Incidental Mutation 'R3024:Arhgef37'
ID 265786
Institutional Source Beutler Lab
Gene Symbol Arhgef37
Ensembl Gene ENSMUSG00000045094
Gene Name Rho guanine nucleotide exchange factor 37
Synonyms 4933429F08Rik
MMRRC Submission 040540-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.149) question?
Stock # R3024 (G1)
Quality Score 225
Status Not validated
Chromosome 18
Chromosomal Location 61624728-61669665 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 61634959 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 461 (E461G)
Ref Sequence ENSEMBL: ENSMUSP00000130560 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171629]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000171629
AA Change: E461G

PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000130560
Gene: ENSMUSG00000045094
AA Change: E461G

DomainStartEndE-ValueType
RhoGEF 34 212 2.62e-35 SMART
Pfam:BAR 311 444 5.6e-10 PFAM
SH3 509 568 8.06e-1 SMART
SH3 606 665 2.56e-14 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bfsp1 A T 2: 143,687,879 (GRCm39) V182D probably benign Het
Birc6 T C 17: 74,915,214 (GRCm39) S1635P possibly damaging Het
Chil6 T C 3: 106,296,086 (GRCm39) D383G probably damaging Het
Itpr2 G A 6: 146,081,808 (GRCm39) A175V probably benign Het
Kcnh7 G T 2: 62,595,007 (GRCm39) R688S probably damaging Het
Krt6a A T 15: 101,599,724 (GRCm39) C463S probably benign Het
Ksr2 T A 5: 117,693,125 (GRCm39) I191N possibly damaging Het
Lyst T C 13: 13,833,272 (GRCm39) V1698A probably benign Het
Or12d13 A T 17: 37,647,918 (GRCm39) D68E probably damaging Het
Or4c127 A T 2: 89,833,584 (GRCm39) N278I probably damaging Het
Pappa2 C T 1: 158,763,795 (GRCm39) R572Q probably benign Het
Pes1 CGGAGGAGGAGGAGGAGGAGGAGG CGGAGGAGGAGGAGGAGGAGG 11: 3,927,719 (GRCm39) probably benign Het
Phf20 A G 2: 156,129,787 (GRCm39) H453R probably damaging Het
Prex1 G T 2: 166,430,956 (GRCm39) H615Q probably benign Het
Slc25a54 T A 3: 108,987,982 (GRCm39) I41N probably damaging Het
Slc35f5 A G 1: 125,496,335 (GRCm39) S157G probably benign Het
Sstr3 G A 15: 78,424,187 (GRCm39) R187W probably damaging Het
Trim41 T C 11: 48,698,985 (GRCm39) K420E possibly damaging Het
Tsnaxip1 A G 8: 106,568,375 (GRCm39) Y353C probably damaging Het
Vmn1r238 T C 18: 3,123,305 (GRCm39) I36M probably benign Het
Xylt1 T A 7: 117,147,883 (GRCm39) V149D probably damaging Het
Zfpm2 G A 15: 40,966,355 (GRCm39) E815K probably benign Het
Other mutations in Arhgef37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00485:Arhgef37 APN 18 61,656,942 (GRCm39) missense probably damaging 1.00
IGL00801:Arhgef37 APN 18 61,632,905 (GRCm39) missense probably damaging 1.00
IGL01146:Arhgef37 APN 18 61,651,081 (GRCm39) missense possibly damaging 0.93
IGL02052:Arhgef37 APN 18 61,632,839 (GRCm39) missense probably damaging 1.00
IGL02489:Arhgef37 APN 18 61,639,540 (GRCm39) missense possibly damaging 0.91
IGL03236:Arhgef37 APN 18 61,656,897 (GRCm39) missense probably damaging 1.00
R0715:Arhgef37 UTSW 18 61,641,860 (GRCm39) missense probably damaging 0.98
R0746:Arhgef37 UTSW 18 61,651,064 (GRCm39) critical splice donor site probably null
R1843:Arhgef37 UTSW 18 61,651,121 (GRCm39) missense probably damaging 0.99
R1934:Arhgef37 UTSW 18 61,657,014 (GRCm39) missense probably benign 0.00
R1980:Arhgef37 UTSW 18 61,641,767 (GRCm39) missense probably damaging 0.98
R2012:Arhgef37 UTSW 18 61,637,427 (GRCm39) missense possibly damaging 0.56
R2237:Arhgef37 UTSW 18 61,637,477 (GRCm39) missense probably damaging 1.00
R4864:Arhgef37 UTSW 18 61,627,996 (GRCm39) missense probably benign
R4876:Arhgef37 UTSW 18 61,631,310 (GRCm39) nonsense probably null
R5024:Arhgef37 UTSW 18 61,639,511 (GRCm39) missense probably damaging 0.99
R5050:Arhgef37 UTSW 18 61,637,402 (GRCm39) missense probably benign 0.43
R5512:Arhgef37 UTSW 18 61,632,845 (GRCm39) nonsense probably null
R5611:Arhgef37 UTSW 18 61,640,334 (GRCm39) missense probably benign 0.03
R6051:Arhgef37 UTSW 18 61,640,345 (GRCm39) missense probably damaging 0.97
R6488:Arhgef37 UTSW 18 61,651,123 (GRCm39) missense probably benign 0.43
R6612:Arhgef37 UTSW 18 61,627,952 (GRCm39) missense probably benign
R7117:Arhgef37 UTSW 18 61,637,481 (GRCm39) missense probably benign 0.00
R7351:Arhgef37 UTSW 18 61,631,286 (GRCm39) missense possibly damaging 0.93
R7426:Arhgef37 UTSW 18 61,637,456 (GRCm39) missense probably damaging 1.00
R7571:Arhgef37 UTSW 18 61,637,403 (GRCm39) missense probably damaging 0.97
R7992:Arhgef37 UTSW 18 61,638,827 (GRCm39) missense probably benign 0.03
R8493:Arhgef37 UTSW 18 61,640,277 (GRCm39) missense probably benign 0.03
R8936:Arhgef37 UTSW 18 61,656,948 (GRCm39) missense probably damaging 0.98
R9000:Arhgef37 UTSW 18 61,637,333 (GRCm39) missense possibly damaging 0.81
R9053:Arhgef37 UTSW 18 61,641,760 (GRCm39) missense probably damaging 1.00
R9298:Arhgef37 UTSW 18 61,651,072 (GRCm39) missense probably damaging 0.98
R9490:Arhgef37 UTSW 18 61,641,907 (GRCm39) missense probably damaging 1.00
R9559:Arhgef37 UTSW 18 61,640,267 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- AGGGAAGCTTCAGCACACTG -3'
(R):5'- CTTCCCCTATGGAGAGATGTTTTC -3'

Sequencing Primer
(F):5'- TTGTGCAGGAGAGCGGC -3'
(R):5'- CCCCTATGGAGAGATGTTTTCTTAAC -3'
Posted On 2015-02-05