Incidental Mutation 'R3031:Zfp58'
ID 264733
Institutional Source Beutler Lab
Gene Symbol Zfp58
Ensembl Gene ENSMUSG00000071291
Gene Name zinc finger protein 58
Synonyms Mfg1, Zfp817, A530094I17Rik, Mfg-1
MMRRC Submission 040547-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # R3031 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 67638286-67648641 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 67640231 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 87 (F87L)
Ref Sequence ENSEMBL: ENSMUSP00000132285 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076123] [ENSMUST00000091523] [ENSMUST00000163534] [ENSMUST00000167914] [ENSMUST00000171518]
AlphaFold P16372
Predicted Effect probably benign
Transcript: ENSMUST00000076123
AA Change: F87L

PolyPhen 2 Score 0.060 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000075487
Gene: ENSMUSG00000071291
AA Change: F87L

DomainStartEndE-ValueType
KRAB 2 62 2.19e-29 SMART
ZnF_C2H2 106 128 4.01e-5 SMART
ZnF_C2H2 134 156 9.73e-4 SMART
ZnF_C2H2 162 184 5.67e-5 SMART
ZnF_C2H2 190 212 3.21e-4 SMART
ZnF_C2H2 218 240 2.57e-3 SMART
ZnF_C2H2 246 268 2.91e-2 SMART
ZnF_C2H2 274 296 9.73e-4 SMART
ZnF_C2H2 302 324 6.23e-2 SMART
ZnF_C2H2 330 352 1.03e-2 SMART
ZnF_C2H2 358 380 1.45e-2 SMART
ZnF_C2H2 386 408 2.99e-4 SMART
ZnF_C2H2 410 432 4.87e-4 SMART
ZnF_C2H2 438 460 2.75e-3 SMART
ZnF_C2H2 466 488 1.58e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000091523
AA Change: F87L

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000089108
Gene: ENSMUSG00000071291
AA Change: F87L

DomainStartEndE-ValueType
KRAB 2 62 2.19e-29 SMART
ZnF_C2H2 106 128 4.01e-5 SMART
ZnF_C2H2 134 156 9.73e-4 SMART
ZnF_C2H2 162 184 5.67e-5 SMART
ZnF_C2H2 190 212 3.21e-4 SMART
ZnF_C2H2 218 240 2.57e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000163534
AA Change: F87L

PolyPhen 2 Score 0.037 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000129177
Gene: ENSMUSG00000071291
AA Change: F87L

DomainStartEndE-ValueType
KRAB 2 62 2.19e-29 SMART
ZnF_C2H2 106 128 4.01e-5 SMART
ZnF_C2H2 134 156 9.73e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000167914
SMART Domains Protein: ENSMUSP00000137830
Gene: ENSMUSG00000097565

DomainStartEndE-ValueType
KRAB 5 65 4.41e-34 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000171518
AA Change: F87L

PolyPhen 2 Score 0.060 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000132285
Gene: ENSMUSG00000071291
AA Change: F87L

DomainStartEndE-ValueType
KRAB 2 62 2.19e-29 SMART
ZnF_C2H2 106 128 4.01e-5 SMART
ZnF_C2H2 134 156 9.73e-4 SMART
ZnF_C2H2 162 184 5.67e-5 SMART
ZnF_C2H2 190 212 3.21e-4 SMART
ZnF_C2H2 218 240 2.57e-3 SMART
ZnF_C2H2 246 268 2.91e-2 SMART
ZnF_C2H2 274 296 9.73e-4 SMART
ZnF_C2H2 302 324 6.23e-2 SMART
ZnF_C2H2 330 352 1.03e-2 SMART
ZnF_C2H2 358 380 1.45e-2 SMART
ZnF_C2H2 386 408 2.99e-4 SMART
ZnF_C2H2 410 432 4.87e-4 SMART
ZnF_C2H2 438 460 2.75e-3 SMART
ZnF_C2H2 466 488 1.58e-3 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc5 C A 16: 20,193,863 (GRCm39) V753L probably damaging Het
Ap3b1 T C 13: 94,702,151 (GRCm39) L1068P unknown Het
Cacna1h C A 17: 25,652,108 (GRCm39) R12L probably damaging Het
Cbln4 A G 2: 171,884,100 (GRCm39) V40A probably damaging Het
Ccdc170 T C 10: 4,468,931 (GRCm39) S160P probably damaging Het
Cdc37 T C 9: 21,054,487 (GRCm39) E46G possibly damaging Het
Cltc T C 11: 86,621,158 (GRCm39) H287R probably damaging Het
Dsg1a A T 18: 20,473,549 (GRCm39) D874V probably damaging Het
Gjd4 G T 18: 9,280,811 (GRCm39) S89* probably null Het
Gkn3 C T 6: 87,360,507 (GRCm39) A163T probably damaging Het
Hydin A G 8: 111,329,848 (GRCm39) R4861G possibly damaging Het
Kcnh8 GAGACCAACGAGCAGCTGATGCTTCAGA GAGA 17: 53,032,934 (GRCm39) 74 probably benign Het
Lipe T C 7: 25,084,320 (GRCm39) E588G possibly damaging Het
Mael T C 1: 166,032,375 (GRCm39) D328G probably damaging Het
Mboat7 A G 7: 3,681,687 (GRCm39) V398A probably benign Het
Slc35e1 A G 8: 73,238,735 (GRCm39) W258R probably benign Het
Slc9a8 A G 2: 167,293,201 (GRCm39) D183G probably damaging Het
Sorcs1 G A 19: 50,213,613 (GRCm39) R705C probably damaging Het
Sult3a1 G A 10: 33,753,345 (GRCm39) D214N possibly damaging Het
Traf3ip1 T C 1: 91,447,822 (GRCm39) V433A probably damaging Het
Ubxn7 T A 16: 32,194,125 (GRCm39) D232E probably benign Het
Upf1 C T 8: 70,791,110 (GRCm39) R544H probably damaging Het
Vps13c T C 9: 67,831,052 (GRCm39) S1561P probably benign Het
Wdr48 T C 9: 119,753,176 (GRCm39) V593A probably benign Het
Zfp663 A T 2: 165,195,616 (GRCm39) L201* probably null Het
Other mutations in Zfp58
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00091:Zfp58 APN 13 67,639,114 (GRCm39) missense probably benign 0.29
IGL02618:Zfp58 APN 13 67,639,475 (GRCm39) missense possibly damaging 0.92
IGL03188:Zfp58 APN 13 67,639,528 (GRCm39) missense probably benign 0.03
R0535:Zfp58 UTSW 13 67,640,201 (GRCm39) nonsense probably null
R1470:Zfp58 UTSW 13 67,640,144 (GRCm39) missense possibly damaging 0.71
R1470:Zfp58 UTSW 13 67,640,144 (GRCm39) missense possibly damaging 0.71
R1750:Zfp58 UTSW 13 67,639,598 (GRCm39) nonsense probably null
R1862:Zfp58 UTSW 13 67,639,307 (GRCm39) missense probably damaging 1.00
R2697:Zfp58 UTSW 13 67,639,124 (GRCm39) missense probably damaging 1.00
R3033:Zfp58 UTSW 13 67,639,741 (GRCm39) missense probably damaging 1.00
R4200:Zfp58 UTSW 13 67,639,440 (GRCm39) missense probably benign 0.25
R5827:Zfp58 UTSW 13 67,639,412 (GRCm39) missense probably damaging 0.99
R6723:Zfp58 UTSW 13 67,642,192 (GRCm39) missense probably damaging 1.00
R7230:Zfp58 UTSW 13 67,640,082 (GRCm39) nonsense probably null
R7890:Zfp58 UTSW 13 67,640,114 (GRCm39) missense possibly damaging 0.95
R9189:Zfp58 UTSW 13 67,640,035 (GRCm39) missense possibly damaging 0.93
R9338:Zfp58 UTSW 13 67,639,394 (GRCm39) missense probably benign 0.43
R9477:Zfp58 UTSW 13 67,640,158 (GRCm39) missense probably damaging 1.00
R9587:Zfp58 UTSW 13 67,639,823 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GAAAGGCCTTACCACATTCTTC -3'
(R):5'- GTAGAAGCTTAGATTGTTTCCTCCTAC -3'

Sequencing Primer
(F):5'- ACCACATTCTTCACATTTGTAGGG -3'
(R):5'- TCATGCTAAATGAATACAGGGGTAG -3'
Posted On 2015-02-05