Incidental Mutation 'R3076:Nrsn1'
ID 265231
Institutional Source Beutler Lab
Gene Symbol Nrsn1
Ensembl Gene ENSMUSG00000048978
Gene Name neurensin 1
Synonyms Vmp, Neuro-p24, Neurensin-1
MMRRC Submission 040566-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3076 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 25436022-25453979 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 25437542 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 129 (T129A)
Ref Sequence ENSEMBL: ENSMUSP00000128979 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057866] [ENSMUST00000167305]
AlphaFold P97799
Predicted Effect probably benign
Transcript: ENSMUST00000057866
AA Change: T129A

PolyPhen 2 Score 0.116 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000055048
Gene: ENSMUSG00000048978
AA Change: T129A

DomainStartEndE-ValueType
Pfam:Neurensin 24 154 2.3e-54 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156448
Predicted Effect probably benign
Transcript: ENSMUST00000167305
AA Change: T129A

PolyPhen 2 Score 0.116 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000128979
Gene: ENSMUSG00000048978
AA Change: T129A

DomainStartEndE-ValueType
Pfam:Neurensin 24 159 3.6e-57 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrd1 A T 5: 129,206,169 (GRCm39) I248F probably benign Het
Amigo2 C T 15: 97,143,315 (GRCm39) R369Q probably damaging Het
Aopep A C 13: 63,387,929 (GRCm39) D3A probably damaging Het
Arfgef3 T C 10: 18,479,278 (GRCm39) I1446V probably damaging Het
Ascc2 T A 11: 4,622,446 (GRCm39) L504Q probably damaging Het
Atp1a3 A G 7: 24,679,498 (GRCm39) V932A possibly damaging Het
Cabcoco1 T G 10: 68,361,475 (GRCm39) Y8S possibly damaging Het
Cct8 A G 16: 87,285,765 (GRCm39) V231A possibly damaging Het
Col18a1 T C 10: 76,924,762 (GRCm39) K9R possibly damaging Het
Dlgap3 A G 4: 127,089,499 (GRCm39) Y365C probably damaging Het
Dock3 T C 9: 106,818,725 (GRCm39) probably null Het
Gtf3c4 A T 2: 28,725,165 (GRCm39) V189E possibly damaging Het
Khdc3 C A 9: 73,010,212 (GRCm39) F89L probably damaging Het
Kif14 T G 1: 136,447,383 (GRCm39) I1396S possibly damaging Het
Magi1 T C 6: 93,734,668 (GRCm39) Q393R possibly damaging Het
Med28 A G 5: 45,679,820 (GRCm39) T68A possibly damaging Het
Meis1 A T 11: 18,961,254 (GRCm39) N206K probably benign Het
Mnt G C 11: 74,733,936 (GRCm39) probably benign Het
Mrgpre C T 7: 143,335,033 (GRCm39) A157T probably benign Het
Mtpn C T 6: 35,498,879 (GRCm39) V76I possibly damaging Het
Nbeal2 A T 9: 110,460,768 (GRCm39) W1702R probably damaging Het
Nhsl2 C T X: 101,121,201 (GRCm39) R62W probably damaging Het
Npr2 T A 4: 43,640,182 (GRCm39) Y306N probably damaging Het
Nrxn3 T G 12: 89,227,186 (GRCm39) C274G probably damaging Het
Nyap2 T C 1: 81,219,686 (GRCm39) probably null Het
Or1e29 G A 11: 73,667,466 (GRCm39) P229L possibly damaging Het
Or1o11 T C 17: 37,756,375 (GRCm39) probably benign Het
Phldb2 T C 16: 45,645,373 (GRCm39) T403A probably benign Het
Plaa T C 4: 94,458,042 (GRCm39) I643V probably benign Het
Ptprb T C 10: 116,179,931 (GRCm39) S1450P probably damaging Het
Sh2d2a T C 3: 87,759,477 (GRCm39) I296T probably benign Het
Shtn1 T C 19: 58,983,518 (GRCm39) E471G probably damaging Het
St7 T G 6: 17,846,237 (GRCm39) Y163* probably null Het
Svil T C 18: 5,116,055 (GRCm39) S1623P probably damaging Het
Ugcg T G 4: 59,213,922 (GRCm39) V168G probably damaging Het
Vmn1r223 G A 13: 23,434,335 (GRCm39) A310T probably benign Het
Zfp647 A T 15: 76,802,209 (GRCm39) M1K probably null Het
Other mutations in Nrsn1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02839:Nrsn1 APN 13 25,437,527 (GRCm39) missense probably damaging 0.97
IGL03127:Nrsn1 APN 13 25,437,700 (GRCm39) missense probably damaging 0.97
R0549:Nrsn1 UTSW 13 25,446,241 (GRCm39) missense probably benign 0.01
R4804:Nrsn1 UTSW 13 25,437,580 (GRCm39) missense probably benign 0.40
R6020:Nrsn1 UTSW 13 25,437,355 (GRCm39) missense probably damaging 1.00
R7094:Nrsn1 UTSW 13 25,437,724 (GRCm39) missense possibly damaging 0.85
R7116:Nrsn1 UTSW 13 25,437,388 (GRCm39) missense probably damaging 0.99
R7226:Nrsn1 UTSW 13 25,437,451 (GRCm39) missense probably damaging 0.99
R7859:Nrsn1 UTSW 13 25,446,254 (GRCm39) missense probably damaging 1.00
R8481:Nrsn1 UTSW 13 25,437,598 (GRCm39) missense probably damaging 1.00
R9102:Nrsn1 UTSW 13 25,437,517 (GRCm39) missense probably benign
R9753:Nrsn1 UTSW 13 25,437,563 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- GGCCTGAGGTGACAAATGTTTC -3'
(R):5'- AGGCACTGTCTTTGTGATTCTC -3'

Sequencing Primer
(F):5'- AGAGGCTGCACATTCTGAACTCTG -3'
(R):5'- TGTGATTCTCGGACTAACTGTC -3'
Posted On 2015-02-05