Incidental Mutation 'R3031:Zfp663'
ID 264717
Institutional Source Beutler Lab
Gene Symbol Zfp663
Ensembl Gene ENSMUSG00000056824
Gene Name zinc finger protein 663
Synonyms LOC381405, Gm1008
MMRRC Submission 040547-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R3031 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 165193217-165210649 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 165195616 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 201 (L201*)
Ref Sequence ENSEMBL: ENSMUSP00000099374 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073062] [ENSMUST00000103085] [ENSMUST00000141140]
AlphaFold Q6NXM6
Predicted Effect probably null
Transcript: ENSMUST00000073062
AA Change: L201*
SMART Domains Protein: ENSMUSP00000072813
Gene: ENSMUSG00000056824
AA Change: L201*

DomainStartEndE-ValueType
KRAB 8 68 1.97e-31 SMART
ZnF_C2H2 205 227 3.47e1 SMART
ZnF_C2H2 472 494 2.4e-3 SMART
ZnF_C2H2 500 522 2.99e-4 SMART
ZnF_C2H2 528 550 2.43e-4 SMART
ZnF_C2H2 556 578 4.79e-3 SMART
ZnF_C2H2 584 606 3.95e-4 SMART
ZnF_C2H2 612 635 8.6e-5 SMART
Predicted Effect probably null
Transcript: ENSMUST00000103085
AA Change: L201*
SMART Domains Protein: ENSMUSP00000099374
Gene: ENSMUSG00000056824
AA Change: L201*

DomainStartEndE-ValueType
KRAB 8 68 1.97e-31 SMART
ZnF_C2H2 205 227 3.47e1 SMART
ZnF_C2H2 472 494 2.4e-3 SMART
ZnF_C2H2 500 522 2.99e-4 SMART
ZnF_C2H2 528 550 2.43e-4 SMART
ZnF_C2H2 556 578 4.79e-3 SMART
ZnF_C2H2 584 606 3.95e-4 SMART
ZnF_C2H2 612 635 8.6e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136482
Predicted Effect probably benign
Transcript: ENSMUST00000141140
SMART Domains Protein: ENSMUSP00000115254
Gene: ENSMUSG00000056824

DomainStartEndE-ValueType
KRAB 8 68 1.97e-31 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc5 C A 16: 20,193,863 (GRCm39) V753L probably damaging Het
Ap3b1 T C 13: 94,702,151 (GRCm39) L1068P unknown Het
Cacna1h C A 17: 25,652,108 (GRCm39) R12L probably damaging Het
Cbln4 A G 2: 171,884,100 (GRCm39) V40A probably damaging Het
Ccdc170 T C 10: 4,468,931 (GRCm39) S160P probably damaging Het
Cdc37 T C 9: 21,054,487 (GRCm39) E46G possibly damaging Het
Cltc T C 11: 86,621,158 (GRCm39) H287R probably damaging Het
Dsg1a A T 18: 20,473,549 (GRCm39) D874V probably damaging Het
Gjd4 G T 18: 9,280,811 (GRCm39) S89* probably null Het
Gkn3 C T 6: 87,360,507 (GRCm39) A163T probably damaging Het
Hydin A G 8: 111,329,848 (GRCm39) R4861G possibly damaging Het
Kcnh8 GAGACCAACGAGCAGCTGATGCTTCAGA GAGA 17: 53,032,934 (GRCm39) 74 probably benign Het
Lipe T C 7: 25,084,320 (GRCm39) E588G possibly damaging Het
Mael T C 1: 166,032,375 (GRCm39) D328G probably damaging Het
Mboat7 A G 7: 3,681,687 (GRCm39) V398A probably benign Het
Slc35e1 A G 8: 73,238,735 (GRCm39) W258R probably benign Het
Slc9a8 A G 2: 167,293,201 (GRCm39) D183G probably damaging Het
Sorcs1 G A 19: 50,213,613 (GRCm39) R705C probably damaging Het
Sult3a1 G A 10: 33,753,345 (GRCm39) D214N possibly damaging Het
Traf3ip1 T C 1: 91,447,822 (GRCm39) V433A probably damaging Het
Ubxn7 T A 16: 32,194,125 (GRCm39) D232E probably benign Het
Upf1 C T 8: 70,791,110 (GRCm39) R544H probably damaging Het
Vps13c T C 9: 67,831,052 (GRCm39) S1561P probably benign Het
Wdr48 T C 9: 119,753,176 (GRCm39) V593A probably benign Het
Zfp58 A G 13: 67,640,231 (GRCm39) F87L probably benign Het
Other mutations in Zfp663
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00720:Zfp663 APN 2 165,194,525 (GRCm39) missense probably damaging 1.00
IGL01382:Zfp663 APN 2 165,200,935 (GRCm39) missense probably damaging 1.00
IGL02007:Zfp663 APN 2 165,200,993 (GRCm39) missense probably benign 0.12
IGL02164:Zfp663 APN 2 165,200,968 (GRCm39) nonsense probably null
IGL02506:Zfp663 APN 2 165,195,871 (GRCm39) missense probably benign 0.35
IGL03173:Zfp663 APN 2 165,194,419 (GRCm39) missense probably damaging 0.99
R0735:Zfp663 UTSW 2 165,200,995 (GRCm39) missense probably damaging 0.97
R1395:Zfp663 UTSW 2 165,194,492 (GRCm39) missense probably damaging 1.00
R1402:Zfp663 UTSW 2 165,195,890 (GRCm39) missense probably benign 0.14
R1402:Zfp663 UTSW 2 165,195,890 (GRCm39) missense probably benign 0.14
R1503:Zfp663 UTSW 2 165,194,573 (GRCm39) missense probably damaging 0.99
R1587:Zfp663 UTSW 2 165,195,437 (GRCm39) missense probably benign
R1854:Zfp663 UTSW 2 165,195,211 (GRCm39) missense probably benign 0.18
R1867:Zfp663 UTSW 2 165,194,651 (GRCm39) missense possibly damaging 0.74
R4643:Zfp663 UTSW 2 165,194,925 (GRCm39) missense probably benign 0.24
R4691:Zfp663 UTSW 2 165,201,050 (GRCm39) intron probably benign
R4977:Zfp663 UTSW 2 165,195,731 (GRCm39) missense probably damaging 0.97
R5135:Zfp663 UTSW 2 165,195,590 (GRCm39) missense possibly damaging 0.95
R5151:Zfp663 UTSW 2 165,195,113 (GRCm39) missense probably benign 0.00
R5639:Zfp663 UTSW 2 165,194,929 (GRCm39) missense probably benign 0.03
R5763:Zfp663 UTSW 2 165,200,355 (GRCm39) nonsense probably null
R6776:Zfp663 UTSW 2 165,200,935 (GRCm39) missense probably damaging 1.00
R6929:Zfp663 UTSW 2 165,195,178 (GRCm39) missense probably benign
R6998:Zfp663 UTSW 2 165,195,922 (GRCm39) missense possibly damaging 0.74
R7035:Zfp663 UTSW 2 165,195,023 (GRCm39) missense probably benign 0.36
R7169:Zfp663 UTSW 2 165,194,359 (GRCm39) missense probably benign 0.00
R7529:Zfp663 UTSW 2 165,194,728 (GRCm39) missense probably damaging 1.00
R7790:Zfp663 UTSW 2 165,194,453 (GRCm39) missense probably damaging 1.00
R8087:Zfp663 UTSW 2 165,195,679 (GRCm39) missense probably benign 0.20
R8715:Zfp663 UTSW 2 165,194,644 (GRCm39) missense probably damaging 1.00
R8934:Zfp663 UTSW 2 165,194,714 (GRCm39) missense probably damaging 1.00
R8966:Zfp663 UTSW 2 165,194,958 (GRCm39) missense probably damaging 1.00
R9257:Zfp663 UTSW 2 165,195,974 (GRCm39) missense probably benign 0.00
R9278:Zfp663 UTSW 2 165,202,010 (GRCm39) critical splice acceptor site probably null
R9524:Zfp663 UTSW 2 165,195,607 (GRCm39) missense probably damaging 0.99
RF004:Zfp663 UTSW 2 165,200,363 (GRCm39) missense probably benign 0.00
Z1177:Zfp663 UTSW 2 165,195,033 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CCATGTTGGCTAGCCTCTTG -3'
(R):5'- CAGAAGTGTTGCTCAATGGAAGC -3'

Sequencing Primer
(F):5'- GCTTCTTCCTTTCACGTAGGG -3'
(R):5'- TTGCTCAATGGAAGCAAGCTTG -3'
Posted On 2015-02-05