Incidental Mutation 'R3079:Vmn1r222'
| ID |
265350 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r222
|
| Ensembl Gene |
ENSMUSG00000061022 |
| Gene Name |
vomeronasal 1 receptor 222 |
| Synonyms |
V1rh16 |
| MMRRC Submission |
040569-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.099)
|
| Stock # |
R3079 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
13 |
| Chromosomal Location |
23416285-23417211 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 23416631 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Threonine
at position 194
(M194T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000076365
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000077116]
|
| AlphaFold |
Q8R269 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000077116
AA Change: M194T
PolyPhen 2
Score 0.745 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000076365
Gene: ENSMUSG00000061022
AA Change: M194T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
32 |
297 |
3.6e-39 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000225143
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 43 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aaas |
A |
T |
15: 102,248,879 (GRCm39) |
L168H |
probably damaging |
Het |
| Abca15 |
T |
C |
7: 119,984,392 (GRCm39) |
W1158R |
probably damaging |
Het |
| Anks4b |
A |
T |
7: 119,781,146 (GRCm39) |
D59V |
probably damaging |
Het |
| Aqp11 |
A |
T |
7: 97,386,795 (GRCm39) |
C134S |
probably benign |
Het |
| Arhgap35 |
A |
G |
7: 16,296,501 (GRCm39) |
Y855H |
probably damaging |
Het |
| Ces1c |
A |
C |
8: 93,846,975 (GRCm39) |
L93R |
probably damaging |
Het |
| Cit |
A |
G |
5: 116,063,545 (GRCm39) |
D462G |
probably damaging |
Het |
| Col6a6 |
T |
C |
9: 105,631,422 (GRCm39) |
R1494G |
probably benign |
Het |
| Edc4 |
T |
C |
8: 106,611,750 (GRCm39) |
S109P |
possibly damaging |
Het |
| Elp4 |
T |
C |
2: 105,639,790 (GRCm39) |
K130E |
possibly damaging |
Het |
| Gemin5 |
A |
T |
11: 58,036,345 (GRCm39) |
V666E |
probably damaging |
Het |
| Hba-x |
A |
G |
11: 32,227,616 (GRCm39) |
D62G |
probably damaging |
Het |
| Hnrnpul1 |
A |
T |
7: 25,432,540 (GRCm39) |
Y474* |
probably null |
Het |
| Ighv5-6 |
T |
A |
12: 113,589,237 (GRCm39) |
D81V |
probably damaging |
Het |
| Krt1 |
C |
T |
15: 101,754,622 (GRCm39) |
G543S |
unknown |
Het |
| Mbtps1 |
A |
G |
8: 120,257,944 (GRCm39) |
V431A |
probably benign |
Het |
| Mbtps1 |
T |
C |
8: 120,265,602 (GRCm39) |
D315G |
probably damaging |
Het |
| Mrc2 |
T |
C |
11: 105,227,539 (GRCm39) |
S591P |
probably damaging |
Het |
| Msh5 |
T |
C |
17: 35,265,208 (GRCm39) |
E48G |
probably benign |
Het |
| Mybpc2 |
T |
C |
7: 44,155,505 (GRCm39) |
D916G |
probably damaging |
Het |
| Nebl |
A |
G |
2: 17,381,462 (GRCm39) |
V738A |
possibly damaging |
Het |
| Nlrp1b |
T |
C |
11: 71,108,794 (GRCm39) |
R236G |
probably benign |
Het |
| Obsl1 |
G |
T |
1: 75,467,467 (GRCm39) |
R1436S |
probably damaging |
Het |
| Or14j4 |
T |
C |
17: 37,921,169 (GRCm39) |
T158A |
probably benign |
Het |
| Or51a7 |
C |
T |
7: 102,622,254 (GRCm39) |
|
probably null |
Het |
| Padi2 |
T |
C |
4: 140,677,189 (GRCm39) |
V659A |
probably damaging |
Het |
| Pnpla6 |
T |
G |
8: 3,591,512 (GRCm39) |
S1169A |
probably benign |
Het |
| Pramel30 |
T |
G |
4: 144,058,098 (GRCm39) |
L235R |
probably damaging |
Het |
| Prl6a1 |
A |
G |
13: 27,502,983 (GRCm39) |
D193G |
possibly damaging |
Het |
| Rce1 |
G |
T |
19: 4,674,750 (GRCm39) |
C138* |
probably null |
Het |
| Shoc1 |
G |
T |
4: 59,047,848 (GRCm39) |
T1257N |
possibly damaging |
Het |
| Shroom3 |
G |
T |
5: 93,090,945 (GRCm39) |
V1151F |
probably damaging |
Het |
| Skint2 |
A |
G |
4: 112,496,870 (GRCm39) |
T259A |
probably benign |
Het |
| Slc66a1 |
G |
T |
4: 139,033,829 (GRCm39) |
A30D |
probably damaging |
Het |
| Slco5a1 |
C |
T |
1: 12,949,486 (GRCm39) |
G635S |
probably damaging |
Het |
| Slfn1 |
T |
C |
11: 83,011,986 (GRCm39) |
V34A |
probably benign |
Het |
| Syt4 |
A |
G |
18: 31,574,738 (GRCm39) |
V293A |
probably benign |
Het |
| Trh |
T |
C |
6: 92,219,551 (GRCm39) |
E255G |
possibly damaging |
Het |
| Ube4a |
G |
T |
9: 44,871,371 (GRCm39) |
N9K |
probably damaging |
Het |
| Uck1 |
A |
T |
2: 32,148,089 (GRCm39) |
|
probably benign |
Het |
| Vmn2r91 |
T |
G |
17: 18,355,973 (GRCm39) |
|
probably null |
Het |
| Wbp2 |
C |
T |
11: 115,970,534 (GRCm39) |
|
probably null |
Het |
| Zdbf2 |
A |
G |
1: 63,346,636 (GRCm39) |
I1672V |
probably benign |
Het |
|
| Other mutations in Vmn1r222 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01539:Vmn1r222
|
APN |
13 |
23,417,059 (GRCm39) |
missense |
probably benign |
0.45 |
|
IGL01960:Vmn1r222
|
APN |
13 |
23,416,315 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02082:Vmn1r222
|
APN |
13 |
23,416,499 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02616:Vmn1r222
|
APN |
13 |
23,416,311 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL03155:Vmn1r222
|
APN |
13 |
23,416,863 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03333:Vmn1r222
|
APN |
13 |
23,417,177 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL03391:Vmn1r222
|
APN |
13 |
23,416,632 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0137:Vmn1r222
|
UTSW |
13 |
23,416,974 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1584:Vmn1r222
|
UTSW |
13 |
23,416,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2352:Vmn1r222
|
UTSW |
13 |
23,416,683 (GRCm39) |
missense |
probably benign |
0.35 |
|
R3080:Vmn1r222
|
UTSW |
13 |
23,416,631 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R3963:Vmn1r222
|
UTSW |
13 |
23,417,102 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4448:Vmn1r222
|
UTSW |
13 |
23,416,830 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4448:Vmn1r222
|
UTSW |
13 |
23,416,463 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4979:Vmn1r222
|
UTSW |
13 |
23,416,602 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R5054:Vmn1r222
|
UTSW |
13 |
23,416,901 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5182:Vmn1r222
|
UTSW |
13 |
23,416,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5230:Vmn1r222
|
UTSW |
13 |
23,417,172 (GRCm39) |
missense |
probably benign |
|
|
R5462:Vmn1r222
|
UTSW |
13 |
23,417,045 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5611:Vmn1r222
|
UTSW |
13 |
23,416,743 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5677:Vmn1r222
|
UTSW |
13 |
23,416,950 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6298:Vmn1r222
|
UTSW |
13 |
23,416,965 (GRCm39) |
missense |
probably benign |
0.15 |
|
R6655:Vmn1r222
|
UTSW |
13 |
23,416,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6748:Vmn1r222
|
UTSW |
13 |
23,417,117 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6912:Vmn1r222
|
UTSW |
13 |
23,416,374 (GRCm39) |
missense |
probably benign |
0.44 |
|
R7663:Vmn1r222
|
UTSW |
13 |
23,416,601 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7764:Vmn1r222
|
UTSW |
13 |
23,416,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8675:Vmn1r222
|
UTSW |
13 |
23,416,607 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8774:Vmn1r222
|
UTSW |
13 |
23,416,418 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8774-TAIL:Vmn1r222
|
UTSW |
13 |
23,416,418 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9320:Vmn1r222
|
UTSW |
13 |
23,416,418 (GRCm39) |
missense |
probably benign |
0.02 |
|
Z1177:Vmn1r222
|
UTSW |
13 |
23,416,630 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
| Predicted Primers |
PCR Primer
(F):5'- AACCAAGGGTCAGAAACTCATG -3'
(R):5'- GGCCAAAGTATGCATGGCAC -3'
Sequencing Primer
(F):5'- GGGTCAGAAACTCATGAATATTTACC -3'
(R):5'- CTTGTCATTCTTTTGGGTACTCAATG -3'
|
| Posted On |
2015-02-05 |
Incidental Mutation