Incidental Mutation 'R2939:Dagla'
ID 264608
Institutional Source Beutler Lab
Gene Symbol Dagla
Ensembl Gene ENSMUSG00000035735
Gene Name diacylglycerol lipase, alpha
Synonyms Nsddr
MMRRC Submission 040516-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2939 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 10222629-10282241 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 10233728 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Cysteine at position 382 (F382C)
Ref Sequence ENSEMBL: ENSMUSP00000046358 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039327] [ENSMUST00000125567]
AlphaFold Q6WQJ1
Predicted Effect probably damaging
Transcript: ENSMUST00000039327
AA Change: F382C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000046358
Gene: ENSMUSG00000035735
AA Change: F382C

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
transmembrane domain 63 85 N/A INTRINSIC
transmembrane domain 97 119 N/A INTRINSIC
transmembrane domain 134 156 N/A INTRINSIC
Pfam:Lipase_3 394 533 1.3e-12 PFAM
low complexity region 616 625 N/A INTRINSIC
low complexity region 699 717 N/A INTRINSIC
low complexity region 793 810 N/A INTRINSIC
low complexity region 878 896 N/A INTRINSIC
low complexity region 980 1002 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000125567
SMART Domains Protein: ENSMUSP00000138702
Gene: ENSMUSG00000035735

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
transmembrane domain 63 85 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156361
Meta Mutation Damage Score 0.9246 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.6%
Validation Efficiency 98% (62/63)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.[provided by RefSeq, Nov 2010]
PHENOTYPE: Mice homozygous for null mutations have decreased body weight, adult neuronal proliferation, and nervous system endocannaboid levels and abnormal inhibitory postsynaptic currents. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl11 T C 9: 107,808,409 (GRCm39) Y911H possibly damaging Het
Arhgef26 A C 3: 62,288,331 (GRCm39) K467T possibly damaging Het
Armcx6 A T X: 133,650,625 (GRCm39) W69R probably damaging Het
Asl T C 5: 130,042,245 (GRCm39) Y277C probably damaging Het
Atm T C 9: 53,406,011 (GRCm39) Y1219C probably damaging Het
Azin2 C T 4: 128,828,397 (GRCm39) C270Y probably benign Het
Brsk1 A T 7: 4,711,139 (GRCm39) I545F possibly damaging Het
Carm1 C A 9: 21,490,692 (GRCm39) probably null Het
Cfap410 A G 10: 77,817,507 (GRCm39) N78S probably benign Het
Cfap69 G A 5: 5,694,432 (GRCm39) A143V probably damaging Het
Cldn14 T C 16: 93,716,192 (GRCm39) K218R probably damaging Het
Col5a3 T C 9: 20,706,954 (GRCm39) K714R unknown Het
Crybg2 A G 4: 133,809,745 (GRCm39) H1517R possibly damaging Het
Dixdc1 G A 9: 50,622,259 (GRCm39) A25V probably damaging Het
Dock6 A G 9: 21,750,496 (GRCm39) F473L possibly damaging Het
Eif5 T C 12: 111,506,713 (GRCm39) C102R probably damaging Het
Faiml A G 9: 99,114,527 (GRCm39) C121R probably damaging Het
Fhdc1 A G 3: 84,364,577 (GRCm39) V223A possibly damaging Het
Garin4 T C 1: 190,896,103 (GRCm39) D180G possibly damaging Het
Gpatch8 A G 11: 102,399,010 (GRCm39) V74A unknown Het
Haghl A G 17: 26,004,060 (GRCm39) V8A possibly damaging Het
Ksr1 A G 11: 78,936,007 (GRCm39) probably null Het
Lama5 A C 2: 179,840,747 (GRCm39) Y584D probably damaging Het
Lgi4 C T 7: 30,767,253 (GRCm39) R427* probably null Het
Lrriq1 T A 10: 102,980,750 (GRCm39) S1462C probably damaging Het
Map3k4 C T 17: 12,480,157 (GRCm39) E682K probably damaging Het
Myo9b G A 8: 71,786,981 (GRCm39) R721Q probably benign Het
Nherf1 C T 11: 115,071,270 (GRCm39) R335C probably damaging Het
Nmnat2 C A 1: 152,950,474 (GRCm39) S53Y probably damaging Het
Or8b12i C A 9: 20,082,061 (GRCm39) G269W probably benign Het
Or8g34 G A 9: 39,373,226 (GRCm39) M166I probably benign Het
Pcsk7 C T 9: 45,827,322 (GRCm39) A363V probably damaging Het
Pdrg1 C T 2: 152,854,355 (GRCm39) G62R probably damaging Het
Pdzd7 A G 19: 45,033,862 (GRCm39) I74T possibly damaging Het
Plcb4 T C 2: 135,781,123 (GRCm39) probably benign Het
Pramel28 A G 4: 143,693,247 (GRCm39) V77A probably benign Het
Rnf25 A G 1: 74,635,047 (GRCm39) V135A possibly damaging Het
Rph3a A G 5: 121,118,212 (GRCm39) probably benign Het
Rsf1 CG CGACGGCGGTG 7: 97,229,115 (GRCm39) probably benign Het
Senp6 G A 9: 80,051,124 (GRCm39) A1134T probably benign Het
Slc1a6 G T 10: 78,650,448 (GRCm39) *562L probably null Het
Slc26a6 G A 9: 108,734,236 (GRCm39) V206I probably benign Het
Slc45a3 A G 1: 131,905,637 (GRCm39) E206G probably damaging Het
Smc1a T A X: 150,816,695 (GRCm39) Y516N probably damaging Het
Smpd3 A G 8: 106,984,039 (GRCm39) V560A probably benign Het
Spata31g1 A G 4: 42,972,946 (GRCm39) K760E probably benign Het
Ssc4d T C 5: 135,994,578 (GRCm39) T51A possibly damaging Het
Suco A G 1: 161,676,220 (GRCm39) I386T probably damaging Het
Tecta A T 9: 42,289,290 (GRCm39) M425K possibly damaging Het
Tmprss11e G A 5: 86,869,266 (GRCm39) R96W probably damaging Het
Trim63 T C 4: 134,050,308 (GRCm39) probably benign Het
Trpv1 A G 11: 73,145,675 (GRCm39) K403R probably damaging Het
Ttc39d A G 17: 80,524,982 (GRCm39) Y547C probably damaging Het
Unc79 C T 12: 102,957,684 (GRCm39) T33I probably damaging Het
Usp47 G A 7: 111,681,743 (GRCm39) S518N probably damaging Het
Vmn2r22 T A 6: 123,614,594 (GRCm39) D332V probably damaging Het
Vmn2r55 A G 7: 12,385,832 (GRCm39) L716P probably damaging Het
Zfp558 T C 9: 18,367,924 (GRCm39) N288S possibly damaging Het
Other mutations in Dagla
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01484:Dagla APN 19 10,225,884 (GRCm39) missense possibly damaging 0.51
IGL01625:Dagla APN 19 10,228,566 (GRCm39) splice site probably benign
IGL01697:Dagla APN 19 10,248,562 (GRCm39) missense probably benign 0.01
IGL01940:Dagla APN 19 10,229,535 (GRCm39) missense probably benign
IGL02330:Dagla APN 19 10,225,386 (GRCm39) missense probably damaging 1.00
blondie UTSW 19 10,248,465 (GRCm39) missense probably damaging 1.00
dagwood UTSW 19 10,247,079 (GRCm39) critical splice donor site probably null
PIT4480001:Dagla UTSW 19 10,238,022 (GRCm39) missense probably benign 0.02
R0541:Dagla UTSW 19 10,232,170 (GRCm39) critical splice donor site probably null
R0610:Dagla UTSW 19 10,248,922 (GRCm39) missense probably damaging 1.00
R0638:Dagla UTSW 19 10,232,247 (GRCm39) missense probably damaging 0.97
R0653:Dagla UTSW 19 10,225,789 (GRCm39) missense probably damaging 1.00
R1675:Dagla UTSW 19 10,246,687 (GRCm39) missense probably benign 0.00
R1822:Dagla UTSW 19 10,240,550 (GRCm39) missense possibly damaging 0.94
R1830:Dagla UTSW 19 10,248,378 (GRCm39) missense probably benign 0.44
R2303:Dagla UTSW 19 10,229,467 (GRCm39) missense probably damaging 1.00
R2568:Dagla UTSW 19 10,225,516 (GRCm39) missense probably benign
R2879:Dagla UTSW 19 10,248,448 (GRCm39) missense possibly damaging 0.93
R2902:Dagla UTSW 19 10,225,467 (GRCm39) missense probably damaging 0.99
R3771:Dagla UTSW 19 10,225,831 (GRCm39) missense possibly damaging 0.89
R4176:Dagla UTSW 19 10,240,461 (GRCm39) missense probably damaging 1.00
R4255:Dagla UTSW 19 10,234,316 (GRCm39) nonsense probably null
R4519:Dagla UTSW 19 10,247,096 (GRCm39) missense probably damaging 1.00
R4584:Dagla UTSW 19 10,248,373 (GRCm39) missense probably damaging 1.00
R4586:Dagla UTSW 19 10,248,373 (GRCm39) missense probably damaging 1.00
R4614:Dagla UTSW 19 10,225,641 (GRCm39) missense probably damaging 1.00
R4751:Dagla UTSW 19 10,227,758 (GRCm39) missense probably benign 0.00
R4933:Dagla UTSW 19 10,247,079 (GRCm39) critical splice donor site probably null
R5844:Dagla UTSW 19 10,248,489 (GRCm39) missense probably damaging 1.00
R5858:Dagla UTSW 19 10,232,332 (GRCm39) intron probably benign
R5958:Dagla UTSW 19 10,225,788 (GRCm39) missense probably damaging 1.00
R6628:Dagla UTSW 19 10,240,591 (GRCm39) missense probably damaging 1.00
R6799:Dagla UTSW 19 10,234,214 (GRCm39) missense probably damaging 1.00
R7072:Dagla UTSW 19 10,233,659 (GRCm39) critical splice donor site probably null
R7253:Dagla UTSW 19 10,239,945 (GRCm39) splice site probably null
R7451:Dagla UTSW 19 10,230,719 (GRCm39) missense probably damaging 1.00
R7654:Dagla UTSW 19 10,225,570 (GRCm39) missense probably benign 0.01
R7941:Dagla UTSW 19 10,248,867 (GRCm39) missense probably damaging 0.99
R7980:Dagla UTSW 19 10,229,406 (GRCm39) missense possibly damaging 0.82
R8293:Dagla UTSW 19 10,229,401 (GRCm39) critical splice donor site probably null
R8327:Dagla UTSW 19 10,228,451 (GRCm39) missense probably benign 0.11
R8442:Dagla UTSW 19 10,248,883 (GRCm39) missense probably damaging 0.99
R8442:Dagla UTSW 19 10,240,456 (GRCm39) critical splice donor site probably null
R8717:Dagla UTSW 19 10,225,587 (GRCm39) missense probably benign 0.03
R8728:Dagla UTSW 19 10,225,771 (GRCm39) missense probably damaging 1.00
R9053:Dagla UTSW 19 10,246,615 (GRCm39) missense probably damaging 1.00
R9179:Dagla UTSW 19 10,228,525 (GRCm39) missense possibly damaging 0.83
R9275:Dagla UTSW 19 10,232,220 (GRCm39) missense probably damaging 1.00
R9387:Dagla UTSW 19 10,248,465 (GRCm39) missense probably damaging 1.00
R9489:Dagla UTSW 19 10,233,053 (GRCm39) missense probably damaging 1.00
R9498:Dagla UTSW 19 10,232,218 (GRCm39) nonsense probably null
R9539:Dagla UTSW 19 10,228,429 (GRCm39) critical splice donor site probably null
R9605:Dagla UTSW 19 10,233,053 (GRCm39) missense probably damaging 1.00
X0021:Dagla UTSW 19 10,248,528 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TTGATACCTTGTGGCCCAAC -3'
(R):5'- AATGGAAGGGCTAGGTACCC -3'

Sequencing Primer
(F):5'- TGTCAGGTCAGTCAGGGCATC -3'
(R):5'- GCTAGGTACCCAAGAATCCTCAGTG -3'
Posted On 2015-02-05