Incidental Mutation 'R3086:Or6c88'
ID 265641
Institutional Source Beutler Lab
Gene Symbol Or6c88
Ensembl Gene ENSMUSG00000044293
Gene Name olfactory receptor family 6 subfamily C member 88
Synonyms MOR114-11, Olfr794, GA_x6K02T2PULF-11248702-11249664
MMRRC Submission 040575-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R3086 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 129406526-129407488 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 129407276 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Serine at position 251 (G251S)
Ref Sequence ENSEMBL: ENSMUSP00000145301 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059957] [ENSMUST00000204820]
AlphaFold Q8VF26
Predicted Effect probably damaging
Transcript: ENSMUST00000059957
AA Change: G251S

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000049790
Gene: ENSMUSG00000044293
AA Change: G251S

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 2.8e-49 PFAM
Pfam:7tm_1 39 288 2e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000204820
AA Change: G251S

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000145301
Gene: ENSMUSG00000044293
AA Change: G251S

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 2.8e-49 PFAM
Pfam:7tm_1 39 288 2e-22 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.8%
Validation Efficiency 100% (42/42)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310039H08Rik T C 17: 47,083,881 (GRCm39) L48P probably damaging Het
Adgra3 A T 5: 50,170,733 (GRCm39) probably null Het
Alms1 A G 6: 85,655,122 (GRCm39) R3223G probably benign Het
Bltp1 A G 3: 37,065,852 (GRCm39) D3483G possibly damaging Het
Cabyr T C 18: 12,884,023 (GRCm39) V170A probably damaging Het
Ces2b A T 8: 105,559,401 (GRCm39) D89V possibly damaging Het
Dhrs2 G T 14: 55,477,301 (GRCm39) V179L probably benign Het
Dlg5 T C 14: 24,216,258 (GRCm39) T595A probably damaging Het
Dock10 T C 1: 80,510,074 (GRCm39) N1585D possibly damaging Het
Dock4 T C 12: 40,781,862 (GRCm39) I689T probably benign Het
Fgfr4 G T 13: 55,315,205 (GRCm39) probably benign Het
Frk G A 10: 34,483,950 (GRCm39) G437D probably damaging Het
Frzb T G 2: 80,248,858 (GRCm39) I199L possibly damaging Het
Gsg1l C T 7: 125,490,852 (GRCm39) R284H probably benign Het
Helq A G 5: 100,921,858 (GRCm39) L782S probably benign Het
Kif20b T C 19: 34,907,115 (GRCm39) F128S probably damaging Het
Kifc2 T C 15: 76,551,452 (GRCm39) F725L probably benign Het
Lekr1 A G 3: 65,634,581 (GRCm39) noncoding transcript Het
Macf1 T A 4: 123,328,901 (GRCm39) M2490L probably benign Het
Megf8 T A 7: 25,048,444 (GRCm39) Y1706N probably damaging Het
N4bp2 A G 5: 65,948,396 (GRCm39) Y342C probably damaging Het
Nf1 T C 11: 79,437,812 (GRCm39) C2057R probably damaging Het
Or4f60 C A 2: 111,902,320 (GRCm39) G203* probably null Het
Or4k36 A G 2: 111,146,461 (GRCm39) I212M probably benign Het
Orc4 G A 2: 48,827,501 (GRCm39) P31S probably benign Het
Pcdha1 G C 18: 37,064,001 (GRCm39) E222Q possibly damaging Het
Prune2 A T 19: 17,098,777 (GRCm39) D1427V possibly damaging Het
Rnps1 C T 17: 24,631,393 (GRCm39) probably benign Het
Rsph4a G C 10: 33,785,198 (GRCm39) V370L probably damaging Het
Sema5b T A 16: 35,443,093 (GRCm39) S33T probably benign Het
Stk-ps2 A C 1: 46,068,236 (GRCm39) noncoding transcript Het
Tep1 A T 14: 51,064,511 (GRCm39) probably null Het
Tet1 T C 10: 62,715,400 (GRCm39) K132E probably benign Het
Tiam2 A G 17: 3,471,857 (GRCm39) K500E probably damaging Het
Tmem131l G T 3: 83,839,046 (GRCm39) R635S probably benign Het
Tmem68 T C 4: 3,569,594 (GRCm39) E32G possibly damaging Het
Vmn2r101 T A 17: 19,809,077 (GRCm39) probably null Het
Zfp780b A G 7: 27,663,055 (GRCm39) I500T probably damaging Het
Zfyve26 G T 12: 79,312,457 (GRCm39) probably benign Het
Other mutations in Or6c88
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01867:Or6c88 APN 10 129,406,696 (GRCm39) missense possibly damaging 0.95
IGL02157:Or6c88 APN 10 129,407,019 (GRCm39) missense probably damaging 1.00
IGL02804:Or6c88 APN 10 129,407,306 (GRCm39) missense possibly damaging 0.60
IGL02833:Or6c88 APN 10 129,406,619 (GRCm39) missense probably benign 0.26
IGL02930:Or6c88 APN 10 129,407,184 (GRCm39) missense probably damaging 1.00
IGL03038:Or6c88 APN 10 129,406,790 (GRCm39) missense probably benign 0.07
G4846:Or6c88 UTSW 10 129,407,039 (GRCm39) missense probably damaging 1.00
R1539:Or6c88 UTSW 10 129,406,640 (GRCm39) missense probably damaging 0.99
R1737:Or6c88 UTSW 10 129,406,697 (GRCm39) missense probably damaging 1.00
R1845:Or6c88 UTSW 10 129,407,217 (GRCm39) missense probably damaging 1.00
R2198:Or6c88 UTSW 10 129,406,915 (GRCm39) nonsense probably null
R4960:Or6c88 UTSW 10 129,406,895 (GRCm39) missense probably damaging 1.00
R5938:Or6c88 UTSW 10 129,407,396 (GRCm39) missense probably damaging 1.00
R6326:Or6c88 UTSW 10 129,406,571 (GRCm39) missense possibly damaging 0.74
R6598:Or6c88 UTSW 10 129,407,238 (GRCm39) missense probably damaging 1.00
R7034:Or6c88 UTSW 10 129,406,941 (GRCm39) missense possibly damaging 0.91
R7066:Or6c88 UTSW 10 129,407,373 (GRCm39) missense probably damaging 1.00
R7226:Or6c88 UTSW 10 129,406,584 (GRCm39) missense probably benign 0.01
R7324:Or6c88 UTSW 10 129,406,718 (GRCm39) missense probably damaging 1.00
R7408:Or6c88 UTSW 10 129,406,493 (GRCm39) start gained probably benign
R7779:Or6c88 UTSW 10 129,407,180 (GRCm39) missense probably damaging 1.00
R8733:Or6c88 UTSW 10 129,406,579 (GRCm39) missense possibly damaging 0.90
R8891:Or6c88 UTSW 10 129,407,046 (GRCm39) missense probably damaging 0.99
R8931:Or6c88 UTSW 10 129,406,550 (GRCm39) missense probably benign 0.09
R9310:Or6c88 UTSW 10 129,406,687 (GRCm39) missense probably benign 0.00
R9681:Or6c88 UTSW 10 129,406,664 (GRCm39) missense probably damaging 1.00
Z1176:Or6c88 UTSW 10 129,407,105 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AGCAGACTGTCATTGTTTGTGC -3'
(R):5'- GGCTGAAATAGTTAAAACCTCCAG -3'

Sequencing Primer
(F):5'- GTGCAGTGCTGACTTTCATC -3'
(R):5'- CCAACATGTTCTTATTGGTGTAAGAG -3'
Posted On 2015-02-05