Incidental Mutation 'R3056:Or8k3b'
ID 265165
Institutional Source Beutler Lab
Gene Symbol Or8k3b
Ensembl Gene ENSMUSG00000075174
Gene Name olfactory receptor family 8 subfamily K member 3B
Synonyms Olfr1087, GA_x6K02T2Q125-48182406-48181465, MOR188-5
MMRRC Submission 040565-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.186) question?
Stock # R3056 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 86520376-86521317 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 86520896 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Phenylalanine at position 141 (C141F)
Ref Sequence ENSEMBL: ENSMUSP00000149439 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099877] [ENSMUST00000214141]
AlphaFold Q7TR63
Predicted Effect possibly damaging
Transcript: ENSMUST00000099877
AA Change: C141F

PolyPhen 2 Score 0.908 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000097462
Gene: ENSMUSG00000075174
AA Change: C141F

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 5.5e-49 PFAM
Pfam:7tm_1 41 290 1.7e-20 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214141
AA Change: C141F

PolyPhen 2 Score 0.908 (Sensitivity: 0.81; Specificity: 0.94)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4fm4 A G 4: 144,401,268 (GRCm39) I72T probably benign Het
Abca1 A T 4: 53,127,626 (GRCm39) M131K probably benign Het
Agbl1 C T 7: 76,416,232 (GRCm39) T751M possibly damaging Het
Asb14 A G 14: 26,636,146 (GRCm39) I510V possibly damaging Het
Bard1 A G 1: 71,127,390 (GRCm39) V73A possibly damaging Het
C6 T C 15: 4,769,355 (GRCm39) I187T probably damaging Het
Catsper3 T C 13: 55,956,709 (GRCm39) S376P unknown Het
Ccdc150 A G 1: 54,328,001 (GRCm39) N361S possibly damaging Het
Cntn5 A G 9: 10,419,076 (GRCm39) L7P probably benign Het
Cplane1 T C 15: 8,280,491 (GRCm39) S2805P unknown Het
Cxcr6 A T 9: 123,639,529 (GRCm39) I177F probably damaging Het
Dnah7b A G 1: 46,307,869 (GRCm39) D3061G possibly damaging Het
Epas1 T C 17: 87,138,409 (GRCm39) F835S probably damaging Het
Fat3 C T 9: 15,871,792 (GRCm39) R3533H probably benign Het
Fxr1 A G 3: 34,103,333 (GRCm39) E221G probably damaging Het
Gpatch11 A G 17: 79,151,272 (GRCm39) T228A probably damaging Het
Greb1 G T 12: 16,738,592 (GRCm39) T1457K probably damaging Het
Ighm T A 12: 113,382,596 (GRCm39) probably benign Het
Ints12 G A 3: 132,815,126 (GRCm39) M444I possibly damaging Het
Lmx1b G A 2: 33,457,297 (GRCm39) Q168* probably null Het
Ltbp3 C A 19: 5,801,434 (GRCm39) N659K probably benign Het
Micos13 A G 17: 56,915,889 (GRCm39) F55S probably damaging Het
Mrpl20 G T 4: 155,888,329 (GRCm39) V43F possibly damaging Het
Nlgn1 T C 3: 25,487,860 (GRCm39) N825S possibly damaging Het
Or5d36 T A 2: 87,901,583 (GRCm39) T48S probably benign Het
Or5p67 A T 7: 107,922,757 (GRCm39) V42E possibly damaging Het
Pccb C T 9: 100,912,250 (GRCm39) R79Q probably damaging Het
Peg10 G A 6: 4,755,029 (GRCm39) R270H possibly damaging Het
Pttg1ip2 A T 5: 5,507,283 (GRCm39) probably null Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Slc4a4 T C 5: 89,373,807 (GRCm39) V971A probably damaging Het
Timm29 T C 9: 21,504,887 (GRCm39) M185T probably damaging Het
Tmem92 C T 11: 94,669,873 (GRCm39) C86Y probably benign Het
Tnfrsf8 C T 4: 145,011,895 (GRCm39) probably null Het
Tnks1bp1 T A 2: 84,900,344 (GRCm39) C1433* probably null Het
Utp14b T A 1: 78,642,442 (GRCm39) D113E possibly damaging Het
Vmn2r110 T A 17: 20,803,360 (GRCm39) Y405F probably damaging Het
Wiz A G 17: 32,576,671 (GRCm39) S628P probably benign Het
Xrcc4 T C 13: 90,210,196 (GRCm39) T83A probably benign Het
Other mutations in Or8k3b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01747:Or8k3b APN 2 86,521,045 (GRCm39) missense possibly damaging 0.90
IGL02300:Or8k3b APN 2 86,520,996 (GRCm39) missense probably benign 0.43
IGL03259:Or8k3b APN 2 86,520,894 (GRCm39) missense probably benign 0.00
IGL03404:Or8k3b APN 2 86,520,372 (GRCm39) utr 3 prime probably benign
R1430:Or8k3b UTSW 2 86,520,866 (GRCm39) missense possibly damaging 0.91
R1513:Or8k3b UTSW 2 86,521,141 (GRCm39) missense possibly damaging 0.60
R1529:Or8k3b UTSW 2 86,520,677 (GRCm39) missense possibly damaging 0.69
R1767:Or8k3b UTSW 2 86,520,728 (GRCm39) missense probably benign 0.01
R1869:Or8k3b UTSW 2 86,520,735 (GRCm39) missense probably damaging 0.98
R5002:Or8k3b UTSW 2 86,520,429 (GRCm39) missense possibly damaging 0.95
R7303:Or8k3b UTSW 2 86,521,166 (GRCm39) missense probably benign 0.05
R8335:Or8k3b UTSW 2 86,520,512 (GRCm39) missense probably benign 0.38
R9042:Or8k3b UTSW 2 86,521,139 (GRCm39) missense probably damaging 0.99
R9364:Or8k3b UTSW 2 86,520,575 (GRCm39) missense possibly damaging 0.66
X0063:Or8k3b UTSW 2 86,520,887 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CCGAGTTCATTCTGAGAATGGC -3'
(R):5'- AGCTGTGGGACCTAAGATGTTG -3'

Sequencing Primer
(F):5'- GTTCATTCTGAGAATGGCTATAAGG -3'
(R):5'- GGGACCTAAGATGTTGGTAAATTTTG -3'
Posted On 2015-02-05