Mutagenetix > Incidental Mutation

Incidental Mutation 'R3086:Vmn2r101'

265653

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r101

Ensembl Gene

ENSMUSG00000094892

Gene Name

vomeronasal 2, receptor 101

Synonyms

EG627576

MMRRC Submission

040575-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.124) question?

Stock #

R3086 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

19797493-19832579 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 19809077 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000131583 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171914] [ENSMUST00000171914]

AlphaFold

E9PZS9

Predicted Effect

probably null
Transcript: ENSMUST00000171914

SMART Domains

Protein: ENSMUSP00000131583
Gene: ENSMUSG00000094892

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	466	1.6e-36	PFAM
Pfam:NCD3G	509	562	6.4e-22	PFAM
Pfam:7tm_3	595	830	1.4e-51	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000171914

SMART Domains

Protein: ENSMUSP00000131583
Gene: ENSMUSG00000094892

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	466	1.6e-36	PFAM
Pfam:NCD3G	509	562	6.4e-22	PFAM
Pfam:7tm_3	595	830	1.4e-51	PFAM

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.2%
20x: 94.8%

Validation Efficiency

100% (42/42)

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310039H08Rik	T	C	17: 47,083,881 (GRCm39)	L48P	probably damaging	Het
Adgra3	A	T	5: 50,170,733 (GRCm39)		probably null	Het
Alms1	A	G	6: 85,655,122 (GRCm39)	R3223G	probably benign	Het
Bltp1	A	G	3: 37,065,852 (GRCm39)	D3483G	possibly damaging	Het
Cabyr	T	C	18: 12,884,023 (GRCm39)	V170A	probably damaging	Het
Ces2b	A	T	8: 105,559,401 (GRCm39)	D89V	possibly damaging	Het
Dhrs2	G	T	14: 55,477,301 (GRCm39)	V179L	probably benign	Het
Dlg5	T	C	14: 24,216,258 (GRCm39)	T595A	probably damaging	Het
Dock10	T	C	1: 80,510,074 (GRCm39)	N1585D	possibly damaging	Het
Dock4	T	C	12: 40,781,862 (GRCm39)	I689T	probably benign	Het
Fgfr4	G	T	13: 55,315,205 (GRCm39)		probably benign	Het
Frk	G	A	10: 34,483,950 (GRCm39)	G437D	probably damaging	Het
Frzb	T	G	2: 80,248,858 (GRCm39)	I199L	possibly damaging	Het
Gsg1l	C	T	7: 125,490,852 (GRCm39)	R284H	probably benign	Het
Helq	A	G	5: 100,921,858 (GRCm39)	L782S	probably benign	Het
Kif20b	T	C	19: 34,907,115 (GRCm39)	F128S	probably damaging	Het
Kifc2	T	C	15: 76,551,452 (GRCm39)	F725L	probably benign	Het
Lekr1	A	G	3: 65,634,581 (GRCm39)		noncoding transcript	Het
Macf1	T	A	4: 123,328,901 (GRCm39)	M2490L	probably benign	Het
Megf8	T	A	7: 25,048,444 (GRCm39)	Y1706N	probably damaging	Het
N4bp2	A	G	5: 65,948,396 (GRCm39)	Y342C	probably damaging	Het
Nf1	T	C	11: 79,437,812 (GRCm39)	C2057R	probably damaging	Het
Or4f60	C	A	2: 111,902,320 (GRCm39)	G203*	probably null	Het
Or4k36	A	G	2: 111,146,461 (GRCm39)	I212M	probably benign	Het
Or6c88	G	A	10: 129,407,276 (GRCm39)	G251S	probably damaging	Het
Orc4	G	A	2: 48,827,501 (GRCm39)	P31S	probably benign	Het
Pcdha1	G	C	18: 37,064,001 (GRCm39)	E222Q	possibly damaging	Het
Prune2	A	T	19: 17,098,777 (GRCm39)	D1427V	possibly damaging	Het
Rnps1	C	T	17: 24,631,393 (GRCm39)		probably benign	Het
Rsph4a	G	C	10: 33,785,198 (GRCm39)	V370L	probably damaging	Het
Sema5b	T	A	16: 35,443,093 (GRCm39)	S33T	probably benign	Het
Stk-ps2	A	C	1: 46,068,236 (GRCm39)		noncoding transcript	Het
Tep1	A	T	14: 51,064,511 (GRCm39)		probably null	Het
Tet1	T	C	10: 62,715,400 (GRCm39)	K132E	probably benign	Het
Tiam2	A	G	17: 3,471,857 (GRCm39)	K500E	probably damaging	Het
Tmem131l	G	T	3: 83,839,046 (GRCm39)	R635S	probably benign	Het
Tmem68	T	C	4: 3,569,594 (GRCm39)	E32G	possibly damaging	Het
Zfp780b	A	G	7: 27,663,055 (GRCm39)	I500T	probably damaging	Het
Zfyve26	G	T	12: 79,312,457 (GRCm39)		probably benign	Het

Other mutations in Vmn2r101

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01121:Vmn2r101	APN	17	19,809,936 (GRCm39)	missense	probably damaging	0.99
IGL02125:Vmn2r101	APN	17	19,809,963 (GRCm39)	missense	possibly damaging	0.95
IGL02300:Vmn2r101	APN	17	19,832,199 (GRCm39)	missense	probably damaging	1.00
IGL02682:Vmn2r101	APN	17	19,832,507 (GRCm39)	missense	possibly damaging	0.82
IGL02825:Vmn2r101	APN	17	19,810,132 (GRCm39)	missense	probably benign	0.00
IGL02862:Vmn2r101	APN	17	19,831,867 (GRCm39)	missense	probably damaging	1.00
IGL02943:Vmn2r101	APN	17	19,831,666 (GRCm39)	missense	probably damaging	0.99
R0371:Vmn2r101	UTSW	17	19,810,394 (GRCm39)	missense	probably benign	0.07
R0462:Vmn2r101	UTSW	17	19,810,431 (GRCm39)	missense	probably benign	0.04
R0492:Vmn2r101	UTSW	17	19,809,245 (GRCm39)	missense	probably damaging	1.00
R0654:Vmn2r101	UTSW	17	19,810,373 (GRCm39)	missense	probably benign	0.01
R1120:Vmn2r101	UTSW	17	19,797,723 (GRCm39)	splice site	probably benign
R1323:Vmn2r101	UTSW	17	19,832,313 (GRCm39)	missense	probably damaging	1.00
R1323:Vmn2r101	UTSW	17	19,832,313 (GRCm39)	missense	probably damaging	1.00
R1676:Vmn2r101	UTSW	17	19,832,184 (GRCm39)	missense	probably benign	0.00
R2023:Vmn2r101	UTSW	17	19,810,368 (GRCm39)	nonsense	probably null
R2149:Vmn2r101	UTSW	17	19,809,225 (GRCm39)	missense	probably benign	0.00
R2350:Vmn2r101	UTSW	17	19,810,045 (GRCm39)	missense	probably benign	0.01
R2760:Vmn2r101	UTSW	17	19,809,901 (GRCm39)	missense	probably benign	0.14
R3085:Vmn2r101	UTSW	17	19,809,077 (GRCm39)	splice site	probably null
R3719:Vmn2r101	UTSW	17	19,809,811 (GRCm39)	missense	possibly damaging	0.50
R3771:Vmn2r101	UTSW	17	19,809,919 (GRCm39)	missense	probably benign
R3773:Vmn2r101	UTSW	17	19,809,919 (GRCm39)	missense	probably benign
R4225:Vmn2r101	UTSW	17	19,831,951 (GRCm39)	missense	probably damaging	1.00
R4248:Vmn2r101	UTSW	17	19,809,376 (GRCm39)	missense	probably damaging	1.00
R4290:Vmn2r101	UTSW	17	19,832,303 (GRCm39)	missense	probably damaging	1.00
R4291:Vmn2r101	UTSW	17	19,832,303 (GRCm39)	missense	probably damaging	1.00
R4293:Vmn2r101	UTSW	17	19,832,303 (GRCm39)	missense	probably damaging	1.00
R4307:Vmn2r101	UTSW	17	19,810,423 (GRCm39)	missense	probably damaging	1.00
R4721:Vmn2r101	UTSW	17	19,832,287 (GRCm39)	missense	probably damaging	0.99
R4829:Vmn2r101	UTSW	17	19,832,229 (GRCm39)	missense	probably benign	0.03
R5022:Vmn2r101	UTSW	17	19,831,649 (GRCm39)	critical splice acceptor site	probably null
R5110:Vmn2r101	UTSW	17	19,831,897 (GRCm39)	missense	possibly damaging	0.92
R5244:Vmn2r101	UTSW	17	19,831,788 (GRCm39)	missense	probably damaging	1.00
R5397:Vmn2r101	UTSW	17	19,809,104 (GRCm39)	missense	probably damaging	1.00
R5875:Vmn2r101	UTSW	17	19,809,092 (GRCm39)	missense	probably damaging	0.99
R5944:Vmn2r101	UTSW	17	19,809,769 (GRCm39)	missense	probably benign	0.00
R6216:Vmn2r101	UTSW	17	19,811,267 (GRCm39)	missense	probably benign	0.00
R6334:Vmn2r101	UTSW	17	19,810,112 (GRCm39)	missense	possibly damaging	0.83
R6512:Vmn2r101	UTSW	17	19,809,146 (GRCm39)	missense	probably damaging	1.00
R6607:Vmn2r101	UTSW	17	19,832,296 (GRCm39)	missense	probably damaging	1.00
R6965:Vmn2r101	UTSW	17	19,811,284 (GRCm39)	missense	probably benign	0.00
R7101:Vmn2r101	UTSW	17	19,809,350 (GRCm39)	missense	probably null	0.14
R7183:Vmn2r101	UTSW	17	19,832,440 (GRCm39)	missense	probably damaging	1.00
R7344:Vmn2r101	UTSW	17	19,832,059 (GRCm39)	missense	probably benign	0.38
R7375:Vmn2r101	UTSW	17	19,831,652 (GRCm39)	missense	probably damaging	1.00
R7574:Vmn2r101	UTSW	17	19,831,899 (GRCm39)	missense	possibly damaging	0.91
R7575:Vmn2r101	UTSW	17	19,831,654 (GRCm39)	missense	probably benign	0.01
R7592:Vmn2r101	UTSW	17	19,811,443 (GRCm39)	splice site	probably null
R7626:Vmn2r101	UTSW	17	19,832,192 (GRCm39)	nonsense	probably null
R7715:Vmn2r101	UTSW	17	19,832,177 (GRCm39)	missense	probably damaging	1.00
R7730:Vmn2r101	UTSW	17	19,831,950 (GRCm39)	missense	possibly damaging	0.81
R8078:Vmn2r101	UTSW	17	19,810,507 (GRCm39)	missense	probably benign	0.07
R8228:Vmn2r101	UTSW	17	19,811,284 (GRCm39)	missense	probably benign	0.00
R8283:Vmn2r101	UTSW	17	19,832,253 (GRCm39)	missense	probably damaging	1.00
R8712:Vmn2r101	UTSW	17	19,811,397 (GRCm39)	missense	probably benign	0.24
R8765:Vmn2r101	UTSW	17	19,809,245 (GRCm39)	missense	probably damaging	1.00
R9091:Vmn2r101	UTSW	17	19,810,244 (GRCm39)	missense	probably benign
R9092:Vmn2r101	UTSW	17	19,809,807 (GRCm39)	missense	probably benign	0.07
R9113:Vmn2r101	UTSW	17	19,811,288 (GRCm39)	missense	possibly damaging	0.56
R9158:Vmn2r101	UTSW	17	19,809,161 (GRCm39)	missense	probably benign	0.00
R9168:Vmn2r101	UTSW	17	19,809,138 (GRCm39)	missense	probably damaging	1.00
R9235:Vmn2r101	UTSW	17	19,810,238 (GRCm39)	missense	probably damaging	0.99
R9270:Vmn2r101	UTSW	17	19,810,244 (GRCm39)	missense	probably benign
R9290:Vmn2r101	UTSW	17	19,811,395 (GRCm39)	missense	probably benign	0.05
R9296:Vmn2r101	UTSW	17	19,810,047 (GRCm39)	missense	probably damaging	0.98
R9602:Vmn2r101	UTSW	17	19,831,780 (GRCm39)	nonsense	probably null
R9706:Vmn2r101	UTSW	17	19,809,925 (GRCm39)	missense	probably damaging	1.00
Z1088:Vmn2r101	UTSW	17	19,809,237 (GRCm39)	missense	possibly damaging	0.78

Predicted Primers

PCR Primer
(F):5'- CAAAAGATCTACATTCCAACAGGTG -3'
(R):5'- AGTGCTGCAGTGAAATTTCTC -3'

Sequencing Primer
(F):5'- CCAACAGGTGGGCTTTTGG -3'
(R):5'- ACTTTCTTTGCACAAGAGCTG -3'

Posted On

2015-02-05