Incidental Mutation 'R3079:Prl6a1'
ID 265351
Institutional Source Beutler Lab
Gene Symbol Prl6a1
Ensembl Gene ENSMUSG00000069259
Gene Name prolactin family 6, subfamily a, member 1
Synonyms PLP-B, Prlpb
MMRRC Submission 040569-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R3079 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 27496610-27503235 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 27502983 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 193 (D193G)
Ref Sequence ENSEMBL: ENSMUSP00000089269 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091679] [ENSMUST00000091680]
AlphaFold O35257
Predicted Effect possibly damaging
Transcript: ENSMUST00000091679
AA Change: D198G

PolyPhen 2 Score 0.707 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000089268
Gene: ENSMUSG00000069259
AA Change: D198G

DomainStartEndE-ValueType
low complexity region 4 15 N/A INTRINSIC
Pfam:Hormone_1 21 235 8e-65 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000091680
AA Change: D193G

PolyPhen 2 Score 0.707 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000089269
Gene: ENSMUSG00000069259
AA Change: D193G

DomainStartEndE-ValueType
Pfam:Hormone_1 16 230 1.1e-61 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000119758
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aaas A T 15: 102,248,879 (GRCm39) L168H probably damaging Het
Abca15 T C 7: 119,984,392 (GRCm39) W1158R probably damaging Het
Anks4b A T 7: 119,781,146 (GRCm39) D59V probably damaging Het
Aqp11 A T 7: 97,386,795 (GRCm39) C134S probably benign Het
Arhgap35 A G 7: 16,296,501 (GRCm39) Y855H probably damaging Het
Ces1c A C 8: 93,846,975 (GRCm39) L93R probably damaging Het
Cit A G 5: 116,063,545 (GRCm39) D462G probably damaging Het
Col6a6 T C 9: 105,631,422 (GRCm39) R1494G probably benign Het
Edc4 T C 8: 106,611,750 (GRCm39) S109P possibly damaging Het
Elp4 T C 2: 105,639,790 (GRCm39) K130E possibly damaging Het
Gemin5 A T 11: 58,036,345 (GRCm39) V666E probably damaging Het
Hba-x A G 11: 32,227,616 (GRCm39) D62G probably damaging Het
Hnrnpul1 A T 7: 25,432,540 (GRCm39) Y474* probably null Het
Ighv5-6 T A 12: 113,589,237 (GRCm39) D81V probably damaging Het
Krt1 C T 15: 101,754,622 (GRCm39) G543S unknown Het
Mbtps1 A G 8: 120,257,944 (GRCm39) V431A probably benign Het
Mbtps1 T C 8: 120,265,602 (GRCm39) D315G probably damaging Het
Mrc2 T C 11: 105,227,539 (GRCm39) S591P probably damaging Het
Msh5 T C 17: 35,265,208 (GRCm39) E48G probably benign Het
Mybpc2 T C 7: 44,155,505 (GRCm39) D916G probably damaging Het
Nebl A G 2: 17,381,462 (GRCm39) V738A possibly damaging Het
Nlrp1b T C 11: 71,108,794 (GRCm39) R236G probably benign Het
Obsl1 G T 1: 75,467,467 (GRCm39) R1436S probably damaging Het
Or14j4 T C 17: 37,921,169 (GRCm39) T158A probably benign Het
Or51a7 C T 7: 102,622,254 (GRCm39) probably null Het
Padi2 T C 4: 140,677,189 (GRCm39) V659A probably damaging Het
Pnpla6 T G 8: 3,591,512 (GRCm39) S1169A probably benign Het
Pramel30 T G 4: 144,058,098 (GRCm39) L235R probably damaging Het
Rce1 G T 19: 4,674,750 (GRCm39) C138* probably null Het
Shoc1 G T 4: 59,047,848 (GRCm39) T1257N possibly damaging Het
Shroom3 G T 5: 93,090,945 (GRCm39) V1151F probably damaging Het
Skint2 A G 4: 112,496,870 (GRCm39) T259A probably benign Het
Slc66a1 G T 4: 139,033,829 (GRCm39) A30D probably damaging Het
Slco5a1 C T 1: 12,949,486 (GRCm39) G635S probably damaging Het
Slfn1 T C 11: 83,011,986 (GRCm39) V34A probably benign Het
Syt4 A G 18: 31,574,738 (GRCm39) V293A probably benign Het
Trh T C 6: 92,219,551 (GRCm39) E255G possibly damaging Het
Ube4a G T 9: 44,871,371 (GRCm39) N9K probably damaging Het
Uck1 A T 2: 32,148,089 (GRCm39) probably benign Het
Vmn1r222 A G 13: 23,416,631 (GRCm39) M194T possibly damaging Het
Vmn2r91 T G 17: 18,355,973 (GRCm39) probably null Het
Wbp2 C T 11: 115,970,534 (GRCm39) probably null Het
Zdbf2 A G 1: 63,346,636 (GRCm39) I1672V probably benign Het
Other mutations in Prl6a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01124:Prl6a1 APN 13 27,500,347 (GRCm39) missense possibly damaging 0.72
IGL01688:Prl6a1 APN 13 27,501,969 (GRCm39) missense probably damaging 1.00
IGL01922:Prl6a1 APN 13 27,499,343 (GRCm39) missense possibly damaging 0.57
IGL02059:Prl6a1 APN 13 27,499,348 (GRCm39) missense probably benign 0.02
IGL03170:Prl6a1 APN 13 27,499,406 (GRCm39) missense possibly damaging 0.95
R0027:Prl6a1 UTSW 13 27,502,011 (GRCm39) missense probably damaging 1.00
R0027:Prl6a1 UTSW 13 27,502,011 (GRCm39) missense probably damaging 1.00
R0049:Prl6a1 UTSW 13 27,501,980 (GRCm39) missense probably damaging 0.99
R0606:Prl6a1 UTSW 13 27,498,177 (GRCm39) intron probably benign
R0944:Prl6a1 UTSW 13 27,502,149 (GRCm39) splice site probably benign
R1518:Prl6a1 UTSW 13 27,502,911 (GRCm39) missense probably null 0.19
R1518:Prl6a1 UTSW 13 27,502,910 (GRCm39) missense possibly damaging 0.72
R1566:Prl6a1 UTSW 13 27,499,410 (GRCm39) missense possibly damaging 0.84
R1621:Prl6a1 UTSW 13 27,501,993 (GRCm39) missense probably benign 0.01
R2011:Prl6a1 UTSW 13 27,499,352 (GRCm39) missense probably benign 0.00
R2058:Prl6a1 UTSW 13 27,503,081 (GRCm39) missense probably benign 0.05
R2937:Prl6a1 UTSW 13 27,499,303 (GRCm39) missense probably damaging 0.98
R4685:Prl6a1 UTSW 13 27,500,307 (GRCm39) missense probably benign 0.00
R4856:Prl6a1 UTSW 13 27,502,983 (GRCm39) missense probably damaging 0.98
R4886:Prl6a1 UTSW 13 27,502,983 (GRCm39) missense probably damaging 0.98
R5495:Prl6a1 UTSW 13 27,496,654 (GRCm39) missense possibly damaging 0.95
R5923:Prl6a1 UTSW 13 27,500,346 (GRCm39) missense probably benign 0.08
R6772:Prl6a1 UTSW 13 27,503,031 (GRCm39) missense probably damaging 1.00
R7411:Prl6a1 UTSW 13 27,502,125 (GRCm39) missense probably damaging 1.00
R7501:Prl6a1 UTSW 13 27,500,282 (GRCm39) missense possibly damaging 0.69
R7549:Prl6a1 UTSW 13 27,502,954 (GRCm39) missense probably damaging 0.96
R7563:Prl6a1 UTSW 13 27,498,221 (GRCm39) critical splice donor site probably null
R7773:Prl6a1 UTSW 13 27,502,125 (GRCm39) missense probably damaging 1.00
R8024:Prl6a1 UTSW 13 27,502,678 (GRCm39) intron probably benign
R8994:Prl6a1 UTSW 13 27,499,417 (GRCm39) missense probably benign 0.01
R9129:Prl6a1 UTSW 13 27,502,064 (GRCm39) missense
R9395:Prl6a1 UTSW 13 27,499,400 (GRCm39) missense possibly damaging 0.71
Z1177:Prl6a1 UTSW 13 27,499,304 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATTCACACTACTTTGGCATAGAGAC -3'
(R):5'- GTATTACAGGGTGAAATGAGATGTC -3'

Sequencing Primer
(F):5'- CATCCCAAGAGTTCTTTCAA -3'
(R):5'- AGACATCAACATGTTTAAAGAGTCTG -3'
Posted On 2015-02-05