Mutagenetix > Incidental Mutation

Incidental Mutation 'R3024:Vmn1r238'

265785

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r238

Ensembl Gene

ENSMUSG00000091539

Gene Name

vomeronasal 1 receptor, 238

Synonyms

MMRRC Submission

040540-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.062) question?

Stock #

R3024 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

3122492-3123412 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 3123305 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Methionine at position 36 (I36M)

Ref Sequence

ENSEMBL: ENSMUSP00000129804 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165255]

AlphaFold

E9Q373

Predicted Effect

probably benign
Transcript: ENSMUST00000165255
AA Change: I36M

PolyPhen 2 Score 0.126 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000129804
Gene: ENSMUSG00000091539
AA Change: I36M

Domain	Start	End	E-Value	Type
Pfam:TAS2R	7	302	5.3e-8	PFAM
Pfam:7tm_1	27	292	8.8e-7	PFAM
Pfam:V1R	34	298	1.9e-33	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.1%
20x: 94.5%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 22 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arhgef37	T	C	18: 61,501,888	E461G	probably damaging	Het
Bfsp1	A	T	2: 143,845,959	V182D	probably benign	Het
Birc6	T	C	17: 74,608,219	S1635P	possibly damaging	Het
Chil6	T	C	3: 106,388,770	D383G	probably damaging	Het
Itpr2	G	A	6: 146,180,310	A175V	probably benign	Het
Kcnh7	G	T	2: 62,764,663	R688S	probably damaging	Het
Krt6a	A	T	15: 101,691,289	C463S	probably benign	Het
Ksr2	T	A	5: 117,555,060	I191N	possibly damaging	Het
Lyst	T	C	13: 13,658,687	V1698A	probably benign	Het
Olfr103	A	T	17: 37,337,027	D68E	probably damaging	Het
Olfr1262	A	T	2: 90,003,240	N278I	probably damaging	Het
Pappa2	C	T	1: 158,936,225	R572Q	probably benign	Het
Pes1	CGGAGGAGGAGGAGGAGGAGGAGG	CGGAGGAGGAGGAGGAGGAGG	11: 3,977,719		probably benign	Het
Phf20	A	G	2: 156,287,867	H453R	probably damaging	Het
Prex1	G	T	2: 166,589,036	H615Q	probably benign	Het
Slc25a54	T	A	3: 109,080,666	I41N	probably damaging	Het
Slc35f5	A	G	1: 125,568,598	S157G	probably benign	Het
Sstr3	G	A	15: 78,539,987	R187W	probably damaging	Het
Trim41	T	C	11: 48,808,158	K420E	possibly damaging	Het
Tsnaxip1	A	G	8: 105,841,743	Y353C	probably damaging	Het
Xylt1	T	A	7: 117,548,648	V149D	probably damaging	Het
Zfpm2	G	A	15: 41,102,959	E815K	probably benign	Het

Other mutations in Vmn1r238

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00427:Vmn1r238	APN	18	3123243	missense	probably benign	0.01
IGL01385:Vmn1r238	APN	18	3122770	missense	possibly damaging	0.83
IGL02716:Vmn1r238	APN	18	3123124	missense	probably damaging	1.00
R1219:Vmn1r238	UTSW	18	3123135	missense	possibly damaging	0.81
R1568:Vmn1r238	UTSW	18	3123358	missense	probably benign	0.00
R1864:Vmn1r238	UTSW	18	3123040	nonsense	probably null
R4291:Vmn1r238	UTSW	18	3123214	nonsense	probably null
R4304:Vmn1r238	UTSW	18	3123040	nonsense	probably null
R4586:Vmn1r238	UTSW	18	3123294	missense	probably damaging	1.00
R4664:Vmn1r238	UTSW	18	3123300	missense	probably damaging	0.99
R5123:Vmn1r238	UTSW	18	3123243	missense	probably benign
R5430:Vmn1r238	UTSW	18	3122521	missense	possibly damaging	0.63
R5834:Vmn1r238	UTSW	18	3123168	missense	probably benign
R7186:Vmn1r238	UTSW	18	3122661	missense	probably damaging	0.99
R7206:Vmn1r238	UTSW	18	3122623	missense	possibly damaging	0.94
R7308:Vmn1r238	UTSW	18	3122875	missense	probably benign	0.09
R7346:Vmn1r238	UTSW	18	3123151	missense	probably damaging	1.00
R7467:Vmn1r238	UTSW	18	3123393	missense	probably benign	0.10
R7571:Vmn1r238	UTSW	18	3122721	missense	probably damaging	1.00
R7808:Vmn1r238	UTSW	18	3123033	missense	probably benign	0.03
R8085:Vmn1r238	UTSW	18	3123151	missense	probably damaging	1.00
R8086:Vmn1r238	UTSW	18	3123250	missense	probably damaging	1.00
R8325:Vmn1r238	UTSW	18	3122529	missense	probably benign	0.00
R8423:Vmn1r238	UTSW	18	3123365	nonsense	probably null
R8747:Vmn1r238	UTSW	18	3123232	missense	possibly damaging	0.87
R8930:Vmn1r238	UTSW	18	3123127	missense	probably benign	0.03
R8932:Vmn1r238	UTSW	18	3123127	missense	probably benign	0.03
R9279:Vmn1r238	UTSW	18	3122994	missense	probably damaging	0.99
R9382:Vmn1r238	UTSW	18	3122676	missense	probably damaging	0.99
R9644:Vmn1r238	UTSW	18	3122635	missense	probably benign	0.10
R9725:Vmn1r238	UTSW	18	3122577	missense	probably benign	0.00
Z1177:Vmn1r238	UTSW	18	3122505	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TGGAAACAACTCACTAGGCACA -3'
(R):5'- ATGCTTTATTTATGCTTACTTCACCA -3'

Sequencing Primer
(F):5'- GCACATAGCATAAAGAGACACC -3'
(R):5'- CAAGTTCAGGGATTTTGGAC -3'

Posted On

2015-02-05