Incidental Mutation 'R2924:Mrgpra1'
ID266201
Institutional Source Beutler Lab
Gene Symbol Mrgpra1
Ensembl Gene ENSMUSG00000050650
Gene NameMAS-related GPR, member A1
SynonymsMrgA1
MMRRC Submission 040509-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.056) question?
Stock #R2924 (G1)
Quality Score225
Status Not validated
Chromosome7
Chromosomal Location47334875-47354240 bp(-) (GRCm38)
Type of Mutationunclassified (5 bp from exon)
DNA Base Change (assembly) G to A at 47334870 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000129978 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098438]
Predicted Effect probably null
Transcript: ENSMUST00000098438
SMART Domains Protein: ENSMUSP00000129978
Gene: ENSMUSG00000050650

DomainStartEndE-ValueType
low complexity region 14 27 N/A INTRINSIC
low complexity region 36 49 N/A INTRINSIC
Pfam:7tm_1 57 225 2.1e-8 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bcl9 A G 3: 97,209,753 S542P probably benign Het
Cass4 A G 2: 172,426,672 R225G possibly damaging Het
Ddx50 A T 10: 62,627,594 V440E probably damaging Het
Dmrtc2 G A 7: 24,872,516 C12Y probably damaging Het
Dock6 A T 9: 21,809,630 I1693N probably damaging Het
Fuom T C 7: 140,099,949 T110A probably benign Het
Gli2 C T 1: 118,836,359 R1354H probably benign Het
Gm5478 A T 15: 101,643,794 probably null Het
Hsp90aa1 T A 12: 110,695,680 M1L possibly damaging Het
Hsp90aa1 C A 12: 110,695,681 probably null Het
Il2rb T C 15: 78,491,849 M1V probably null Het
Ints6l A G X: 56,504,836 E483G probably benign Het
Kalrn C T 16: 33,989,810 D2525N possibly damaging Het
Kcnd3 C T 3: 105,658,766 A421V probably damaging Het
Man2b2 A G 5: 36,824,102 F224L probably benign Het
Mtbp G A 15: 55,619,814 R429Q probably benign Het
Ncapg2 C A 12: 116,438,729 T727K probably benign Het
Nsf C T 11: 103,930,752 E26K possibly damaging Het
Nup214 A G 2: 31,998,003 K15E probably damaging Het
Olfr394 A G 11: 73,887,511 I287T probably damaging Het
Oxr1 T C 15: 41,825,957 Y526H probably benign Het
Plec A G 15: 76,178,252 F2563S probably damaging Het
Prex2 A G 1: 11,098,487 T236A probably damaging Het
Rbbp5 G C 1: 132,492,663 probably null Het
Slc24a2 A G 4: 87,011,724 S512P probably benign Het
Srd5a1 A G 13: 69,586,715 S191P probably damaging Het
Syt3 T A 7: 44,395,798 V518E probably damaging Het
Tmem132e T C 11: 82,444,323 S652P probably damaging Het
Uba6 A T 5: 86,159,271 V102D probably damaging Het
Unc13a A G 8: 71,644,952 V1158A possibly damaging Het
Upk3a A G 15: 85,018,149 Y59C probably benign Het
Zc3hav1 T C 6: 38,354,110 Y38C probably damaging Het
Zfp119a C A 17: 55,868,343 D51Y possibly damaging Het
Other mutations in Mrgpra1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00903:Mrgpra1 APN 7 47335578 missense probably benign 0.00
IGL01317:Mrgpra1 APN 7 47335624 missense probably benign 0.00
IGL01718:Mrgpra1 APN 7 47335927 splice site probably null
IGL02252:Mrgpra1 APN 7 47335164 missense probably benign 0.00
IGL03301:Mrgpra1 APN 7 47335416 missense probably benign
R0012:Mrgpra1 UTSW 7 47335470 missense probably damaging 0.98
R1019:Mrgpra1 UTSW 7 47335085 missense probably benign 0.00
R2224:Mrgpra1 UTSW 7 47335106 missense possibly damaging 0.50
R2520:Mrgpra1 UTSW 7 47335272 missense possibly damaging 0.75
R3038:Mrgpra1 UTSW 7 47334996 nonsense probably null
R3900:Mrgpra1 UTSW 7 47335527 missense possibly damaging 0.76
R4692:Mrgpra1 UTSW 7 47335698 missense probably damaging 1.00
R4783:Mrgpra1 UTSW 7 47335470 missense probably damaging 0.98
R4784:Mrgpra1 UTSW 7 47335470 missense probably damaging 0.98
R4785:Mrgpra1 UTSW 7 47335470 missense probably damaging 0.98
R4981:Mrgpra1 UTSW 7 47335211 missense probably damaging 1.00
R5031:Mrgpra1 UTSW 7 47335237 nonsense probably null
R6760:Mrgpra1 UTSW 7 47335041 missense probably benign 0.03
R7305:Mrgpra1 UTSW 7 47335455 missense probably benign 0.38
R7348:Mrgpra1 UTSW 7 47335409 missense probably benign 0.09
R7837:Mrgpra1 UTSW 7 47335328 missense possibly damaging 0.68
R8158:Mrgpra1 UTSW 7 47335456 nonsense probably null
X0012:Mrgpra1 UTSW 7 47335875 missense probably benign
Predicted Primers
Posted On2015-02-05