Incidental Mutation 'R3082:Or4l15'
ID 265502
Institutional Source Beutler Lab
Gene Symbol Or4l15
Ensembl Gene ENSMUSG00000096254
Gene Name olfactory receptor family 4 subfamily L member 15
Synonyms MOR247-2, Olfr724, GA_x6K02T2PMLR-5645801-5644872
MMRRC Submission 040572-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.220) question?
Stock # R3082 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 50197548-50198553 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 50198161 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 123 (Y123H)
Ref Sequence ENSEMBL: ENSMUSP00000149110 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075030] [ENSMUST00000213390]
AlphaFold K7N5X7
Predicted Effect probably damaging
Transcript: ENSMUST00000075030
AA Change: Y123H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000074546
Gene: ENSMUSG00000096254
AA Change: Y123H

DomainStartEndE-ValueType
Pfam:7tm_4 31 305 1.3e-42 PFAM
Pfam:7TM_GPCR_Srsx 34 302 3e-11 PFAM
Pfam:7tm_1 41 287 5.3e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213390
AA Change: Y123H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.1884 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency 100% (44/44)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acss3 A G 10: 106,859,576 (GRCm39) V341A possibly damaging Het
Adam11 T C 11: 102,660,943 (GRCm39) probably benign Het
Aox1 G T 1: 58,322,759 (GRCm39) probably benign Het
Cdh6 T C 15: 13,044,838 (GRCm39) D428G probably damaging Het
Cep63 T C 9: 102,479,696 (GRCm39) T339A probably benign Het
Clcn1 T C 6: 42,267,112 (GRCm39) Y66H probably damaging Het
Cpsf2 C G 12: 101,955,069 (GRCm39) S280C probably damaging Het
Dcaf6 G T 1: 165,250,421 (GRCm39) probably benign Het
Ddx39a T A 8: 84,449,335 (GRCm39) N344K possibly damaging Het
Dvl1 T C 4: 155,932,316 (GRCm39) V42A possibly damaging Het
Ep400 A G 5: 110,841,096 (GRCm39) probably benign Het
Epb41l5 C T 1: 119,536,992 (GRCm39) V300I probably damaging Het
Fbln1 T G 15: 85,149,454 (GRCm39) I617S probably benign Het
Gas2l3 CACTCGTCATACT CACT 10: 89,266,820 (GRCm39) probably benign Het
Grin3a G A 4: 49,665,243 (GRCm39) R1131W probably benign Het
Incenp T A 19: 9,861,143 (GRCm39) M480L unknown Het
Ints13 G T 6: 146,476,205 (GRCm39) Q99K possibly damaging Het
L2hgdh C T 12: 69,768,858 (GRCm39) D85N probably benign Het
Lct A G 1: 128,215,345 (GRCm39) Y1744H probably damaging Het
Macf1 T C 4: 123,255,236 (GRCm39) probably null Het
Mpdz A T 4: 81,203,695 (GRCm39) probably benign Het
Naa15 T C 3: 51,367,471 (GRCm39) L498P probably damaging Het
Naip6 T A 13: 100,452,925 (GRCm39) E45D probably benign Het
Nedd4l T A 18: 65,312,049 (GRCm39) N405K probably benign Het
Or8u10 C T 2: 85,916,053 (GRCm39) V23I probably benign Het
Pitpnc1 A G 11: 107,103,350 (GRCm39) S250P possibly damaging Het
Ppp1r18 A G 17: 36,184,742 (GRCm39) D131G probably damaging Het
Prdm5 A G 6: 65,913,069 (GRCm39) D206G probably damaging Het
Pygl A G 12: 70,244,303 (GRCm39) F455S probably damaging Het
Rictor A T 15: 6,804,338 (GRCm39) Y565F probably benign Het
Ryr1 T C 7: 28,745,071 (GRCm39) N3852D probably damaging Het
S1pr5 A T 9: 21,156,286 (GRCm39) C47S probably damaging Het
Serpinf2 T C 11: 75,328,354 (GRCm39) R65G probably benign Het
Slfn14 C T 11: 83,167,519 (GRCm39) W665* probably null Het
Smu1 T C 4: 40,745,567 (GRCm39) D251G probably damaging Het
Spata18 A G 5: 73,836,423 (GRCm39) probably benign Het
Tex19.2 A G 11: 121,007,557 (GRCm39) V297A probably benign Het
Tmem131l A G 3: 83,816,457 (GRCm39) probably null Het
Trim9 T C 12: 70,301,887 (GRCm39) R584G possibly damaging Het
Trpm7 A T 2: 126,686,342 (GRCm39) N295K possibly damaging Het
Ugt2a3 A G 5: 87,473,534 (GRCm39) V461A probably benign Het
Vmn1r45 A T 6: 89,910,724 (GRCm39) M82K probably benign Het
Other mutations in Or4l15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02811:Or4l15 APN 14 50,197,590 (GRCm39) utr 3 prime probably benign
R0829:Or4l15 UTSW 14 50,198,503 (GRCm39) missense probably benign 0.03
R1513:Or4l15 UTSW 14 50,198,558 (GRCm39) critical splice acceptor site probably null
R2016:Or4l15 UTSW 14 50,197,959 (GRCm39) missense probably benign 0.00
R2936:Or4l15 UTSW 14 50,197,611 (GRCm39) missense probably benign 0.03
R3738:Or4l15 UTSW 14 50,198,013 (GRCm39) missense possibly damaging 0.60
R4772:Or4l15 UTSW 14 50,198,452 (GRCm39) small deletion probably benign
R4830:Or4l15 UTSW 14 50,197,681 (GRCm39) missense probably damaging 1.00
R4839:Or4l15 UTSW 14 50,197,646 (GRCm39) missense probably benign 0.41
R5362:Or4l15 UTSW 14 50,197,986 (GRCm39) missense possibly damaging 0.95
R5695:Or4l15 UTSW 14 50,198,080 (GRCm39) missense probably benign 0.00
R6187:Or4l15 UTSW 14 50,198,526 (GRCm39) start codon destroyed probably null 0.99
R7371:Or4l15 UTSW 14 50,198,563 (GRCm39) splice site probably null
R7611:Or4l15 UTSW 14 50,198,368 (GRCm39) missense probably benign 0.03
R9243:Or4l15 UTSW 14 50,197,881 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- TGATTACCAGGGGAAGGTCG -3'
(R):5'- AGTCACAGTGGCAGCTAATTC -3'

Sequencing Primer
(F):5'- CCAATTGTCCAGGAAAGG -3'
(R):5'- TCTTGGAAACCTCTCCTTCCTAGAC -3'
Posted On 2015-02-05