Incidental Mutation 'R3039:Dusp29'
| ID |
264905 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dusp29
|
| Ensembl Gene |
ENSMUSG00000063821 |
| Gene Name |
dual specificity phosphatase 29 |
| Synonyms |
Dupd1, EG435391 |
| MMRRC Submission |
040555-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.087)
|
| Stock # |
R3039 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
14 |
| Chromosomal Location |
21726605-21764644 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 21752975 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 57
(V57A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153223
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000073870]
[ENSMUST00000224735]
|
| AlphaFold |
Q8BK84 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000073870
AA Change: V57A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000073534
Gene: ENSMUSG00000063821
AA Change: V57A
| Domain | Start | End | E-Value | Type |
|---|
|
DSPc
|
53 |
198 |
4.9e-30 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000224735
AA Change: V57A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.1%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 15 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700069L16Rik |
T |
A |
5: 113,830,797 (GRCm39) |
K64N |
unknown |
Het |
| B4galt3 |
C |
A |
1: 171,101,613 (GRCm39) |
H196N |
probably damaging |
Het |
| Cap2 |
A |
G |
13: 46,793,317 (GRCm39) |
N228D |
probably benign |
Het |
| Cd300ld |
A |
G |
11: 114,877,003 (GRCm39) |
S143P |
probably benign |
Het |
| Cmya5 |
A |
G |
13: 93,228,758 (GRCm39) |
V2110A |
probably benign |
Het |
| Gpat3 |
T |
C |
5: 101,045,671 (GRCm39) |
S432P |
possibly damaging |
Het |
| Lgi4 |
C |
T |
7: 30,759,492 (GRCm39) |
A16V |
probably benign |
Het |
| Nsmce1 |
T |
C |
7: 125,070,328 (GRCm39) |
E161G |
probably damaging |
Het |
| Pdgfa |
A |
G |
5: 138,972,114 (GRCm39) |
V95A |
probably benign |
Het |
| Pes1 |
T |
C |
11: 3,925,547 (GRCm39) |
Y221H |
probably damaging |
Het |
| Phf19 |
T |
C |
2: 34,795,534 (GRCm39) |
E179G |
probably benign |
Het |
| Rpap2 |
G |
A |
5: 107,749,661 (GRCm39) |
V62I |
possibly damaging |
Het |
| Ush2a |
T |
C |
1: 188,643,744 (GRCm39) |
S4369P |
probably damaging |
Het |
| Wdr1 |
A |
G |
5: 38,687,428 (GRCm39) |
I201T |
possibly damaging |
Het |
| Zhx1 |
T |
C |
15: 57,916,647 (GRCm39) |
D533G |
possibly damaging |
Het |
|
| Other mutations in Dusp29 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02280:Dusp29
|
APN |
14 |
21,736,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02452:Dusp29
|
APN |
14 |
21,752,990 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02640:Dusp29
|
APN |
14 |
21,753,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1862:Dusp29
|
UTSW |
14 |
21,736,757 (GRCm39) |
missense |
probably benign |
0.11 |
|
R5240:Dusp29
|
UTSW |
14 |
21,727,091 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5352:Dusp29
|
UTSW |
14 |
21,727,091 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5354:Dusp29
|
UTSW |
14 |
21,727,091 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5355:Dusp29
|
UTSW |
14 |
21,727,091 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5356:Dusp29
|
UTSW |
14 |
21,727,091 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6125:Dusp29
|
UTSW |
14 |
21,736,758 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6943:Dusp29
|
UTSW |
14 |
21,727,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7134:Dusp29
|
UTSW |
14 |
21,727,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7206:Dusp29
|
UTSW |
14 |
21,727,102 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8322:Dusp29
|
UTSW |
14 |
21,752,950 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8896:Dusp29
|
UTSW |
14 |
21,736,763 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGTCTTAGGCTAGGCTTCCCC -3'
(R):5'- GCTCCAAAATGGCATCAGGAG -3'
Sequencing Primer
(F):5'- TCTGGGTCCTGAACAACCTTGAAG -3'
(R):5'- CATCAGGAGATACAAAGACAAGCGTC -3'
|
| Posted On |
2015-02-05 |
Incidental Mutation