
Sfrp2 A G 3: 83,680,577 (GRCm39) T246A probably benign Het
Slc18a3 A G 14: 32,185,228 (GRCm39) V385A probably benign Het
Smap1 A T 1: 23,892,630 (GRCm39) D111E probably damaging Het
Spesp1 G A 9: 62,189,376 (GRCm39) probably benign Het
Styk1 A T 6: 131,286,975 (GRCm39) Y84* probably null Het
Sv2a T A 3: 96,092,574 (GRCm39) D91E possibly damaging Het
Tbc1d5 A G 17: 51,275,264 (GRCm39) I77T probably damaging Het
Trim10 T A 17: 37,182,580 (GRCm39) C149S probably damaging Het
Zbtb38 T C 9: 96,570,302 (GRCm39) K261E probably benign Het
Zfp202 T C 9: 40,119,734 (GRCm39) L179P probably benign Het
Zkscan5 T A 5: 145,149,437 (GRCm39) S251R probably benign Het
Other mutations in Slitrk3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00465:Slitrk3 APN 3 72,958,436 (GRCm39) missense probably damaging 1.00
IGL00857:Slitrk3 APN 3 72,957,174 (GRCm39) missense probably damaging 1.00
IGL00990:Slitrk3 APN 3 72,957,414 (GRCm39) missense probably damaging 1.00
IGL01010:Slitrk3 APN 3 72,956,606 (GRCm39) missense probably benign 0.14
IGL01299:Slitrk3 APN 3 72,956,349 (GRCm39) missense probably benign 0.43
IGL01609:Slitrk3 APN 3 72,957,570 (GRCm39) missense probably damaging 1.00
IGL01881:Slitrk3 APN 3 72,956,639 (GRCm39) missense probably benign 0.00
IGL01941:Slitrk3 APN 3 72,958,404 (GRCm39) missense possibly damaging 0.72
IGL02183:Slitrk3 APN 3 72,957,312 (GRCm39) missense probably damaging 0.97
IGL02187:Slitrk3 APN 3 72,957,605 (GRCm39) missense probably damaging 1.00
IGL02478:Slitrk3 APN 3 72,958,046 (GRCm39) missense probably damaging 0.96
IGL02512:Slitrk3 APN 3 72,957,735 (GRCm39) missense probably benign 0.28
IGL02720:Slitrk3 APN 3 72,958,101 (GRCm39) missense probably damaging 1.00
IGL03113:Slitrk3 APN 3 72,957,723 (GRCm39) missense probably benign 0.00
IGL03224:Slitrk3 APN 3 72,957,263 (GRCm39) missense possibly damaging 0.72
wee UTSW 3 72,958,118 (GRCm39) missense probably damaging 1.00
R0233:Slitrk3 UTSW 3 72,955,910 (GRCm39) missense probably benign 0.00
R0233:Slitrk3 UTSW 3 72,955,910 (GRCm39) missense probably benign 0.00
R0639:Slitrk3 UTSW 3 72,956,982 (GRCm39) missense probably benign 0.02
R1448:Slitrk3 UTSW 3 72,957,674 (GRCm39) missense probably damaging 0.99
R1656:Slitrk3 UTSW 3 72,957,672 (GRCm39) missense probably damaging 0.98
R1713:Slitrk3 UTSW 3 72,957,024 (GRCm39) missense probably benign 0.00
R1992:Slitrk3 UTSW 3 72,957,104 (GRCm39) missense possibly damaging 0.80
R1999:Slitrk3 UTSW 3 72,957,297 (GRCm39) missense probably benign 0.13
R2359:Slitrk3 UTSW 3 72,956,678 (GRCm39) missense possibly damaging 0.56
R3083:Slitrk3 UTSW 3 72,955,928 (GRCm39) missense probably benign 0.00
R3821:Slitrk3 UTSW 3 72,956,549 (GRCm39) missense possibly damaging 0.94
R4208:Slitrk3 UTSW 3 72,958,490 (GRCm39) missense possibly damaging 0.67
R4323:Slitrk3 UTSW 3 72,958,118 (GRCm39) missense probably damaging 1.00
R4580:Slitrk3 UTSW 3 72,958,539 (GRCm39) missense probably damaging 0.96
R4730:Slitrk3 UTSW 3 72,956,852 (GRCm39) missense probably benign 0.08
R4742:Slitrk3 UTSW 3 72,955,898 (GRCm39) missense probably benign 0.00
R4979:Slitrk3 UTSW 3 72,957,129 (GRCm39) missense possibly damaging 0.95
R5018:Slitrk3 UTSW 3 72,957,845 (GRCm39) missense probably benign 0.31
R5023:Slitrk3 UTSW 3 72,957,981 (GRCm39) missense probably benign 0.24
R5057:Slitrk3 UTSW 3 72,957,981 (GRCm39) missense probably benign 0.24
R5156:Slitrk3 UTSW 3 72,956,592 (GRCm39) missense probably benign
R5500:Slitrk3 UTSW 3 72,957,680 (GRCm39) missense probably damaging 1.00
R5582:Slitrk3 UTSW 3 72,957,737 (GRCm39) missense probably benign 0.09
R5797:Slitrk3 UTSW 3 72,955,962 (GRCm39) missense probably damaging 0.99
R5963:Slitrk3 UTSW 3 72,958,046 (GRCm39) missense probably benign 0.30
R5985:Slitrk3 UTSW 3 72,958,233 (GRCm39) missense probably damaging 1.00
R6123:Slitrk3 UTSW 3 72,957,095 (GRCm39) missense probably damaging 1.00
R6393:Slitrk3 UTSW 3 72,957,247 (GRCm39) missense possibly damaging 0.79
R6529:Slitrk3 UTSW 3 72,958,551 (GRCm39) missense probably benign 0.02
R6584:Slitrk3 UTSW 3 72,956,558 (GRCm39) missense probably damaging 0.99
R6645:Slitrk3 UTSW 3 72,957,194 (GRCm39) missense probably benign 0.13
R7001:Slitrk3 UTSW 3 72,957,942 (GRCm39) nonsense probably null
R7282:Slitrk3 UTSW 3 72,957,798 (GRCm39) missense possibly damaging 0.70
R7534:Slitrk3 UTSW 3 72,957,440 (GRCm39) missense probably damaging 0.98
R7577:Slitrk3 UTSW 3 72,958,448 (GRCm39) missense probably damaging 0.99
R7757:Slitrk3 UTSW 3 72,958,172 (GRCm39) missense probably damaging 1.00
R8251:Slitrk3 UTSW 3 72,956,729 (GRCm39) missense possibly damaging 0.67
R8354:Slitrk3 UTSW 3 72,956,513 (GRCm39) missense probably benign 0.08
R8454:Slitrk3 UTSW 3 72,956,513 (GRCm39) missense probably benign 0.08
R8488:Slitrk3 UTSW 3 72,958,520 (GRCm39) missense probably benign 0.02
R8491:Slitrk3 UTSW 3 72,958,592 (GRCm39) missense possibly damaging 0.89
R8843:Slitrk3 UTSW 3 72,956,164 (GRCm39) missense probably benign 0.04
R9140:Slitrk3 UTSW 3 72,957,792 (GRCm39) missense probably benign 0.02
R9451:Slitrk3 UTSW 3 72,958,616 (GRCm39) missense possibly damaging 0.83
R9511:Slitrk3 UTSW 3 72,958,272 (GRCm39) missense possibly damaging 0.46
R9575:Slitrk3 UTSW 3 72,956,127 (GRCm39) missense probably benign 0.00
R9589:Slitrk3 UTSW 3 72,957,981 (GRCm39) missense probably benign 0.24
R9603:Slitrk3 UTSW 3 72,958,649 (GRCm39) missense probably benign 0.00
X0022:Slitrk3 UTSW 3 72,957,599 (GRCm39) missense probably damaging 1.00
Z1176:Slitrk3 UTSW 3 72,956,103 (GRCm39) missense probably benign 0.09
Z1177:Slitrk3 UTSW 3 72,956,475 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GTCTAGTAGCAGACTGCCAC -3'
(R):5'- CCCCATCTATAAGCCTCGAGAG -3'

Sequencing Primer
(F):5'- TAGCAGACTGCCACCACCAC -3'
(R):5'- GGAGGAAGAAGTGGCTGCC -3'
Posted On 2015-02-05