Incidental Mutation 'R2302:Mup4'
ID266108
Institutional Source Beutler Lab
Gene Symbol Mup4
Ensembl Gene ENSMUSG00000041333
Gene Namemajor urinary protein 4
SynonymsMup-4
MMRRC Submission 040301-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.050) question?
Stock #R2302 (G1)
Quality Score118
Status Not validated
Chromosome4
Chromosomal Location59956804-59960710 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to A at 59960702 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000103145 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075973] [ENSMUST00000107521]
Predicted Effect probably benign
Transcript: ENSMUST00000075973
SMART Domains Protein: ENSMUSP00000075356
Gene: ENSMUSG00000041333

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
Pfam:Lipocalin 32 171 8.6e-38 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000107521
SMART Domains Protein: ENSMUSP00000103145
Gene: ENSMUSG00000078689

DomainStartEndE-ValueType
Pfam:Lipocalin 25 164 1.4e-35 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency 97% (30/31)
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agpat2 A T 2: 26,604,195 W6R possibly damaging Het
Ahrr C A 13: 74,277,661 V72F probably damaging Het
Ank1 G A 8: 23,119,399 C1369Y probably damaging Het
Cdh3 C A 8: 106,545,069 P538Q probably damaging Het
Cnn2 C G 10: 79,991,399 R35G possibly damaging Het
Csmd3 C A 15: 48,314,051 A364S probably benign Het
Dhcr7 A G 7: 143,837,892 T73A probably benign Het
Gbp9 T C 5: 105,094,092 N200D possibly damaging Het
Hyls1 T C 9: 35,564,069 E3G possibly damaging Het
Ifngr1 T C 10: 19,609,645 L464P probably damaging Het
Kdm1b TCATTGTCC TCATTGTCCATTGTCC 13: 47,064,088 probably null Het
Krt1 C T 15: 101,846,187 G543S unknown Het
Lhfpl2 T C 13: 94,174,546 V108A probably benign Het
Lrrc7 C G 3: 158,135,244 G1386R probably damaging Het
Mlc1 A G 15: 88,965,437 V231A possibly damaging Het
Myh8 A T 11: 67,286,239 R406W probably damaging Het
Poldip3 T C 15: 83,129,268 probably benign Het
Pomt1 G A 2: 32,243,659 G216S probably benign Het
Ppil6 T A 10: 41,501,799 C169S probably damaging Het
Prokr2 A G 2: 132,381,184 I146T probably damaging Het
Rab3b T C 4: 108,929,443 V130A probably damaging Het
Reck T A 4: 43,931,015 I672N probably benign Het
Scn1a T C 2: 66,277,745 T1546A probably damaging Het
Sftpd T A 14: 41,172,442 E340V probably damaging Het
Slco5a1 C T 1: 12,879,262 G635S probably damaging Het
Slfn10-ps A T 11: 83,028,930 noncoding transcript Het
Svopl A T 6: 38,041,166 probably benign Het
Tbx5 A G 5: 119,841,859 K157E probably damaging Het
Ttn A T 2: 76,894,352 C6333S probably benign Het
Zfp609 T C 9: 65,794,897 K158E possibly damaging Het
Zscan20 T C 4: 128,588,264 N535S probably damaging Het
Other mutations in Mup4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01550:Mup4 APN 4 59960120 missense probably damaging 1.00
IGL02956:Mup4 APN 4 59959263 missense probably benign 0.08
IGL03017:Mup4 APN 4 59957890 missense probably damaging 0.99
IGL03139:Mup4 APN 4 59958482 splice site probably benign
IGL03282:Mup4 APN 4 59958547 missense possibly damaging 0.56
marine UTSW 4 59960622 unclassified probably benign
R1440:Mup4 UTSW 4 59958076 missense probably damaging 1.00
R1462:Mup4 UTSW 4 59960084 missense possibly damaging 0.91
R1462:Mup4 UTSW 4 59960084 missense possibly damaging 0.91
R1721:Mup4 UTSW 4 59960598 start codon destroyed probably null
R2067:Mup4 UTSW 4 59960622 unclassified probably benign
R2403:Mup4 UTSW 4 59958145 missense probably damaging 0.98
R3431:Mup4 UTSW 4 59959192 splice site probably null
R4487:Mup4 UTSW 4 59960547 missense probably damaging 0.98
R5028:Mup4 UTSW 4 59958124 missense possibly damaging 0.69
R5208:Mup4 UTSW 4 59958119 missense probably damaging 1.00
R5430:Mup4 UTSW 4 59960044 missense probably damaging 0.98
R6255:Mup4 UTSW 4 59957890 missense probably damaging 0.99
R6304:Mup4 UTSW 4 59960084 missense possibly damaging 0.91
R6745:Mup4 UTSW 4 59960091 missense possibly damaging 0.50
R7326:Mup4 UTSW 4 59960046 missense possibly damaging 0.95
R7606:Mup4 UTSW 4 59958568 missense probably damaging 1.00
X0026:Mup4 UTSW 4 59960559 missense possibly damaging 0.46
Predicted Primers
Posted On2015-02-05